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. 1978 Nov;75(11):5250–5254. doi: 10.1073/pnas.75.11.5250

Energetics of enzyme catalysis.

A Warshel
PMCID: PMC392938  PMID: 281676

Abstract

Quantitative studies of the energetics of enzymatic reactions and the corresponding reactions in aqueous solutions indicate that charge stabilization is the most important energy contribution in enzyme catalysis. Low electrostatic stabilization in aqueous solutions is shown to be consistent with surprisingly large electrostatic stabilization effects in active sites of enzymes. This is established quantitatively by comparing the relative stabilization of the transition states of the reaction of lysozyme and the corresponding reaction is aqueous solution.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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