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. 1978 Nov;75(11):5353–5357. doi: 10.1073/pnas.75.11.5353

Quantitative determination of the lateral diffusion coefficients of the hormone-receptor complexes of insulin and epidermal growth factor on the plasma membrane of cultured fibroblasts.

J Schlessinger, Y Shechter, P Cuatrecasas, M C Willingham, I Pastan
PMCID: PMC392961  PMID: 214784

Abstract

Fluorescent derivatives of insulin and epidermal growth factor bound to 3T3 mouse fibroblasts are mobile on the cell surface, with similar diffusion coefficients, D approximately (3--5) x 10(-10) cm2/sec at 23 degrees C. Increasing the temperature to 37 degrees C results in rapid receptor immobilization. The immobilization is attributed to aggregation of hormone-receptor complexes, their internalization, or a combination of both processes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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