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. 1978 Nov;75(11):5618–5622. doi: 10.1073/pnas.75.11.5618

Model for evolution of Y chromosomes and dosage compensation.

B Charlesworth
PMCID: PMC393018  PMID: 281711

Abstract

Some difficulties with the classical model for the evolution of a genetically invert Y chromosome are discussed. An alternative model is proposed, which is based on the principle of Mullers ratchet; this involves the accumulation of chromosomes bearing deleterious mutant genes in a finite population in the absence of crossing-over. This process would result in the gradual increase, with time, in the number of mutant loci carried in an average Y chromosome, although the frequency of individual deleterious alleles at most loci remains low. It is shown that this creates a selection pressure for differentially increasing the activity of the X chromosome in heterogametic individuals at the expense of that of the Y, leading eventually to a genetically inert Y chromosome and to the evolution of dosage compensation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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