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. 1978 Aug;75(8):3776–3780. doi: 10.1073/pnas.75.8.3776

Post-transcriptional suppression of globin gene expression in cells transformed by avian erythroblastosis virus.

A Therwath, K Scherrer
PMCID: PMC392869  PMID: 211506

Abstract

Cells transformed by avian erythroblastosis virus were grown in vitro for up to 5 months. After a few days in culture, synthesis of hemoglobin was undetectable and could not be induced by dimethyl sulfoxide. As shown by globin cDNA hybridization to nuclear and cytoplasmic RNA carried to Crot values of 10(5) moles of nucleotide per liter X sec, globin genes in these cells are transcribed into pre-mRNA, but no trace of globin mRNA appears in the cytoplasm. The implications of this observation for schemes of post-transcriptional regulations and viral transformation are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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