Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1977 Jan;74(1):360–362. doi: 10.1073/pnas.74.1.360

Reduction of blood pressure and vascular collagen in hypertensive rats by beta-aminopropionitrile.

K Iwatsuki, G J Cardinale, S Spector, S Udenfriend
PMCID: PMC393260  PMID: 264688

Abstract

beta-Aminopropionitrile, a specific inhibitor of lysyl oxidase prevented the rise in blood pressure induced by deoxycorticosterone-salt in rats. In addition, after the onset of hypertension, administration of beta-aminopropionitrile lowered the blood pressure. Concomitant with the lowering of blood pressure, there was a reduction in the more highly crosslinked form of vascular collagen. These findings would indicate that increases in vascular connective tissue are not only sequelae of hypertension, but may also contribute to the maintenance of elevated blood pressure.

Full text

PDF
360

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bornstein P., Kang A. H., Piez K. A. The nature and location of intramolecular cross-links in collagen. Proc Natl Acad Sci U S A. 1966 Feb;55(2):417–424. doi: 10.1073/pnas.55.2.417. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Chvapil M., McCarthy D., Madden J. W., Peacock E. E., Jr Effect of 1,10-phenanthroline and desferrioxamine in vivo on prolyl hydroxylase and hydroxylation of collagen in various tissues of rats. Biochem Pharmacol. 1974 Aug;23(15):2165–2173. doi: 10.1016/0006-2952(74)90582-6. [DOI] [PubMed] [Google Scholar]
  3. DASLER W. Isolation of toxic crystals from sweet peas (Lathyrus odoratus). Science. 1954 Aug 20;120(3112):307–308. doi: 10.1126/science.120.3112.307. [DOI] [PubMed] [Google Scholar]
  4. GESSA G. L., CUENCA E., COSTA E. On the mechanism of hypotensive effects of MAO inhibitors. Ann N Y Acad Sci. 1963 Jul 8;107:935–944. doi: 10.1111/j.1749-6632.1963.tb13336.x. [DOI] [PubMed] [Google Scholar]
  5. Kivirikko K. I., Laitinen O., Prockop D. J. Modifications of a specific assay for hydroxyproline in urine. Anal Biochem. 1967 May;19(2):249–255. doi: 10.1016/0003-2697(67)90160-1. [DOI] [PubMed] [Google Scholar]
  6. LEVENE C. I., GROSS J. Alterations in state of molecular aggregation of collagen induced in chick embryos by beta-aminopropionitrile (lathyrus factor). J Exp Med. 1959 Nov 1;110:771–790. doi: 10.1084/jem.110.5.771. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Miller E. J., Pinnell S. R., Martin G. R., Schiffmann E. Investigation of the nature of the intermediates involved in desmosine biosynthesis. Biochem Biophys Res Commun. 1967 Jan 23;26(2):132–137. doi: 10.1016/0006-291x(67)90224-0. [DOI] [PubMed] [Google Scholar]
  8. Ooshima A., Fuller G. C., Cardinale G. J., Spector S., Udenfriend S. Increased collagen synthesis in blood vessels of hypertensive rats and its reversal by antihypertensive agents. Proc Natl Acad Sci U S A. 1974 Aug;71(8):3019–3023. doi: 10.1073/pnas.71.8.3019. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ooshima A., Fuller G., Cardinale G., Spector S., Udenfriend S. Collagen biosynthesis in blood vessels of brain and other tissues of the hypertensive rat. Science. 1975 Nov 28;190(4217):898–900. doi: 10.1126/science.171771. [DOI] [PubMed] [Google Scholar]
  10. PONSETI I. V., BAIRD W. A. Scoliosis and dissecting aneurysm of the aorta in rats fed with Lathyrus odoratus seeds. Am J Pathol. 1952 Nov-Dec;28(6):1059–1077. [PMC free article] [PubMed] [Google Scholar]
  11. Page R. C., Benditt E. P. Molecular diseases of connective and vascular tissues. II. Amine oxidase inhibition by the lathyrogen, beta-aminopropionitrile. Biochemistry. 1967 Apr;6(4):1142–1148. doi: 10.1021/bi00856a025. [DOI] [PubMed] [Google Scholar]
  12. Pinnell S. R., Martin G. R. The cross-linking of collagen and elastin: enzymatic conversion of lysine in peptide linkage to alpha-aminoadipic-delta-semialdehyde (allysine) by an extract from bone. Proc Natl Acad Sci U S A. 1968 Oct;61(2):708–716. doi: 10.1073/pnas.61.2.708. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Siegel R. C., Pinnell S. R., Martin G. R. Cross-linking of collagen and elastin. Properties of lysyl oxidase. Biochemistry. 1970 Nov 10;9(23):4486–4492. doi: 10.1021/bi00825a004. [DOI] [PubMed] [Google Scholar]
  14. Williams J. R., Harrison T. R., Grollman A. A SIMPLE METHOD FOR DETERMINING THE SYSTOLIC BLOOD PRESSURE OF THE UNANESTHETIZED RAT. J Clin Invest. 1939 May;18(3):373–376. doi: 10.1172/JCI101051. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. de Champlain J., Krakoff L. R., Axelrod J. Catecholamine metabolism in experimental hypertension in the rat. Circ Res. 1967 Jan;20(1):136–145. doi: 10.1161/01.res.20.1.136. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES