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. 1978 Nov;75(11):5623–5626. doi: 10.1073/pnas.75.11.5623

Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse.

C M Wilson, E G Erdös, J D Wilson, B A Taylor
PMCID: PMC393019  PMID: 281712

Abstract

Renin activity (EC 3.4.99.19) was measured in submaxillary gland extracts from four sets of recombinant inbred mouse strains. Recombination between Rnr, a gene that mediates the susceptibility of submaxillary gland renin to induction by androgen, and Dip-1, a chromosome 1 marker, was found in only 1 of 51 recombinant inbred strains, indicating that the two genes are closely linked on chromosome 1. Renin activity in androgen-treated female mice of all recombinant inbred strains resembled that of one or the other progenitor strains, as expected if a single gene is responsible. Documentation that a single gene can have major effects on renin in the submaxillary gland of the mouse implies that single gene differences might explain known variations in renin in other species.

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Selected References

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