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. 1977 Jan;74(1):367–371. doi: 10.1073/pnas.74.1.367

Inhibition of erythrocyte sickling in vitro by DL-glyceraldehyde.

A M Nigen, J M Manning
PMCID: PMC393262  PMID: 264689

Abstract

Concentrations of DL-glyceraldehyde between 5 and 20 mM reduce the sickling of S/S erythrocytes even in the complete absence of oxygen; at 10 mM glyceraldehyde the increase in the number of normal cells ranges from 20 to 40%. The inhibition of sickling was both concentration- and time-dependent and was not reversed by repeated washings with buffer. Incubation of erythrocytes with increasing concentrations of glyceraldehyde resulted in only a small increase in the oxygen affinity, a moderate reduction in the Hill coefficient, a substantial increase in the minimum gelling concentration, and modification of up to two lysine residues per hemoglobin molecule.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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