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A TL-OCT time sequence of OVCAR5 ovarian cancer 3D nodules following photodynamic therapy (PDT) with the PS EtNBS-OH at 20 J/cm2. In the time sequence, nodules are observed to undergo “unpacking” as they undergo structural degradation. The backscattering intensity of individual cells increases in the hours following PDT as cells in the spheroid undergo apoptosis.
