Table 3. Locations of Brain Regions Comprising Spatially Independent Networks (IC 6, 12, 19) of Activity Associated with the Contrast of Cocaine-Related and Neutral Cues in Cocaine-Dependent Individualsa.

Region (Brodmann area)	Cluster size (voxels)	Peak voxel t-score	Peak voxel MNI coordinates
			x	y	z
Component 6
Left postcentral gyrus (1, 2)	1515	11.67	−40	−20	44
Left insula	—	8.18	−40	−18	20
Transverse temporal gyrus (41)	—	10.62	−56	−14	12
Right insula	1159	12.58	38	−17	18
Right postcentral gyrus (43)	—	10.19	62	−11	15
Right precentral gyrus (6)	—	11.40	53	−14	36
Superior temporal gyrus (22)	—	6.94	65	−32	6
Left inferior frontal gyrus (47)	50	−7.80	−46	20	0
Right inferior frontal gyrus (47)	48	−8.10	28	22	−6
Supplementary motor area (6)	45	6.65	2	−11	66
Paracentral lobule (5)	24	7.48	−2	−38	60
Component 12
Left inferior frontal gyrus (45)	2455	14.48	−52	22	12
Dorsomedial prefrontal (9)	—	12.64	−4	50	38
Left middle frontal gyrus (6)	—	12.01	−44	10	50
Left middle temporal gyrus (21)	1382	14.31	−64	−29	−4
Left superior temporal gyrus (39)	—	12.48	−54	−62	26
Right middle frontal gyrus (9)	408	−10.33	40	40	30
Left precuneus (7)	271	9.89	−4	−52	36
Right superior occipital gyrus (19)	155	−7.26	22	−74	36
Right inferior frontal gyrus (45)	136	9.46	50	28	−4
Right middle temporal gyrus (21)	133	7.48	50	−62	24
Component 19
Left inferior frontal gyrus (45)	1151	12.48	−46	16	2
Left middle frontal gyrus (9)	—	7.12	−32	50	32
Left insula	—	10.81	−40	−10	−2
Right inferior frontal gyrus (47)	1033	11.81	40	20	−4
Right insula	—	9.07	40	−12	−4
Right supramarginal gyrus (40)	622	11.16	58	−44	30
Right middle temporal (22)	—	7.88	46	−46	8
Dorsal anterior cingulate cortex (32)	552	9.33	−2	22	42
Left superior frontal gyrus (9)	58	7.11	−32	50	32

^aComponents thresholded at |t|>5 and minimum cluster size of 20 contiguous voxels.