Table 4.

Commonly mutated genes in pancreatic cancer.

	Gene	This Study $	ICGC (99) $	Jones (24) $	Total	Common Site	Case	Tissue	Chr.	Position	Amino acid	Impact	Allele 1	Allele 2
T	SMAD4	2	16	8	26	n	37	T	18	48591919	R361H	D	G 16	A 12
						n	10	T	18	48603054	A452fs	D	C 6	CT 8
	DNAH8	1	1	1	3	n	10	T	6	38723768	I476M	D	A 67	G 26
	MYO1E	1	2	0	3	n	37	T	15	59564510	I48V	D	T 60	C 19
	NTRK3	1	1	1	3	n	6	T	15	88476311	C599*	D	G 47	T 16
T, PxT	TP53	7	33	18	58	y	Table 1
	ATM	2	5	0	7	n	10	T	11	108214082	C2801Y	D	G33	A 14
						n	41	PxT	11	108142067	S1004N	T	G 90	A 44
	NEB	2	5	1	8	n	41	PxT	2	152474902	E3400Q	D	C 143	G 107
						n	37	T	2	152421598	H4431R	T	T 103	C 32
PxT	SLITRK3	1	1	1	3	n	6	PxT	3	164906758	G621*	D	C 20	A 10
	ATP10A	1	1	2	4	n	2	PxT	15	25959351	T605M	D	G 18	A 16
	CDH4	1	2	0	3	n	6	PxT	20	60499411	P476S	D	C 24	T 8
	CSMD1	1	5	1	7	n	2	PxT	8	4494898	D90N	D	C 46	T 26
	DPP6	1	1	3	5	n	8	PxT	7	154593134	R393*	D	C 31	T 32
	FNIP1	1	1	1	3	n	6	PxT	5	131008104	L650S	D	A 39	G 13
	HMCN1	1	4	0	5	n	41	PxT	1	186063449	C3413F	D	G26	T 56
	KRAS	9	94	24	118	y	Table 1
	LRFN5	1	0	2	3	n	2	PxT	14	42355997	R57W	D	C 26	T 18
	MLL3	1	6	4	11	n	2	PxT	7	151860002	F3553fs	D	T 11	TA 18
	MUC16	4	5	2	11	n	12	PxT	19	8993006	Splice Site	N	C 21	A 28
						n	12	P	19	9066456	P6997R	N	G 110	C 110
						n	6	PxT	19	9063763	P7895T	N	G 34	T 13
						n	2	PxT	19	8999458	Q13573K	D	G 62	T 10
						n	41	PxT	19	9048237	S11132G	N	T 164	C 86
	ODZ4	1	1	1	3	n	41	PxT	11	78381167	G2075R	D	C 158	G 70
	PKHD1L1	1	2	0	3	n	2	PxT	8	110454274	N1415H	D	A 37	C 8
	RYR1	1	1	1	3	n	41	PxT	19	38991484	M2490V	T	A 18	G 4
	RYR2	2	2	2	6	n	6	PxT	1	237870277	D3203E	T	T 6	A 9
						n	37	P	1	237604778	R389C	D	C 161	T45
	RYR3	1	4	0	5	n	10	T	15	34145258	N4542K	T	T 98	A 34
	SCN2A	1	1	1	3	n	41	PxT	2	166187962	D758H	D	G 92	C 54
	SPATA17	1	1	1	3	n	41	PxT	1	217975170	P328L	D	C 35	T 33
	SYCE1	1	3	1	5	n	2	PxT	10	135368531	P341S	D	G48	A 24
	USP34	1	2	0	3	n	6	PxT	2	61622085	K219T	D	T 12	G 9
PxT, P	APOB	2	1	1	4	n	2	P	2	21225615	V4227L	T	C 24	A 14
						n	6	PxT	2	21245863	N886H	D	T 22	G 19
	FN1	2	1	1	4	n	4	PxT	2	216259428	R1207G	D	T 36	C 19
						n	2	P	2	216271900	E888V	D	T70	A 25
	OBSCN	2	2	1	5	n	37	P	1	228433195	C1188F	D	G 104	T 20
						n	4	PxT	1	228505380	R4593C	D	C 42	T 42
P	CDH23	1	2	0	3	n	37	P	10	73553299	P2205L	D	C 77	T 32
	GPR133	1	1	2	4	n	8	P	12	131456051	K79M	D	A 50	T 35
	LAMA1	1	1	1	3	n	12	P	18	7042183	K407fs	D	CAG 14	C 7
	NAV3	1	1	1	3	n	41	P	12	78594300	V2233L	D	G 97	T 35
	NBAS	1	3	0	4	n	6	P	2	15613348	L575M	D	A 21	T 10
	PCDHGA1	1	1	1	3	n	2	P	5	140711164	E305*	D	G 15	T 32

Columns: Tissue, Amino Acid, Chr. (Chromosome), Position (nucleotide), Impact (SIFT/Polyphen), Allele 1 and Allele 2 (nucleotide and read depth) as presented as in Table 3; “Genes” refers to genes commonly mutated in This Study, (ICGC) Biankin et al. (24) and Jones et al. (11).

^$The number of cases mutated in each study is shown;. “Common site” refers to identical mutations in the studies; “Case” refers to the specific case in This Study with a mutation in the specific gene.