Knockout of macrophage geranylgeranyltransferase type I (GGTase-I) reduces atherosclerosis development in Ldlr-deficient mice. A, Quantification of lipid lesions in aortas of Pggt1b+/+ and Pggt1b∆/∆ mice fed a high-fat diet for 12 and 24 weeks. Right, Representative photographs of aortas. B, Body weight curves of Pggt1b+/+ mice (n=11) and Pggt1b∆/∆ mice (n=13) fed a high-fat diet. C, Plasma cholesterol (Chol) and triglyceride (TG) levels. Numbers in bars indicate the number of mice. D, Cholesterol and triglyceride levels in fast protein liquid chromatography–fractionated plasma pooled from 10 mice per genotype. The mice were fed a high-fat diet for 12 weeks. HDL indicates high-density lipoprotein; IDL, intermediate-density lipoprotein; LDL, low-density lipoprotein; and VLDL, very-low-density lipoprotein.