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. 1978 Aug;75(8):3962–3964. doi: 10.1073/pnas.75.8.3962

X-ray sensitivity of diploid fibroblasts from patients with hereditary or sporadic retinoblastoma.

R R Weichselbaum, J Nove, J B Little
PMCID: PMC392909  PMID: 279012

Abstract

Fibroblasts derived from patients with hereditary retinoblastoma appear to be more sensitive to the lethal effects of x-rays than do fibroblasts from patients with sporadic retinoblastoma or normal controls. A defect in DNA repair is postulated to account for the high incidence of second tumors in these patients. Retinoblastoma appears to be an interesting model for the study of genetic susceptibility to the development of spontaneous or radiation-induced tumors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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