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. 1978 Jul;75(7):3432–3436. doi: 10.1073/pnas.75.7.3432

Interspecies transmission of Creutzfeldt-Jakob disease to Syrian hamsters with reference to clinical syndromes and strains of agent.

E E Manuelidis, E J Gorgacz, L Manuelidis
PMCID: PMC392791  PMID: 356055

Abstract

Experimental Creutzfeldt-Jakob disease was serially transmitted from guinea pigs to Syrian hamsters with 100% incidence, morbidity, and mortality. All animals developed a subacute spongiform virus encephalopathy with neuronal destruction and concomitant astrocytic changes. In the first passage three different clinical syndromes were recorded, each with widely variant incubation times; these results suggested there may be different strains of the Creutzfeldt-Jakob agent, some of which may be partially separated when the agent is passaged from one species to another. Accumulations of neurofilaments in neuronal perikarya and processes and increased lipofuscin were suggestive of changes seen in senility and aging.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALEMA G., BIGNAMI A. [Subacute degenerative presenile polioencephalopathy with akinetic stupor and decorticate rigidity with myoclonus ("myoclonic" variety of the Jakob-Creutzfeld disease)]. Riv Sper Freniatr Med Leg Alien Ment. 1959 Dec 31;83(4):1485–1623. [PubMed] [Google Scholar]
  2. Bobowick A. R., Brody J. A., Matthews M. R., Roos R., Gajdusek D. C. Creutzfeldt-Jakob disease: a case-control study. Am J Epidemiol. 1973 Nov;98(5):381–394. doi: 10.1093/oxfordjournals.aje.a121567. [DOI] [PubMed] [Google Scholar]
  3. Dickinson A. G. Host-pathogen interactions in scrapie. Genetics. 1975 Jun;79 (Suppl):387–395. [PubMed] [Google Scholar]
  4. Dickinson A. G., Meikle V. M. Host-genotype and agent effects in scrapie incubation: change in allelic interaction with different strains of agent. Mol Gen Genet. 1971;112(1):73–79. doi: 10.1007/BF00266934. [DOI] [PubMed] [Google Scholar]
  5. Fraser H., Bruce M. Argyrophilic plaques in mice inoculated with scrapie from particular sources. Lancet. 1973 Mar 17;1(7803):617–618. doi: 10.1016/s0140-6736(73)90775-7. [DOI] [PubMed] [Google Scholar]
  6. Fraser H., Dickinson A. G. Scrapie in mice. Agent-strain differences in the distribution and intensity of grey matter vacuolation. J Comp Pathol. 1973 Jan;83(1):29–40. doi: 10.1016/0021-9975(73)90024-8. [DOI] [PubMed] [Google Scholar]
  7. Gibbs C. J., Jr, Gajdusek D. C. Isolation and characterization of the subacute spongiform virus encephalopathies of man: kuru and Creutzfeldt-Jakob disease. J Clin Pathol Suppl (R Coll Pathol) 1972;6:84–96. [PMC free article] [PubMed] [Google Scholar]
  8. Kimberlin R. H., Walker C. Characteristics of a short incubation model of scrapie in the golden hamster. J Gen Virol. 1977 Feb;34(2):295–304. doi: 10.1099/0022-1317-34-2-295. [DOI] [PubMed] [Google Scholar]
  9. Manuelidis E. E., Angelo J. N., Gorgacz E. J., Manuelidis L. Transmission of Creutzfeldt-Jakob disease to Syrian hamster. Lancet. 1977 Feb 26;1(8009):479–479. doi: 10.1016/s0140-6736(77)91959-6. [DOI] [PubMed] [Google Scholar]
  10. Manuelidis E. E., Gorgacz E. J., Manuelidis L. Transmission of Creutzfeldt-Jakob disease with scrapie-like syndromes to mice. Nature. 1978 Feb 23;271(5647):778–779. doi: 10.1038/271778a0. [DOI] [PubMed] [Google Scholar]
  11. Manuelidis E. E., Kim J., Angelo J. N., Manuelidis L. Serial propagation of Creutzfeldt-Jakob disease in guinea pigs. Proc Natl Acad Sci U S A. 1976 Jan;73(1):223–227. doi: 10.1073/pnas.73.1.223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Manuelidis E. E. Transmission of Creutzfeldt-Jakob disease from man to the guinea pig. Science. 1975 Nov 7;190(4214):571–572. [PubMed] [Google Scholar]
  13. Marsh R. F., Kimberlin R. H. Comparison of scrapie and transmissible mink encephalopathy in hamsters. II. Clinical signs, pathology, and pathogenesis. J Infect Dis. 1975 Feb;131(2):104–110. doi: 10.1093/infdis/131.2.104. [DOI] [PubMed] [Google Scholar]
  14. Nevin S. On some aspects of cerebral degeneration in later life. Proc R Soc Med. 1967 Jun;60(6):517–526. [PMC free article] [PubMed] [Google Scholar]
  15. PATTISON I. H., MILLSON G. C. Scrapie produced experimentally in goats with special reference to the clinical syndrome. J Comp Pathol. 1961 Apr;71:101–109. doi: 10.1016/s0368-1742(61)80013-1. [DOI] [PubMed] [Google Scholar]
  16. Pattison I. H., Jones K. M. Modification of a strain of mouse-adapted scrapie by passage through rats. Res Vet Sci. 1968 Sep;9(5):408–410. [PubMed] [Google Scholar]
  17. Pattison I. H. The relative susceptibility of sheep, goats and mice to two types of the goat scrapie agent. Res Vet Sci. 1966 Apr;7(2):207–212. [PubMed] [Google Scholar]
  18. ZLOTNIK I., RENNIE J. C. EXPERIMENTAL TRANSMISSION OF MOUSE PASSAGED SCRAPIE TO GOATS, SHEEP, RATS AND HAMSTERS. J Comp Pathol. 1965 Apr;75:147–157. doi: 10.1016/0021-9975(65)90005-8. [DOI] [PubMed] [Google Scholar]

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