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. 1983 Feb;80(4):1116–1119. doi: 10.1073/pnas.80.4.1116

N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain "glutamate" receptor.

R Zaczek, K Koller, R Cotter, D Heller, J T Coyle
PMCID: PMC393539  PMID: 6302671

Abstract

A brain peptide with high affinity (420 nM) and marked specificity for brain receptor sites labeled with L-[3H]glutamate has been identified. Amino acid analysis and mass spectroscopy indicate that the peptide is N-acetylaspartylglutamate. The peptide exhibits potent convulsant properties when injected into the rat hippocampus, similar to those produced by the glutamate receptor agonist, quisqualic acid. These findings raise the question whether endogenous brain peptides enriched in acidic amino acids may serve as excitatory neurotransmitters.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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