Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1996 May 14;93(10):4962–4967. doi: 10.1073/pnas.93.10.4962

Electrical microstimulation suggests two different forms of representation of head-centered space in the intraparietal sulcus of rhesus monkeys.

P Thier 1, R A Andersen 1
PMCID: PMC39388  PMID: 8643512

Abstract

We examined the effects of eye position on saccades evoked by electrical stimulation of the intraparietal sulcus (IPS) of rhesus monkeys. Microstimulation evoked saccades from sites on the posterior bank, floor, and the medial bank of the IPS. The size and direction of the eye movements varied as a function of initial eye position before microstimulation. At many stimulation sites, eye position affected primarily the amplitude and not the direction of the evoked saccades. These "modified vector saccades" were characteristic of most stimulation-sensitive zones in the IPS, with the exception of a narrow strip located mainly on the floor of the sulcus. Stimulation in this "intercalated zone" evoked saccades that moved the eyes into a particular region in head-centered space, independent of the starting position of the eyes. This latter response is compatible with the stimulation site representing a goal zone in head-centered coordinates. On the other hand, the modified vector saccades observed outside the intercalated zone are indicative of a more distributed representation of head-centered space. A convergent projection from many modified vector sites onto each intercalated site may be a basis for a transition from a distributed to a more explicit representation of space in head-centered coordinates.

