There is a mistake in the alignment of the Drosophila Greatwall sequence in Figure 2A.
The correct Drosophila sequence is: fglskidmrrdleisdlincspnlnartpgqllsltshlsfgsekklndfgsvssgqnngmg
This sequence does not contain a conserved TTP Cdk consensus site at the residues equivalent to the human Threonine 193 and 194.
Note that there is a TP in this sequence, which could be a relevant Cdk phosphorylation site.
This requires further experimental evidence.
Reference
- 1. Hégarat N, Vesely C, Vinod PK, Ocasio C, Peter N, et al. (2014) PP2A/B55 and Fcp1 Regulate Greatwall and Ensa Dephosphorylation during Mitotic Exit. PLoS Genet 10(1): e1004004 doi:10.1371/journal.pgen.1004004 [DOI] [PMC free article] [PubMed] [Google Scholar]