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. 1978 Jun;75(6):2603–2605. doi: 10.1073/pnas.75.6.2603

Identification of 5,8-oxyretinoic acid isolated from small intestine of vitamin A-deficient rats dosed with retinoic acid.

J L Napoli, A M McCormick, H K Schnoes, H F DeLuca
PMCID: PMC392610  PMID: 275830

Abstract

A retinoid was isolated by a multistep procedure from the small intestines of vitamin A-deficient rats given a single dose of retinoic acid. The compound, designated 8II, was pure, as demonstrated by four high-pressure liquid chromatographic procedures. It was positively identified as 5,8-oxyretinoic acid by ultraviolet spectrophotometry, mass spectrometry, and spectral and chromatographic comparison to known compounds. It is probable that 5,8-oxyretinoic acid was produced from 5,6-epoxyretinoic acid under the acidic conditions used in the isolation. It is highly probable, therefore, that the natural product is 5,6-epoxyretinoic acid.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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