Table 1.
Frequency counts for genotypes by virologic responder status1 and minor allele frequencies by self-reported race/ethnic group in 91 HIV-infected women treated with NNRTIs (efavirenz or nevirapine).
| Minor Allele Frequency | ||||||
|---|---|---|---|---|---|---|
| CYP2B6 SNP2 | Responders (%) | Non-responders (%) | African American (n=55) | White (n=22) | Hispanic (n=8) | Other3 (n=6) |
| rs3211371 | 0.03 | 0.07 | 0 | 0 | ||
| CC | 63 (90) | 21 (100) | ||||
| CT | 6 (10) | 0 | ||||
| TT | 0 | 0 | ||||
| missing | 1 | 0 | ||||
| rs3409703 | 0.22 | 0 | 0 | 0.08 | ||
| TT | 52 (76) | 14 (74) | ||||
| TC | 16 (24) | 4 (21) | ||||
| CC | 0 | 1 (5) | ||||
| missing | 2 | 2 | ||||
| rs1042389 | 0.25 | 0.14 | 0.21 | 0.08 | ||
| TT | 46 (66) | 13 (62) | ||||
| TC | 21 (30) | 7 (33) | ||||
| CC | 3 (4) | 1 (5) | ||||
| rs8192709 | 0.06 | 0 | 0.07 | 0 | ||
| CC | 64 (91) | 20 (95) | ||||
| CT | 6 (9) | 1 (5) | ||||
| TT | 0 | 0 | ||||
| rs3745274 | 0.28 | 0.24 | 0.21 | 0.33 | ||
| GG | 32 (46) | 14 (67) | ||||
| GT | 34 (48) | 7 (33) | ||||
| TT | 4 (6) | 0 | ||||
| rs28399499 | 0.10 | 0 | 0 | 0 | ||
| TT | 62 (88) | 19 (90) | ||||
| TC | 7 (10) | 2 (10) | ||||
| CC | 1 (2) | 0 | ||||
1
Virologic response defined as achievement of undetectable viral load up to 54 weeks after self- reported initiation of NNRTI-based regimen
2
SNP= single nucleotide polymorphism; all SNPs are missense with the exception of rs1042389 which is located in the 3′ untranslated region
3
Asian, Native American, Other