Abstract
Various classifications and representations of multilocus recombination structures are delineated based on generalized notions of linkage values and recombination rates. An important class of recombination distributions (called the count-location chiasma process) is parameterized by a distribution of the number of crossover events and, for each such crossover count, by a conditional distribution of crossover locations. A number of properties of this recombination structure are developed. A multilocus definition of a “natural” recombination range is set forth. Orderings among recombination distributions in the multilocus setting are also discussed. Comparisons are made in terms of complete linkage, free assortment and noninterference schemes serving as standards.
Keywords: linkage values, recombination-segregation distribution, nodule count-location processes, natural and more recombination
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Carpenter A. T. Electron microscopy of meiosis in Drosophila melanogaster females: II. The recombination nodule--a recombination-associated structure at pachytene? Proc Natl Acad Sci U S A. 1975 Aug;72(8):3186–3189. doi: 10.1073/pnas.72.8.3186. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Karlin S. General two-locus selection models: some objectives, results and interpretations. Theor Popul Biol. 1975 Jun;7(3):364–398. doi: 10.1016/0040-5809(75)90025-8. [DOI] [PubMed] [Google Scholar]
- OWEN A. R. G. The theory of genetical recombination. Adv Genet. 1950;3:117–157. doi: 10.1016/s0065-2660(08)60084-x. [DOI] [PubMed] [Google Scholar]
- SCHNELL F. W. Some general formulations of linkage effects in inbreeding. Genetics. 1961 Aug;46:947–957. doi: 10.1093/genetics/46.8.947. [DOI] [PMC free article] [PubMed] [Google Scholar]
- White R. L., Fox M. S. On the molecular basis of high negative interference. Proc Natl Acad Sci U S A. 1974 Apr;71(4):1544–1548. doi: 10.1073/pnas.71.4.1544. [DOI] [PMC free article] [PubMed] [Google Scholar]
- White R., Fox M. S. Genetic heterozygosity in unreplicated bacteriophage lambda recombinants. Genetics. 1975 Sep;81(1):33–50. doi: 10.1093/genetics/81.1.33. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zickler D. Development of the synaptonemal complex and the "recombination nodules" during meiotic prophase in the seven bivalents of the fungus Sordaria macrospora Auersw. Chromosoma. 1977 Jun 23;61(4):289–316. doi: 10.1007/BF00288615. [DOI] [PubMed] [Google Scholar]