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DNA-PKcs deficiency renders cells resistant to paclitaxel. (a) HCT116 and DNA-PKcs−/− cells were treated with indicated concentrations of paclitaxel and were analyzed for clonal survival ability. (b) HCT116 and DNA-PKcs−/− cells were treated with paclitaxel for 72 h, and viability was determined using an MTT assay. ***P<0.001; ****P<0.0001.
