Table 1.

Comparison of various Cre and inducible Cre lines with reported Cre activity in the CCS.

Cre lines	Cre activity				KI	BAC	Leaky	other cardiac expression	reference
	SAN	AVN	His/BB	Purkinje
Hcn4-CreERT2	+	+	+	+	yes	no	no	no	Hoesl et al., 2008
Hcn4-CreERT2	+	+	+	+	yes	no	no	no	Liang et al. 2013
Cx40-CreERT2	−	−	+	+	yes	no	no	yes	Beyer et al., 2011
minK-CreERT2	−	+	+	+	no	yes	yes	no	Arnolds et al., 2011
Shox2-Cre	+	n/a	+/−	−	yes	no	−	n/a	Sun et al., 2013
Hcn4-CreERT2	+	+	+	+	no	yes	no	no	This report

SAN: sinoatrial node; AVN: atrioventricular node; BB: bundle branches; KI: knockin