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. 1978 Nov;75(11):5702–5705. doi: 10.1073/pnas.75.11.5702

Reversal of renovascular hypertension by antibodies specific for angiotensin-converting enzyme.

R A Markle, E H Sonnenblick, J M Conroy, R L Soffer
PMCID: PMC393036  PMID: 214795

Abstract

Goat antibodies developed against pure rabbit pulmonary angiotensin-converting enzyme (peptidyl dipeptidase, EC 3.4.15.1) were administered intravenously to rats with two-kidney Goldblatt hypertension and to normotensive animals. In the hypertensive model these antibodies were associated with a sustained, immune-dependent decrease of blood pressure to normal values. A smaller, but also immune-specific, reduction of blood pressure was observed in the normotensive group. The data suggest that heterologous antibody directed against angiotensin-converting enzyme may provide a biologically specific probe for examining the contribution of the renin-angiotensin system to normal and pathologic circulatory states.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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