Abstract
Growth factors play important roles in synapse formation. Mouse models of neuropsychiatric diseases suggest that defects in synaptogenic growth factors, their receptors, and signaling pathways can lead to disordered neural development and various behavioral phenotypes, including anxiety, memory problems, and social deficits. Genetic association studies in humans have found evidence for similar relationships between growth factor signaling pathways and neuropsychiatric phenotypes. Accumulating data suggest that dysfunction in neuronal circuitry, caused by defects in growth factor-mediated synapse formation, contributes to the susceptibility to multiple neuropsychiatric diseases, including epilepsy, autism, and disorders of thought and mood (e.g., schizophrenia and bipolar disorder, respectively). In this review, we will focus on how specific synaptogenic growth factors and their downstream signaling pathways might be involved in the development of neuropsychiatric diseases.
Keywords: synapse, synaptogenesis, growth factor, psychiatry, mental illness
Introduction
Neuropsychiatric diseases are increasingly recognized to have developmental origins. Some of these illnesses, such as autism and ADHD, must be diagnosed based on symptoms identified during early childhood (Association, 2013). Others, such as bipolar disorder and schizophrenia, are usually diagnosed in adulthood, but are recognized to have some manifestations in childhood as well (Martin and Smith, 2013; Schulz et al., 2014). Although these illnesses were initially studied in isolation from each other, there is increasing evidence that these clinically disparate diseases may have common genetic origins (Smoller and Finn, 2003; Lichtenstein et al., 2010; Sullivan et al., 2012; Cross-Disorder Group of the Psychiatric Genomics et al., 2013). To take this idea further, if these diseases begin early in development and have identifiable common genetic origins, it is possible, and perhaps even likely, that perturbations in some common developmental pathways may be involved in their pathogenesis.
One major set of signaling molecules that are important in neural development are synaptogenic growth factors. These growth factors, including brain-derived neurotrophic factor (BDNF), the fibroblast growth factor (FGF) family, Wnts, and insulin-like growth factors (IGFs), are important not only in cell fate specification and neurogenesis, but specifically in the formation and maintenance of synapses (Vicario-Abejon et al., 1998; Barros et al., 2009; Terauchi et al., 2010; Guillemot and Zimmer, 2011; Corvin et al., 2012; Rosso and Inestrosa, 2013). Appropriate partnering of pre- and postsynaptic neurons is critical for the establishment of individual neuronal circuits, which in turn is the fundamental basis of overall wiring of the functional brain. Problems in these synaptogenic signaling pathways, which could occur either due to mutations in individual growth factors or their receptors, or inappropriate conduction of those signals through intracellular signaling pathways, could lead to abnormal connections between neurons or aberrant neuronal circuitry (Figure 1).
Several lines of evidence suggest that synaptogenic growth factors are involved in the pathogenesis of neuropsychiatric diseases. First, it is known that many mouse models with mutations in synaptogenic growth factors or their receptors have behavioral abnormalities, which may be analogous to neuropsychiatric disease in humans. For example, mice lacking FGF7 are predisposed to epilepsy in a kindling protocol (Terauchi et al., 2010). Second, some humans with mutations in growth factors have observable behavioral and cognitive problems. For example, people with a valine to methionine substitution at position 66 (V66M) in the proBDNF polypeptide have impaired episodic memory and increased risk of mood disorders (Egan et al., 2003; Schumacher et al., 2005). Finally, there is growing evidence that maintenance of proper networks and synaptogenesis and plasticity are impaired in neuropsychiatric illnesses (Brennand et al., 2011; Uddin et al., 2013), and growth factors are known to have a major role in all of these processes.
We propose that the critical stage of interest for studying these illnesses is during synaptogenesis, as this is when neurons are wired together to form functional circuits. For our purposes, “synaptogenesis” includes synapse development, maturation, and maintenance, as these steps are all essential for a mature, functional synapse. It is important to note that synapse maturation and modulation occur throughout life, and are likely to contribute to variations in disease presentation as development progresses. For example, FGF2 has been hypothesized as an “on-line” modulator of mood and anxiety in adults (Turner et al., 2006). Synaptogenic growth factors are released from both the pre- and postsynaptic neurons to assist synaptogenesis (Figure 2). Other developmental processes, such as neurogenesis and programmed cell death are also important in brain development, and occur throughout life; their potential contributions to the pathogenesis of neuropsychiatric diseases have been reviewed elsewhere (Margolis et al., 1994; Mennerick and Zorumski, 2000; Gigante et al., 2011; Petrik et al., 2012).
