Table 3.
Association between polymorphisms in Wnt signaling pathway genes and renal cancer
| Gene polymorphism | Genotype | renal cancer (n=210) | control (n=200) | OR (95% CI) | p-value | FDR adjusted p-value* |
|---|---|---|---|---|---|---|
| n (%) | n (%) | |||||
| DKK2 (rs17037102) | GG | 105 (50) | 106 (53) | 1 (reference) | ||
| GA | 92 (44) | 82 (41) | 1.13 (0.76–1.69) | 0.54 | ||
| AA | 12 (6) | 12 (06) | 1.01 (0.43–2.34) | 0.98 | ||
| GA+AA | 104 (50) | 94 (47) | 1.11 (0.76–1.65) | 0.57 | 0.61 | |
| DKK2 (rs419558) | CC | 119 (57) | 88 (44) | 1 (reference) | ||
| CT | 63 (30) | 88 (44) | 0.53 (0.34–0.81) | 0.003 | ||
| TT | 28 (13) | 24 (12) | 0.86 (0.45–1.58) | 0.64 | ||
| CT+TT | 91 (43) | 112 (56) | 0.60 (0.41–0.88) | 0.01 | 0.028a | |
| DKK2 (rs447372) | GG | 117 (56) | 88 (44) | 1 (reference) | ||
| GA | 65 (31) | 88 (44) | 0.56 (0.36–0.84) | 0.0063 | ||
| AA | 28 (13) | 24 (12) | 0.88 (0.47–1.62) | 0.67 | ||
| GA+AA | 93 (44) | 112 (56) | 0.62 (0.42–0.92) | 0.01 | 0.0238a | |
| DKK3 (rs3206824) | GG | 150 (71) | 104 (52) | 1 (reference) | ||
| GA | 53 (25) | 82 (41) | 0.45 (0.29–0.69) | 0.0001 | ||
| AA | 7 (4) | 14 (7) | 0.35 (0.14–0.89) | 0.02 | ||
| GA+AA | 60 (29) | 96 (48) | 0.43 (0.29–0.65) | 0.0001 | 0.0014a | |
| DKK3 (rs11022095) | GG | 28 (13) | 23 (11) | 1 (reference) | ||
| GA | 88 (42) | 87 (44) | 0.83 (0.44–1.55) | 0.56 | ||
| AA | 94 (45) | 90 (45) | 0.85 (0.46–1.59) | 0.63 | ||
| GA+AA | 182 (87) | 177 (89) | 0.84 (0.47–1.52) | 0.57 | 0.57 | |
| DKK3 (rs1472189) | CC | 155 (74) | 134 (67) | 1 (reference) | ||
| CT | 51 (24) | 59 (30) | 0.74 (0.48–1.16) | 0.19 | ||
| TT | 4 (2) | 7 (3) | 0.49 (0.14–1.72) | 0.26 | ||
| CT+TT | 55 (26) | 66 (33) | 0.72 (0.47–1.10) | 0.13 | 0.18 | |
| DKK3 (rs7396187) | GG | 138 (66) | 102 (51) | 1 (reference) | ||
| GC | 58 (27) | 75 (38) | 0.57 (0.37–0.88) | 0.01 | ||
| CC | 14 (7) | 23 (11) | 0.45 (0.22–0.92) | 0.02 | ||
| GC+CC | 72 (34) | 98 (49) | 0.54 (0.37–0.81) | 0.002 | 0.01a | |
| DKK3 (rs2291599) | CC | 101 (48) | 113 (57) | 1 (reference) | ||
| CT | 81 (39) | 62 (31) | 1.46 (0.95–2.24) | 0.08 | ||
| TT | 28 (13) | 25 (12) | 1.25 (0.69–2.29) | 0.46 | ||
| CT+TT | 109 (52) | 87 (43) | 1.41 (0.95–2.07) | 0.08 | 0.14 | |
| DKK4 (rs2073664) | CC | 144 (68) | 145 (72) | 1 (reference) | ||
| CT | 40 (19) | 46 (23) | 0.88 (0.54–1.42) | 0.58 | ||
| TT | 26 (13) | 9 (5) | 2.91 (1.32–6.42) | 0.006 | ||
| CT+TT | 66 (32) | 55 (28) | 1.21 (0.79–1.85) | 0.38 | 0.48 | |
| sFRP4 (rs1802073) | CC | 51 (24) | 36 (18) | 1 (reference) | ||
| CA | 82 (39) | 112 (56) | 0.52 (0.31–0.86) | 0.01 | ||
| AA | 77 (37) | 52 (26) | 1.04 (0.61–1.82) | 0.87 | ||
| CA+A | 159 (76) | 164 (82) | 0.68 (0.42–1.11) | 0.12 | 0.19 | |
| sFRP4 (rs1802074) | AA | 36 (17) | 18 (9) | 1 (reference) | ||
| AG | 69 (33) | 69 (34) | 0.51 (0.26–0.96) | 0.04 | ||
| GG | 105 (50) | 113 (56) | 0.46 (0.25–0.87) | 0.01 | ||
| AG+GG | 174 (83) | 182 (91) | 0.48 (0.26–0.87) | 0.01 | 0.04a | |
| SMAD7 (rs12953717) | CC | 125 (59) | 139 (70) | 1 (reference) | ||
| CT | 68 (32) | 48 (24) | 1.57 (1.01–2.45) | 0.04 | ||
| TT | 17 (9) | 13 (6) | 1.45 (0.68–3.11) | 0.33 | ||
| CT+TT | 85 (41) | 61 (30) | 1.55 (1.03–2.33) | 0.03 | 0.06 | |
| DAAM2 (rs6937133) | GG | 30 (14) | 33 (16) | 1 (reference) | ||
| GA | 65 (31) | 65 (33) | 1.1(0.61–2.01) | 0.75 | ||
| AA | 115 (55) | 102 (51) | 1.24 (0.71–2.17) | 0.45 | ||
| GA+AA | 180 (86) | 167 (84) | 1.18 (0.69–2.03) | 0.53 | 0.62 | |
| DAAM2 (rs2504106) | TT | 72 (34) | 37 (17) | 1 (reference) | ||
| TC | 84 (40) | 118 (59) | 0.36 (0.23–0.59) | 0.0001 | ||
| CC | 54 (26) | 45 (23) | 0.62 (0.35–1.08) | 0.08 | ||
| TC+CC | 138 (66) | 163 (82) | 0.44 (0.28–0.69) | 0.0002 | 0.0014a | |
Note; FDR means false discovery rate, FDR adjusted P value using the Benjamini-Hochberg methods.
FDR adjusted p-value of < 0.05 was regarded as statistically significant,
a
Remain significant after FDR adjustment