Figure 3.

Increased islet size, β-cell nuclear size, and glucagon area in insulin-resistant subjects. A: Insulin, glucagon, and somatostatin areas evaluated as fraction of total pancreatic section area. B: Mean islet size in insulin-sensitive and insulin-resistant subjects. C: Glucose uptake vs. islet size. Correlation between insulin sensitivity index and islet size is shown in all of the subjects. D: Mean β-cell area in insulin-sensitive and insulin-resistant subjects. E: Mean β-cell nuclear area in insulin-sensitive and insulin-resistant subjects. F: Islet density in insulin-sensitive and insulin-resistant subjects. *P ≤ 0.05, **P ≤ 0.001.