Full text

PDF
4962

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersen R. A., Bracewell R. M., Barash S., Gnadt J. W., Fogassi L. Eye position effects on visual, memory, and saccade-related activity in areas LIP and 7a of macaque. J Neurosci. 1990 Apr;10(4):1176–1196. doi: 10.1523/JNEUROSCI.10-04-01176.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Barash S., Bracewell R. M., Fogassi L., Gnadt J. W., Andersen R. A. Saccade-related activity in the lateral intraparietal area. I. Temporal properties; comparison with area 7a. J Neurophysiol. 1991 Sep;66(3):1095–1108. doi: 10.1152/jn.1991.66.3.1095. [DOI] [PubMed] [Google Scholar]
  3. Barash S., Bracewell R. M., Fogassi L., Gnadt J. W., Andersen R. A. Saccade-related activity in the lateral intraparietal area. II. Spatial properties. J Neurophysiol. 1991 Sep;66(3):1109–1124. doi: 10.1152/jn.1991.66.3.1109. [DOI] [PubMed] [Google Scholar]
  4. Blatt G. J., Andersen R. A., Stoner G. R. Visual receptive field organization and cortico-cortical connections of the lateral intraparietal area (area LIP) in the macaque. J Comp Neurol. 1990 Sep 22;299(4):421–445. doi: 10.1002/cne.902990404. [DOI] [PubMed] [Google Scholar]
  5. Bon L., Lucchetti C. The dorsomedial frontal cortex of the macaca monkey: fixation and saccade-related activity. Exp Brain Res. 1992;89(3):571–580. doi: 10.1007/BF00229882. [DOI] [PubMed] [Google Scholar]
  6. Colby C. L., Duhamel J. R., Goldberg M. E. Ventral intraparietal area of the macaque: anatomic location and visual response properties. J Neurophysiol. 1993 Mar;69(3):902–914. doi: 10.1152/jn.1993.69.3.902. [DOI] [PubMed] [Google Scholar]
  7. Guitton D., Crommelinck M., Roucoux A. Stimulation of the superior colliculus in the alert cat. I. Eye movements and neck EMG activity evoked when the head is restrained. Exp Brain Res. 1980;39(1):63–73. doi: 10.1007/BF00237070. [DOI] [PubMed] [Google Scholar]
  8. Hepp K., Henn V. Extraocular motoneuron behavior in synergistic action. Prog Brain Res. 1986;64:31–38. doi: 10.1016/S0079-6123(08)63397-X. [DOI] [PubMed] [Google Scholar]
  9. Kurylo D. D., Skavenski A. A. Eye movements elicited by electrical stimulation of area PG in the monkey. J Neurophysiol. 1991 Jun;65(6):1243–1253. doi: 10.1152/jn.1991.65.6.1243. [DOI] [PubMed] [Google Scholar]
  10. Mann S. E., Thau R., Schiller P. H. Conditional task-related responses in monkey dorsomedial frontal cortex. Exp Brain Res. 1988;69(3):460–468. doi: 10.1007/BF00247300. [DOI] [PubMed] [Google Scholar]
  11. Maunsell J. H., van Essen D. C. The connections of the middle temporal visual area (MT) and their relationship to a cortical hierarchy in the macaque monkey. J Neurosci. 1983 Dec;3(12):2563–2586. doi: 10.1523/JNEUROSCI.03-12-02563.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. McIlwain J. T. Effects of eye position on saccades evoked electrically from superior colliculus of alert cats. J Neurophysiol. 1986 Jan;55(1):97–112. doi: 10.1152/jn.1986.55.1.97. [DOI] [PubMed] [Google Scholar]
  13. Mitz A. R., Wise S. P. The somatotopic organization of the supplementary motor area: intracortical microstimulation mapping. J Neurosci. 1987 Apr;7(4):1010–1021. doi: 10.1523/JNEUROSCI.07-04-01010.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Ohtsuka K., Edamura M., Kawahara K., Aoki M. The properties of goal-directed eye movements evoked by microstimulation of the cerebellar vermis in the cat. Neurosci Lett. 1987 May 6;76(2):173–178. doi: 10.1016/0304-3940(87)90711-7. [DOI] [PubMed] [Google Scholar]
  15. ROBINSON D. A. A METHOD OF MEASURING EYE MOVEMENT USING A SCLERAL SEARCH COIL IN A MAGNETIC FIELD. IEEE Trans Biomed Eng. 1963 Oct;10:137–145. doi: 10.1109/tbmel.1963.4322822. [DOI] [PubMed] [Google Scholar]
  16. ROBINSON D. A. THE MECHANICS OF HUMAN SACCADIC EYE MOVEMENT. J Physiol. 1964 Nov;174:245–264. doi: 10.1113/jphysiol.1964.sp007485. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Robinson D. A. Eye movements evoked by collicular stimulation in the alert monkey. Vision Res. 1972 Nov;12(11):1795–1808. doi: 10.1016/0042-6989(72)90070-3. [DOI] [PubMed] [Google Scholar]
  18. Roucoux A., Guitton D., Crommelinck M. Stimulation of the superior colliculus in the alert cat. II. Eye and head movements evoked when the head is unrestrained. Exp Brain Res. 1980;39(1):75–85. doi: 10.1007/BF00237071. [DOI] [PubMed] [Google Scholar]
  19. Russo G. S., Bruce C. J. Effect of eye position within the orbit on electrically elicited saccadic eye movements: a comparison of the macaque monkey's frontal and supplementary eye fields. J Neurophysiol. 1993 Mar;69(3):800–818. doi: 10.1152/jn.1993.69.3.800. [DOI] [PubMed] [Google Scholar]
  20. Schall J. D. Neuronal activity related to visually guided saccades in the frontal eye fields of rhesus monkeys: comparison with supplementary eye fields. J Neurophysiol. 1991 Aug;66(2):559–579. doi: 10.1152/jn.1991.66.2.559. [DOI] [PubMed] [Google Scholar]
  21. Schlag J., Schlag-Rey M. Evidence for a supplementary eye field. J Neurophysiol. 1987 Jan;57(1):179–200. doi: 10.1152/jn.1987.57.1.179. [DOI] [PubMed] [Google Scholar]
  22. Shibutani H., Sakata H., Hyvärinen J. Saccade and blinking evoked by microstimulation of the posterior parietal association cortex of the monkey. Exp Brain Res. 1984;55(1):1–8. doi: 10.1007/BF00240493. [DOI] [PubMed] [Google Scholar]
  23. Tehovnik E. J., Lee K. The dorsomedial frontal cortex of the rhesus monkey: topographic representation of saccades evoked by electrical stimulation. Exp Brain Res. 1993;96(3):430–442. doi: 10.1007/BF00234111. [DOI] [PubMed] [Google Scholar]
  24. WAGMAN I. H., WERMAN R., FELDMAN D. S., SUGARMAN L., KRIEGER H. P. The oculomotor effects of cortical and subcortical stimulation in the monkey. J Neuropathol Exp Neurol. 1957 Apr;16(2):269–277. doi: 10.1097/00005072-195704000-00006. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES