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. 1983 Jun;80(12):3807–3811. doi: 10.1073/pnas.80.12.3807

Analysis of cell surface proteins delineates a differentiation pathway linking endocrine and nonendocrine human lung cancers.

G Goodwin, J H Shaper, M D Abeloff, G Mendelsohn, S B Baylin
PMCID: PMC394141  PMID: 6304739

Abstract

We have previously determined that the cell surface protein phenotype distinguishes human small cell lung carcinoma (SCC), a neoplasm with endocrine properties, from non-SCC in culture. We now demonstrate that cloned cell cultures of human large cell undifferentiated lung carcinoma, established directly from a patient with mixed SCC and non-SCC, simultaneously express surface proteins characteristic of SCC and non-SCC lung cancer cells. Hence, SCC and a form of large cell carcinoma appear linked through a continuum of differentiation events that: (i) may explain clinically important transitions that occur between the major types of human lung cancer and (ii) provide evidence for a common cellular origin of endocrine and nonendocrine cells in the bronchial mucosa.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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