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. 1978 Dec;75(12):6225–6229. doi: 10.1073/pnas.75.12.6225

Linear arrays of intramembranous particles in pulmonary tubular myelin.

E Y Chi, D Lagunoff
PMCID: PMC393152  PMID: 282638

Abstract

Freeze-fracture preparations of tubular myelin in edematous rat lungs reveal the presence of linear arrays of intramembranous particles. The lines of particles are approximately 50 nm apart and appear to correspond to the intersections of sheets of bilayer membranes. Particles are not seen in lamellar bodies but become evident first in membranes transitional between lamellar bodies and tubular myelin. It is proposed that the particles represent a hydrophobic protein that plays a significant role in the organization of tubular myelin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Balis J. U., Shelley S. A., McCue M. J., Rappaport E. S. Mechanisms of damage to the lung surfactant system. Ultrastructure and quantitation of normal and in vitro inactivated lung surfactant. Exp Mol Pathol. 1971 Apr;14(2):243–262. doi: 10.1016/0014-4800(71)90069-4. [DOI] [PubMed] [Google Scholar]
  2. Belton J. C., Branton D., Thomas H. V., Mueller P. K. Freeze-etch observations of rat lung. Anat Rec. 1971 Aug;170(4):471–483. doi: 10.1002/ar.1091700408. [DOI] [PubMed] [Google Scholar]
  3. Bhattacharyya S. N., Passero M. A., DiAugustine R. P., Lynn W. S. Isolation and characterization of two hydroxyproline-containing glycoproteins from normal animal lung lavage and lamellar bodies. J Clin Invest. 1975 May;55(5):914–920. doi: 10.1172/JCI108020. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bhattacharyya S. N., Rose M. C., Lynn M. G., MacLeod C., Alberts M., Lynn W. S. Isolation and characterization of a unique glycoprotein from lavage of chicken lungs and lamellar organelles. Am Rev Respir Dis. 1976 Nov;114(5):843–850. doi: 10.1164/arrd.1976.114.5.843. [DOI] [PubMed] [Google Scholar]
  5. Chi E. Y., Lagunoff D., Koehler J. K. Abnormally large lamellar bodies in type II pneumocytes in Chediak-Higashi syndrome in beige mice. Lab Invest. 1976 Feb;34(2):166–173. [PubMed] [Google Scholar]
  6. Finley T. N., Pratt S. A., Ladman A. J., Brewer L., McKay M. B. Morphological and lipid analysis of the alveolar lining material in dog lung. J Lipid Res. 1968 May;9(3):357–365. [PubMed] [Google Scholar]
  7. Gil J., Reiss O. K. Isolation and characterization of lamellar bodies and tubular myelin from rat lung homogenates. J Cell Biol. 1973 Jul;58(1):152–171. doi: 10.1083/jcb.58.1.152. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Grant C. W., McConnell H. M. Glycophorin in lipid bilayers. Proc Natl Acad Sci U S A. 1974 Dec;71(12):4653–4657. doi: 10.1073/pnas.71.12.4653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hong K., Hubbell W. L. Preparation and properties of phospholipid bilayers containing rhodopsin. Proc Natl Acad Sci U S A. 1972 Sep;69(9):2617–2621. doi: 10.1073/pnas.69.9.2617. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kikkawa Y. Morphology of alveolar lining layer. Anat Rec. 1970 Aug;167(4):389–400. doi: 10.1002/ar.1091670403. [DOI] [PubMed] [Google Scholar]
  11. King R. J., Clements J. A. Surface active materials from dog lung. II. Composition and physiological correlations. Am J Physiol. 1972 Sep;223(3):715–726. doi: 10.1152/ajplegacy.1972.223.3.715. [DOI] [PubMed] [Google Scholar]
  12. King R. J. The surfactant system of the lung. Fed Proc. 1974 Nov;33(11):2238–2247. [PubMed] [Google Scholar]
  13. Kistler G. S., Caldwell P. R., Weibel E. R. Development of fine structural damage to alveolar and capillary lining cells in oxygen-poisoned rat lungs. J Cell Biol. 1967 Mar;32(3):605–628. doi: 10.1083/jcb.32.3.605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Kuhn C., 3rd A comparison of freeze-substitution with other methods for preservation of the pulmonary alveolar lining layer. Am J Anat. 1972 Apr;133(4):495–507. doi: 10.1002/aja.1001330410. [DOI] [PubMed] [Google Scholar]
  15. Leeson T. S., Leeson C. R. Osmiophilic lamellated bodies and associated material in lung alveolar spaces. J Cell Biol. 1966 Mar;28(3):577–581. doi: 10.1083/jcb.28.3.577. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. MacLennan D. H., Seeman P., Iles G. H., Yip C. C. Membrane formation by the adenosine triphosphatase of sarcoplasmic reticulum. J Biol Chem. 1971 Apr 25;246(8):2702–2710. [PubMed] [Google Scholar]
  17. Marchesi V. T., Furthmayr H., Tomita M. The red cell membrane. Annu Rev Biochem. 1976;45:667–698. doi: 10.1146/annurev.bi.45.070176.003315. [DOI] [PubMed] [Google Scholar]
  18. Passero M. A., Tye R. W., Kilburn K. H., Lynn W. S. Isolation and characterization of two glycoproteins from patients with alveolar proteinosis. Proc Natl Acad Sci U S A. 1973 Apr;70(4):973–976. doi: 10.1073/pnas.70.4.973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Sanderson R. J., Paul G. W., Vatter A. E., Filley G. F. Morphological and physical basis for lung surfactant action. Respir Physiol. 1976 Sep;27(3):379–392. doi: 10.1016/0034-5687(76)90066-9. [DOI] [PubMed] [Google Scholar]
  20. Steck T. L. The organization of proteins in the human red blood cell membrane. A review. J Cell Biol. 1974 Jul;62(1):1–19. doi: 10.1083/jcb.62.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Stratton C. J. The three-dimensional aspect of the mammalian lung surfactant myelin figure. Tissue Cell. 1977;9(2):285–300. doi: 10.1016/0040-8166(77)90022-2. [DOI] [PubMed] [Google Scholar]
  22. Sun C. N. Lattice structures and osmiophilic bodies in the developing respiratory tissue of rats. J Ultrastruct Res. 1966 Jun;15(3):380–388. doi: 10.1016/s0022-5320(66)80114-4. [DOI] [PubMed] [Google Scholar]
  23. Weibel E. R., Kistler G. S., Töndury G. A stereologic electron microscope study of "tubular myelin figures" in alveolar fluids of rat lungs. Z Zellforsch Mikrosk Anat. 1966;69:418–427. doi: 10.1007/BF00406293. [DOI] [PubMed] [Google Scholar]
  24. Williams M. C. Conversion of lamellar body membranes into tubular myelin in alveoli of fetal rat lungs. J Cell Biol. 1977 Feb;72(2):260–277. doi: 10.1083/jcb.72.2.260. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Williams M. C., Mason R. J. Development of the type II cell in the fetal rat lung. Am Rev Respir Dis. 1977 Jun;115(6 Pt 2):37–47. doi: 10.1164/arrd.1977.115.S.37. [DOI] [PubMed] [Google Scholar]

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