Table 1.

Genotype and Phenotype Characteristics of Human Liver Microsome Specimens

HLM ID	Drug exposure	Gender	CYP2B6 Genotype	CYP2C19 Genotype	CYP2B6 (pmol/mg)	Bupropion Hydroxylation Activity (pmol/min/mg OH-Bupropion formation)
1	Yes	female	*1/*1	*1/*1	6.21	86.22
2	P450 inducer	male	*1/*1	*1/*1	6.59	115.66
3	Yes	female	*1/*1	*1/*1	8.00	194.13
4	Yes	male	*1/*1	*1/*1	8.30	152.30
5	Yes	female	*1/*1	*1/*1	8.40	218.73
6	No	female	*1/*1	*1/*1	17.36	119.60
7	Yes	male	*1/*1	*1/*1	22.94	232.46
8	Yes	male	*1/*1	*1/*1	25.43	148.65
9	Yes	male	*1/*1	*1/*1	44.26	158.33
10	No	male	*1/*1	*1/*1	75.91	1204.93
11	N/A	male	*1/*1	*1/*1	100.76	752.41
12	P450 inducer	male	*6/*6	*1/*1	1.50	14.70
13	No	female	*6/*6	*1/*2	2.11	10.53
14	Yes	male	*6/*6	*1/*2	2.56	41.36
15	No	female	*6/*6	*1/*1	4.51	71.66
16	P450 inducer	female	*6/*6	*1/*1	5.00	56.18
17	No	male	*6/*6	*1/*1	7.30	124.26
18	No	female	*6/*6	*1/*1	11.04	57.76
19	Yes	male	*1/*1	*2/*2	19.05	76.40
20	Yes	female	*1/*1	*2/*2	24.45	105.88
21	P450 inducer	male	*1/*1	*2/*2	28.27	280.67
22	No	male	*1/*1	*2/*2	54.95	578.60

Genotype and phenotype characteristics of the 22 individual HLMs used. Original ID numbers were changed to a simple numbering system. Drug exposure indicates whether liver donors were exposed to known P450 inducers (omeprazole, pantoprazole, budenosid); the other patients received either no drugs or drugs not known to induce P450 prior to surgery; N/A., not available.