There are many molecules that act as synaptogenic growth factors in the brain. The most well-studied of these is BDNF, which has been linked to multiple neuropsychiatric diseases including bipolar disorder, depression, and schizophrenia (Neves-Pereira et al., 2002, 2005; Schumacher et al., 2005). The FGFs are a large family of growth factors, which are important in many processes throughout development. FGFs have recently been shown to be important in the development of glutamatergic and GABAergic synapses (Flajolet et al., 2008; Stevens et al., 2010; Terauchi et al., 2010) and have been implicated in a wide number of neuropsychiatric diseases (Evans et al., 2004; Perez et al., 2009; Terwisscha Van Scheltinga et al., 2010; Yamanaka et al., 2011; Turner et al., 2012). Wnts and their receptors have been implicated in learning and memory (Tabatadze et al., 2012; Fortress et al., 2013), autism (Wassink et al., 2001), and some forms of epilepsy (Lako et al., 1998). Although the insulin-like growth factor (IGF) family of factors and receptors was previously recognized primarily for its importance in neurogenesis, development, and aging, this family is also now known to have roles in cortical plasticity (Tropea et al., 2006) and memory (Chen et al., 2011). Other families of growth factors have also been shown to be active in synaptogenesis and brain development, such as the TGFβ, GDNF, and EGF/neuregulin families (Mei and Xiong, 2008; Paratcha and Ledda, 2008; Williamson and Hiesinger, 2008; Van Kesteren et al., 2008; Krieglstein et al., 2011). The contributions of growth factors are summarized in Table 1.
Table 1.
Growth factors proposed to be involved in brain development are listed, along with available evidence for their involvement in neuropsychiatric disease. Evidence from animal models is listed in blue, evidence from studies in humans or tissue derived from humans is listed in orange. Abbreviations used: 3 '-UTR, 3 '-untranslated region; AD, Alzheimer disease; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BDNF, brain-derived neurotrophic factor; CA3, cornu ammonis area 3; CATSHL, camptodactyly, tall stature, scoliosis, and hearing loss; CNS, central nervous system; DG, dentate gyrus; EGF, epidermal growth factor; ES cell, embryonic stem cell; Fz, Frizzled receptor; GDNF, glial-derived neurotrophic factor; GH, growth hormone; GluR, AMPA glutamate receptor subunit; JNK, c-Jun N-terminal kinase; LTP, long-term potentiation; MDD, major depressive disorder; miR, microRNA; MMSE, mini-mental status exam; NGF, nerve growth factor; NRG, neuregulin; NT-3, neurotrophin-3; NT-4, neurotrophin-4; OCD, obsessive compulsive disorder; PD, Parkinson disease; PFC, prefrontal cortex; PTZ, pentylenetetrazol; RNAi, RNA interference; Ryk, atypical receptor tyrosine kinase; SADDAN, severe achondroplasia with developmental delay and acanthosis nigricans; SNP, single nucleotide polymorphism; TGF, transforming growth factor; vmPFC, ventromedial prefrontal cortex; WAGRO, wilms tumor, aniridia, genitourinary anomalies, mental retardation, and obesity syndrome.
Growth factor signaling between pre- and postsynaptic neurons ensures that proper connections between both individual neurons and brain regions are made. Here we describe how dysregulation of these systems may lead to neuropsychiatric disease. Since many of these synaptogenic growth factors promote intracellular signaling through common signal transduction pathways, it is possible that modulation of one or a few of these pathways could lead to significant improvement of clinical symptoms.
