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. 1978 Dec;75(12):5893–5897. doi: 10.1073/pnas.75.12.5893

Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA.

P J Farrell, G C Sen, M F Dubois, L Ratner, E Slattery, P Lengyel
PMCID: PMC393082  PMID: 282611

Abstract

Double-stranded RNA inhibits protein synthesis in at least two ways. It activates a protein kinase that blocks peptide chain initiation by phosphorylating the peptide chain initiation factor eIF-2 and also activates an endonuclease that inactivates different mRNAs at different rates. The protein kinase and the endonuclease have been partially purified from interferon-treated Ehrlich ascites tumor cells. The 2',5'-oligoadenylates [pppA(2'p5'A)n], found found earlier to be mediators in the activation of the endonuclease by double-stranded RNA, are not mediators in the activation of the protein kinase by double-stranded RNA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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