Table 4. Univariate and Multivariable Hazard Ratios and 95% CI for the development of POAG.
| Univariate | Multivariable* | |||
|---|---|---|---|---|
| Hazard Ratio (95% CI) | Hazard Ratio (95% CI) | |||
| Moorfields Regression Analysis (outside normal limits versus not) | Result | 4.34 (2.40 7.84) | 3.90 (2.09 7.28) | |
| Global | 6.92 (3.09 15.49) | 6.29 (2.84 13.99) | ||
| Nasal | 4.10 (2.14 7.87) | 4.35 (2.07 9.15) | ||
| Nasal Inferior | 5.83 (2.93 11.61) | 4.71 (2.26 9.16) | ||
| Nasal Superior | 3.75 (1.67 8.42) | 3.34 (1.54 7.60) | ||
| Temporal | 1.89 (0.26 13.69) | 2.41 (0.36 16.00) | ||
| Temporal Inferior | 5.20 (2.03 13.31) | 3.84 (1.16 12.70) | ||
| Temporal Superior | 14.25 (6.57 30.90) | 11.03 (4.81 25.30) | ||
|
OHTS Predictive Factors |
Age (per decade) | 1.38 (1.03 1.84) | NA | |
| History of heart disease | 2.81 (1.14 6.94) | NA | ||
| IOPˆ (per mm Hg) | 1.12 (1.02 1.24) | NA | ||
| Central Corneal Thickness (per 40 μm thinner) | 1.60 (1.18 2.18) | NA | ||
| PSDˆˆ (per 0.2 dB greater) | 1.04 (1.00 1.07) | NA | ||
| Photograph Horizontal cup-to--disc ratio closest to HRTˆˆˆ baseline (per 0.1 larger) | 1.38 (1.21 1.58) | NA | ||
| CSLO Measures | Disc area (per 0.4 mm2 greater) | 0.94 (0.73 1.23) | 0.99 (0.74 1.32) | |
| Cup area (per 0.3 mm2 greater) | 1.46 (1.22 1.74) | 1.47 (1.21 1.79) | ||
| Cup area-to-disc area (per 0.1 greater) | 1.66 (1.39 1.98) | 1.64 (1.36 1.96) | ||
| Linear cup-to-disc ratio (per 0.1 greater) | 1.74 (1.38 2.19) | 1.71 (1.36 2.15) | ||
| Mean Cup depth (per 0.1 mm greater) | 1.85 (1.45 2.35) | 1.93 (1.50 2.49) | ||
| RNFL thickness (per 0.1 mm greater) | 0.43 (0.27 0.71) | 0.49 (0.29 0.84) | ||
| Standard deviation of mean image (per 6 μm greater) | 1.21 (1.00 1.47) | 1.16 (0.96 1.41) | ||
| Cup shape (per 0.1 greater) | 1.57 (1.13 2.17) | 1.33 (0.94 1.88) | ||
| Cup volume below surface (per 0.1 mm3 greater) | 1.21 (1.09 1.34) | 1.22 (1.10 1.36) | ||
| Rim area (per 0.2 greater) | 0.46 (0.36 0.50) | 0.46 (0.36 0.59) | ||
| Rim area/disc area (per 0.1 greater) | 0.60 (0.50 0.72) | 0.61 (0.51 0.73) | ||
| Reference height (per 0.1 mm greater) | 1.27 (1.00 1.62) | 1.34 (1.02 1.75) | ||
| Corneal curvature (per 0.2 mm greater) | 1.17 (0.95 1.45) | 1.13 (0.91 1.40) | ||
| RNFL cross section (per 0.3 mm2 greater) | 0.58 (0.43 0.77) | 0.62 (0.45 0.85) | ||
| Mean height contour (per 0.1 mm greater) | 2.61 (1.86 3.67) | 2.64 (1.86 3.73) | ||
| Rim volume above ref (per 0.1 mm3 greater) | 0.50 (0.37 0.68) | 0.53 (0.39 0.72) | ||
| Cup volume below ref (per 0.1 mm3 greater) | 1.40 (1.22 1.59) | 1.40 (1.23 1.60) | ||
Abbreviations: POAG= primary open-angle glaucoma; IOP =Intraocular pressure; CI=Confidence Interval; PSD = Pattern Standard Deviation; HRT = Heidelberg Retina Tomograph; RNFL = Retinal Nerve Fiber Layer; CSLO = Confocal Scanning Laser Ophthalmoscopy; OHTS = Ocular Hypertension Treatment Study; NA= not applicable
*
Multivariable model contains baseline age, intraocular pressure, visual field pattern standard devision, central corneal thickness with medication status as a time dependent covariate. 64 eyes were excluded from the multivariable analyses due to missing central corneal thickness values.