BDNF and the neurotrophin family of growth factors
The neurotrophin family of growth factors includes BDNF, pro-BDNF, NGF, NT-3, and NT-4. Neurotrophins bind to the Trk family of receptors, as well as the p75 receptor, to activate multiple intracellular signaling cascades. BDNF binds primarily to TrkB, NGF to TrkA, NT-3 to TrkC and TrkB, and NT-4 primarily to TrkB. All neurotrophins bind with relatively low affinity to the p75 receptor, and proBDNF binds only the p75 receptor. When neurotrophins bind to Trks, they support the survival and growth of neurons. Neurotrophins secreted from the postsynaptic cell promote the survival and health of the presynaptic neuron, and maintain a synapse between the two cells. One exception to this rule is the binding of proBDNF to p75, which is usually a pro-apoptotic signal to neurons (Teng et al., 2005). BDNF may also participate in postsynaptic organization (Johnson-Venkatesh and Umemori, 2010; Yoshii et al., 2011), but it is unclear whether this is independent of its presynaptic organizational activities.
BDNF signaling plays a major role in CNS synaptogenesis. It is involved in development of both excitatory and inhibitory synapses (Itami et al., 2000; Fiorentino et al., 2009), and is important for strengthening excitatory synapses through long-term potentiation, a form of cellular and network learning and memory (Minichiello, 2009). BDNF is released from neurons both constitutively and in an activity-dependent fashion (Farhadi et al., 2000; Zha et al., 2001; Egan et al., 2003), and its activity-dependent expression is important for the development and maintenance of cortical inhibitory synapses (Hong et al., 2008). Mice with a hypomorphic or null TrkB allele in hindbrain neurons demonstrate impaired climbing fiber pruning at the climbing fiber-Purkinje cell synapse (Johnson et al., 2007), suggesting that TrkB signaling is important for developmental synaptic pruning, possibly in an activity-dependent fashion. BDNF also plays a role in shaping dendritic morphology, which is an important aspect of synaptogenesis. Mice homozygous (knock-in) for the V66M BDNF mutation show decreased cortical spine density and diameter (Liu et al., 2012), as well as decreased hippocampal and cortical dendritic complexity (Chen et al., 2006b; Yu et al., 2009). BDNF is upregulated in mouse hippocampus under conditions of environmental enrichment (Hu et al., 2013), which is known to enhance dendritic arborization (Turner et al., 2003) and number of hippocampal synapses (Gogolla et al., 2009; Babic and Zinsmaier, 2011). BDNF may have differential effects depending on where its mRNA is translated in the cell; recent evidence shows that somatic BDNF is important for dendritic spine formation, whereas dendritic BDNF expression is important for spine head growth and spine pruning (Orefice et al., 2013). Other neurotrophins, including NT-3 and NT-4, have not been shown conclusively to be involved in synaptogenesis; these do have importance in neurogenesis and other aspects of CNS development (Table 1).
BDNF has been implicated in the pathogenesis of multiple neuropsychiatric diseases, including depression (Schumacher et al., 2005), schizophrenia (Zintzaras, 2007), and Rett syndrome, a severe developmental disorder with autistic features (Larimore et al., 2009; Zeev et al., 2009). The V66M mutation in BDNF impairs activity-dependent release of BDNF in hippocampal cultures and is associated with impaired episodic memory, both in patients with schizophrenia and people without neurologic or psychiatric illness (Egan et al., 2003). Interestingly, this mutation may be both a risk factor for depression (Schumacher et al., 2005) and a protective factor against bipolar disorder (Geller et al., 2004), although not all genetic studies in humans support these associations (Neves-Pereira et al., 2002). Data from post-mortem patient tissue supports changes in mRNA and protein levels of BDNF and TrkB in patients with mood and psychotic disorders (Issa et al., 2010; Thompson Ray et al., 2011; Tripp et al., 2012; Qi et al., 2013). Data from animal models with deficits in neurotrophin signaling support the links between BDNF signaling and behavior. Mice lacking TrkB in forebrain neurons show impaired spatial learning, delay in fear conditioning, and impaired hippocampal LTP (Minichiello et al., 1999), as well as behavioral rigidity when faced with changing environmental conditions (Vyssotski et al., 2002). Another group, using the same forebrain-specific TrkB knockout mice, observed increased behavioral hyperactivity and impulsivity (Zorner et al., 2003). Mice with reduced BDNF expression levels display increased alcohol consumption (Hensler et al., 2003; McGough et al., 2004). The same is observed in mice when trkB expression levels are reduced (Jeanblanc et al., 2006). Although it is unknown whether NT-4 functions specifically in synaptogenesis, NT-4 null mice have deficits in fear conditioning and hippocampal LTP (Xie et al., 2000), which may have implications for human anxiety and cognitive disorders.
