Abstract
alpha-Melanocyte stimulating hormone (alpha-melanotropin) immunofluorescence was observed in rat brain by means of a highly specific and well-characterized antibody. The hormone was contained in arcuate nucleus cell bodies and in varicose fibers. Dense populations of hormone-containing fibers were present in the septum, the nucleus interstitialis stria terminalis, and the medial preoptic, anterior hypothalamic, dorsomedial, and periventricular nuclei. Moderate numbers of fibers were seen in the paraventricular and arcuate nuclei, the amygdala, the region of the tractus diagonalis, the mammillary body, the central gray, the cuneiform nucleus, and the nucleus of the solitary tract. There is an interesting correlation of alpha-melanocyte stimulating hormone fibers with regions of noradrenergic axonal projections and terminal fields.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barnea A., Oliver C., Porter J. C. Subcellular localization of alpha-melanocyte-stimulating hormone in the rat hypothalamus. J Neurochem. 1977 Oct;29(4):619–624. doi: 10.1111/j.1471-4159.1977.tb07777.x. [DOI] [PubMed] [Google Scholar]
- COONS A. H. Fluorescent antibody methods. Gen Cytochem Methods. 1958;1:399–422. [PubMed] [Google Scholar]
- HARRIS J. I., LERNER A. B. Amino-acid sequence of the alpha-melanocyte-stimulating hormone. Nature. 1957 Jun 29;179(4574):1346–1347. doi: 10.1038/1791346a0. [DOI] [PubMed] [Google Scholar]
- Hökfelt T., Elde R., Fuxe K., Johansson O., Ljungdahl A., Goldstein M., Luft R., Efendic S., Nilsson G., Terenius L. Aminergic and peptidergic pathways in the nervous system with special reference to the hypothalamus. Res Publ Assoc Res Nerv Ment Dis. 1978;56:69–135. [PubMed] [Google Scholar]
- Jacobowitz D. M. Distribution of biogenic amines in the pituitary gland. Prog Brain Res. 1973;39:199–209. doi: 10.1016/S0079-6123(08)64077-7. [DOI] [PubMed] [Google Scholar]
- Jacobowitz D. M., Palkovits M. Topographic atlas of catecholamine and acetylcholinesterase-containing neurons in the rat brain. I. Forebrain (telencephalon, diencephalon). J Comp Neurol. 1974 Sep 1;157(1):13–28. doi: 10.1002/cne.901570103. [DOI] [PubMed] [Google Scholar]
- Lande S., Lerner A. B. The biochemistry of melanotropic agents. Pharmacol Rev. 1967 Mar;19(1):1–20. [PubMed] [Google Scholar]
- Oliver C., Porter J. C. Distribution and characterization of alpha-melanocyte-stimulating hormone in the rat brain. Endocrinology. 1978 Mar;102(3):697–705. doi: 10.1210/endo-102-3-697. [DOI] [PubMed] [Google Scholar]
- Palkovits M., Jacobowitz D. M. Topographic atlas of catecholamine and acetylcholinesterase-containing neurons in the rat brain. II. Hindbrain (mesencephalon, rhombencephalon). J Comp Neurol. 1974 Sep 1;157(1):29–42. doi: 10.1002/cne.901570104. [DOI] [PubMed] [Google Scholar]
- Pelletier G., Dube D. Electron microscopic immunohistochemical localization of alpha-msh in the rat brain. Am J Anat. 1977 Sep;150(1):201–205. doi: 10.1002/aja.1001500115. [DOI] [PubMed] [Google Scholar]
- Watson S. J., Barchas J. D., Li C. H. beta-Lipotropin: localization of cells and axons in rat brain by immunocytochemistry. Proc Natl Acad Sci U S A. 1977 Nov;74(11):5155–5158. doi: 10.1073/pnas.74.11.5155. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wimersma Greidanus T. B. Effects of MSH and related peptides on avoidance behavior in rats. Front Horm Res. 1977;4:129–139. doi: 10.1159/000400358. [DOI] [PubMed] [Google Scholar]