Table 3. Locations of Brain Regions Comprising Spatially Independent Networks (IC 6, 12, 19) of Activity Associated with the Contrast of Cocaine-Related and Neutral Cues in Cocaine-Dependent Individualsa.
Region (Brodmann area) | Cluster size (voxels) | Peak voxel t-score |
Peak voxel MNI coordinates |
||
---|---|---|---|---|---|
x | y | z | |||
Component 6 | |||||
Left postcentral gyrus (1, 2) | 1515 | 11.67 | −40 | −20 | 44 |
Left insula | — | 8.18 | −40 | −18 | 20 |
Transverse temporal gyrus (41) | — | 10.62 | −56 | −14 | 12 |
Right insula | 1159 | 12.58 | 38 | −17 | 18 |
Right postcentral gyrus (43) | — | 10.19 | 62 | −11 | 15 |
Right precentral gyrus (6) | — | 11.40 | 53 | −14 | 36 |
Superior temporal gyrus (22) | — | 6.94 | 65 | −32 | 6 |
Left inferior frontal gyrus (47) | 50 | −7.80 | −46 | 20 | 0 |
Right inferior frontal gyrus (47) | 48 | −8.10 | 28 | 22 | −6 |
Supplementary motor area (6) | 45 | 6.65 | 2 | −11 | 66 |
Paracentral lobule (5) | 24 | 7.48 | −2 | −38 | 60 |
Component 12 | |||||
Left inferior frontal gyrus (45) | 2455 | 14.48 | −52 | 22 | 12 |
Dorsomedial prefrontal (9) | — | 12.64 | −4 | 50 | 38 |
Left middle frontal gyrus (6) | — | 12.01 | −44 | 10 | 50 |
Left middle temporal gyrus (21) | 1382 | 14.31 | −64 | −29 | −4 |
Left superior temporal gyrus (39) | — | 12.48 | −54 | −62 | 26 |
Right middle frontal gyrus (9) | 408 | −10.33 | 40 | 40 | 30 |
Left precuneus (7) | 271 | 9.89 | −4 | −52 | 36 |
Right superior occipital gyrus (19) | 155 | −7.26 | 22 | −74 | 36 |
Right inferior frontal gyrus (45) | 136 | 9.46 | 50 | 28 | −4 |
Right middle temporal gyrus (21) | 133 | 7.48 | 50 | −62 | 24 |
Component 19 | |||||
Left inferior frontal gyrus (45) | 1151 | 12.48 | −46 | 16 | 2 |
Left middle frontal gyrus (9) | — | 7.12 | −32 | 50 | 32 |
Left insula | — | 10.81 | −40 | −10 | −2 |
Right inferior frontal gyrus (47) | 1033 | 11.81 | 40 | 20 | −4 |
Right insula | — | 9.07 | 40 | −12 | −4 |
Right supramarginal gyrus (40) | 622 | 11.16 | 58 | −44 | 30 |
Right middle temporal (22) | — | 7.88 | 46 | −46 | 8 |
Dorsal anterior cingulate cortex (32) | 552 | 9.33 | −2 | 22 | 42 |
Left superior frontal gyrus (9) | 58 | 7.11 | −32 | 50 | 32 |
Components thresholded at |t|>5 and minimum cluster size of 20 contiguous voxels.