Fibroblast growth factors and their receptors
The FGF family includes 22 FGF genes, which are clustered into groups based on phylogenetic similarity and receptor specificity (Umemori, 2009). Among them, there are 4 FGF homologous factors (originally called FGFs 11–14, now known as FHFs), which are solely intracellular signaling molecules and do not bind to FGF receptors (FGFRs). Other FGFs bind to FGFRs, of which there are 4 genes that can be alternatively spliced into multiple receptor subtypes (Umemori, 2009). FGF signaling is important in organogenesis and growth throughout development (Beenken and Mohammadi, 2009). In the CNS, FGFs have many functions, including neurogenesis, fate specification, and neuronal survival (Dono, 2003; Mason, 2007). FGFs also play roles in axon guidance and target recognition. For example, FGF8 has been shown to be an axon guidance molecule for trochlear nerve axons in a cultured rat midbrain explant model of neuronal pathfinding (Irving et al., 2002), and FGF2 gradients help retinal ganglion cell axons find their targets in the optic tectum in developing Xenopus (McFarlane et al., 1995). Although some FGFs act by an endocrine mechanism in the periphery, (such as FGF19, FGF21, and FGF23), FGFs that are active in the CNS are released by postsynaptic cells to stimulate presynaptic organization (Terauchi et al., 2010), and therefore act primarily by local mechanisms within the CNS.
Evidence is accumulating for the importance of FGFs in synaptogenesis. In cultured rat hippocampal neurons, addition of FGF2 to the culture medium generates an increase in excitatory synapses via a MAPK-dependent mechanism (Li et al., 2002). In cultured neurons, FGF7 and FGF22 function as presynaptic organizers (Umemori et al., 2004; Terauchi et al., 2010). FGF7-null mice have a deficit in hippocampal inhibitory synapse formation while FGF22-null mice are deficient in hippocampal excitatory synapses (Terauchi et al., 2010), consistent with the roles of FGF7 and FGF22 in presynaptic organization (Umemori et al., 2004). Other FGFs, including FGFs 4, 6, and 9 also promote synaptic vesicle clustering in cultured neurons (Umemori et al., 2004), but their roles in synaptogenesis in vivo are unknown.
The evidence linking FGFs and behavioral abnormalities is growing. FGF7-null are prone to develop epilepsy after kindling, while FGF22-null are resistant to seizure induction (Terauchi et al., 2010), providing a link between synaptogenic defects and a neurobehavioral phenotype. Mice overexpressing FGF21 primarily in the liver, which is known to function in metabolism and insulin sensitivity, also show dysregulation in circadian rhythms, which is a common feature of mood disorders (Bookout et al., 2013); it is unknown whether these mice have other behavioral abnormalities consistent with mood alterations. It is also unknown whether FGF21 plays a role in synaptogenesis, although it is known to cross the blood-brain barrier (Bookout et al., 2013). Mice globally lacking FGF17 have impaired social interactions, a key diagnostic feature of autism (Scearce-Levie et al., 2008). Interestingly, FGF17 was found to induce neurite branching in cultured neurons (Umemori et al., 2004), suggestive that abnormal connectivity between neurons may underlie these behavioral changes in FGF17-null mice. Peripheral administration of FGF2 to rats with endogenously high levels of anxiety was found to reduce anxiety-like behaviors (Perez et al., 2009), while lentiviral shRNA-mediated knockdown of FGF2 in rat hippocampus increased anxiety-like behaviors (Eren-Kocak et al., 2011). Although no studies of FGF expression in anxiety disorder patients have been published, the body of literature supports the idea that FGF2, if not other FGFs, is an important regulator of many emotional states. Alterations in FGF expression in humans have also been associated with depression (Evans et al., 2004), substance abuse (Turner et al., 2012), and schizophrenia (Terwisscha Van Scheltinga et al., 2010). Mutations in FGFR2 are causative for Pfeiffer Syndrome, some severe forms of which manifest intellectual disability (Priolo et al., 2000; Shotelersuk et al., 2002). There are multiple other examples of FGFs and FGFRs linked to neuropsychiatric disease, which are detailed in Table 1. Overall, the data underscore the importance of normal FGF signaling both for normal synapse formation and normal neuropsychiatric functioning.
