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. 1983 May;80(9):2628–2631. doi: 10.1073/pnas.80.9.2628

Unusual human interferons produced by virus-infected amniotic membranes.

P Duc-Goiran, B Robert-Galliot, T Chudzio, C Chany
PMCID: PMC393880  PMID: 6189128

Abstract

Interferon (IFN) induced in the human amniotic membrane contains at least five different molecular species, as shown by analysis in NaDodSO4/polyacrylamide gels after heating and under reducing conditions. Three of the IFN components reported here--migrating at 26, 43, and 80 kilodaltons--are of unusual antigenic structure because they are neutralized to about the same extent by anti-IFN-alpha and anti-IFN-beta antibodies. The 15- to 17-kilodalton species belongs to the IFN-alpha group, while the 21- to 22-kilodalton species, the most frequently detected major peak, is IFN-beta. In addition to their unusual size and antigenic structure, these IFNs could play a role during embryonic development and in the immune tolerance of the mother with regard to the fetus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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