Table 2.
Change in Pulmonary Physiology, Exercise Capacity, Muscle Strength, lower extremity functioning, COPD Severity Score, and BMI from baseline to follow-up (N=609)
| Subject Characteristics | mean ± SD | p-value |
|---|---|---|
| FEV1 in liters | −0.10 ± 0.25 | <0.0001 |
| FEV1 % predicted | −1.9 ± 8.7 | <0.0001 |
| Six minute walk distance, in meters | −36.1 ± 84.1 | <0.0001 |
| Quadriceps (kilograms of force) | 0.8 ± 7.5 | 0.01 |
| Quadriceps % predicted† | 1.8 ± 23.0 | 0.01 |
| Short Physical Performance Battery | 0.1 ± 1.5 | 0.02 |
| COPD Severity Score | 0.1 ± 4.7 | 0.70 |
| BMI | −0.2 ± 3.2 | 0.15 |
*
FEV1 % predicted values derived directly from the linear regression equations developed from the National Health and Nutrition Examination Survey (NHANES III).22
†
Muscle strength % predicted values generated from 302 age and sex matched control subjects without COPD employing linear regression controlling for age, gender, body mass index (BMI), and height.8