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. 1983 Jul;80(13):4060–4064. doi: 10.1073/pnas.80.13.4060

Comparison of maxicircle DNAs of Leishmania tarentolae and Trypanosoma brucei.

M L Muhich, L Simpson, A M Simpson
PMCID: PMC394200  PMID: 6306661

Abstract

The conserved portions of the maxicircle DNAs of Leishmania tarentolae and Trypanosoma brucei are organized in a basically colinear manner over a 15- to 17-kilobase region that is interrupted by two small less-homologous sequences. The most highly conserved regions are those encoding the 9S and 12S genes. An approximately 12-kilobase region directly upstream of the 12S gene in the L. tarentolae maxicircle showed no sequence homology with the T. brucei maxicircle and also was not transcribed. An approximately 6-kilobase region in the T. brucei maxicircle in the same relative location also showed no sequence homology with the L. tarentolae maxicircle. We propose that evolution of maxicircle DNA occurs mainly within this "divergent region."

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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