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. 1996 May 14;93(10):4862–4867. doi: 10.1073/pnas.93.10.4862

Crystal structure of a human TATA box-binding protein/TATA element complex.

D B Nikolov 1, H Chen 1, E D Halay 1, A Hoffman 1, R G Roeder 1, S K Burley 1
PMCID: PMC39370  PMID: 8643494

Abstract

The TATA box-binding protein (TBP) is required by all three eukaryotic RNA polymerases for correct initiation of transcription of ribosomal, messenger, small nuclear, and transfer RNAs. The cocrystal structure of the C-terminal/core region of human TBP complexed with the TATA element of the adenovirus major late promoter has been determined at 1.9 angstroms resolution. Structural and functional analyses of the protein-DNA complex are presented, with a detailed comparison to our 1.9-angstroms resolution structure of Arabidopsis thaliana TBP2 bound to the same TATA box.

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Selected References

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