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. 1978 Jun;75(6):2888–2892. doi: 10.1073/pnas.75.6.2888

Nutritional inhibition of genetically determined renal disease and autoimmunity with prolongation of life in kdkd mice.

G Fernandes, E J Yunis, M Miranda, J Smith, R A Good
PMCID: PMC392670  PMID: 275859

Abstract

Striking inhibition of development of renal disease and prolongation of lifespan have been achieved in kdkd mice by restricting their daily food intake. Restricting protein intake alone did not prolong life nor did it inhibit development of kidney disease. The kdkd nephronophthisis, although very different histologically from the renal disease of B/W mice, may also have immunological components. Like the immunologically based renal disease of B/W mice, renal disease in kdkd mice is decreased or eliminated histologically by dietary restriction, which inhibits development of autoimmunity directed toward the erythrocytes of these mice. Further analysis will be needed to elucidate the cause of progressive renal disease in both the kdkd and B/W models and to permit understanding of the profound influence of restriction of food intake on development and progression of these very different renal diseases.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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