TABLE 3.
Characteristics of Children Who Returned for Follow-Up at Age 7 Years
| Neonatal Characteristics | n = 101 | Lower Number of Invasive Procedures, Median 43, IQR 32–52 | Higher Number of Invasive Procedures, Median 127, 87–200 | P Value |
|---|---|---|---|---|
| n = 49 | n = 51 | |||
| Gestational age (wk), median (IQR) | 29.9 (27.5–31.7) | 31.6 (29.9–32.4) | 27.7 (26.3–29.3) | <0.001 |
| Small for gestational age, n (%) | 10 (10)a | 4 (8) | 6 (12) | 0.48 |
| Illness severity on day 1 (SNAP-II), median (IQR) | 9 (0–19)a | 5 (0–9) | 16 (8–25) | <0.001 |
| Invasive procedures (n), median (IQR) | 73 (43–129)a | — | — | |
| Surgery, n (%) | 17 (17)a | 1 (2) | 16 (31) | <0.001 |
| Infection, n (%) | 24 (24)a | 1 (2) | 23 (45) | <0.001 |
| Mechanical ventilation (days), median (IQR) | 2 (0–10)a | 0 (0–0) | 9 (3–31) | <0.001 |
| Dexamethasone or hydrocortisone, number exposed (%) | 8 (8) | 0 (0) | 8 (16) | <0.001 |
| Total morphine exposure (g/kg), median (IQR), number exposed (%) | 0.0 (0.0–0.6)a | 0.0 (0.0–0.0) | 0.6 (0.1–1.8) | 0.001 |
| 49 (49) | 6 (12) | 43 (84) | ||
| Total midazolam exposure (g/kg), median (IQR), number exposed (%) | 0.0 (0.0–0.0)a | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.02 |
| 8 (8) | 0 (0) | 8 (16) | ||
| Total fentanyl exposure (µg/kg), median (IQR), number exposed (%) | 0.0 (0.0–0.0)a | 0.0 (0.0–0.0) | 0.0 (0.0–3.0) | 0.04 |
| 12 (12) | 0 (0) | 12 (24) | ||
| Child Characteristics | n = 101 | n = 49 | n = 51 | P Value |
| Gender (male), n (%) | 50 (50) | 19 (39) | 31 (61) | 0.003 |
| Age at follow-up (y), median (IQR) | 7.6 (7.5–7.8) | 7.6 (7.5–7.7) | 7.6 (7.5–7.8) | 0.80 |
| WISC-IV FSIQ, median (IQR) | 100 (91–110)b | 104 (94–114) | 95 (87–108) | 0.009 |
| WISC-IV VCI, median (IQR) | 98 (93–108)b | 99 (95–114) | 98 (89–104) | 0.09 |
| WISC-IV PRI, median (IQR) | 100 (92–116)b | 104 (98–117) | 100 (88–110) | 0.07 |
| WISC-IV WMI, median (IQR) | 97 (88–110)b | 99 (91–110) | 94 (88–108) | 0.10 |
| WISC-IV PSI, median (IQR) | 94 (85–106)b | 100 (90–113) | 88 (83–99) | 0.003 |
a
1 child was missing neonatal data, and 2 children did not have neonatal infection data.
b
4 children did not complete the FSIQ, 2 children did not complete the VCI, 1 child did not complete the PRI, 3 children did not complete the WMI, and 6 children did not complete the PRI.