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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Gastroenterology. 2013 Jan 24;144(5):1076–1085.e2. doi: 10.1053/j.gastro.2013.01.041

Figure 4. (A) Ductular metaplasia in CP groups.

Figure 4

Representative cytokeratin-19 stained sections (100×) from controls and CP groups showing increase in ductular/tubular complexes. These structures were counted in high power (100×) fields (B). Tubular complexes (per field) increased to 30±1, 34±1, 32±1 in WT, T−/−, CB−/− CP groups from 3±0.2 in controls (P<.0001 for each CP group vs controls, N=10/group). (C) Aquaporin-1 (AQP1) overexpression in CP: Dysfunction of ducts in CP is believed to cause compensatory overexpression of water channels Aquaporin-1 (see text). Comparable overexpression of AQP1 was seen in WT, T−/− and CB−/− groups with CP as compared to controls. Representative AQP-1 stained sections (200×) are shown (N=10/group).