Wnt signaling molecules and their receptors
Wnts are a family of 19 highly-conserved secreted signaling glycoproteins that play important roles in embryogenesis and fate specification in early development. When they bind to their receptors, the Frizzled proteins and LRP coreceptors, they can trigger several different types of intracellular signaling pathways. The best characterized intracellular signaling pathway is the Wnt/Frizzled/β-catenin/GSK3-β pathway, also known as the canonical pathway. Wnts 1, 2, 3a, 7a, and 7b generally signal through the canonical pathway. There are also several non-canonical pathways that have been identified which do not signal via β-catenin, the most well-studied of which are the planar cell polarity (PCP) and the Wnt/calcium pathways. Wnts 4a and 5a signal through the PCP pathway, which is involved in neuronal migration as well as cell polarity (Okerlund and Cheyette, 2011). The Wnt/calcium pathway is important for control of calcium release from the endoplasmic reticulum (ER) for calcium-dependent intracellular signals (De, 2011). There are also a number of other Wnt signaling pathways, but these are generally less well-understood (Niehrs, 2012). Although Frizzled and LRP are the most well-studied receptors for Wnts, Wnts are also known to bind to many other cell surface receptors, including Ryk, ROR2, and others (Niehrs, 2012).
Wnt signaling pathways have many roles in CNS synaptogenesis, and can both increase or decrease synapse formation depending on the Wnt pathways and cell types involved. The role of Wnts in non-mammalian and peripheral nervous system synaptogenesis has been reviewed extensively elsewhere (Park and Shen, 2012; Poon et al., 2013). Wnt7a is a retrograde signal derived from cerebellar granule cells to presynaptic mossy fiber terminals in the cerebellum (Hall et al., 2000). Wnt7a binds to Dvl1, a mouse homolog of Disheveled, and induces clustering of synapsin I and axon growth cone remodeling (Hall et al., 2000; Ahmad-Annuar et al., 2006). In mice globally lacking either Wnt7a or Dvl1, there are deficits in cerebellar synapse formation, while mice null for both Wnt7a and Dvl1 have an additional defect in neurotransmitter release at mossy fiber-granule cell synapses (Hall et al., 2000; Ahmad-Annuar et al., 2006). Wnt7a also has a role in synaptic differentiation in the hippocampus, particularly enhancing the number and strength of excitatory synapses (Davis et al., 2008; Ciani et al., 2011); this is also true for Wnt7b (Davis et al., 2008). Wnt5a has been shown to increase the formation of glutamatergic synapses and maturation of dendritic spines in cultured neurons via a calcium-dependent mechanism (Varela-Nallar et al., 2010). However, in a separate study, application of Wnt5a to neuronal cultures resulted in a decrease in glutamatergic synapses (Davis et al., 2008), suggesting that Wnt5a effects may be dependent on culture conditions or downstream signaling pathways (canonical vs. non-canonical). Taken together, the data demonstrate the importance of Wnt signaling in synaptogenesis in both pre- and postsynaptic compartments.
Although many knockout mouse models for Wnts have been developed, most do not survive embryogenesis (Uusitalo et al., 1999; Van Amerongen and Berns, 2006), and therefore cannot be assessed for behavioral phenotypes. However, there are mouse models where other mediators of Wnt signaling have been genetically manipulated, which implicate Wnt signaling in behavior. Mice null for Dvl1 have diminished social interactions, a core feature of autism, as well as abnormal prepulse inhibition, which is observed in both autism and schizophrenia (Lijam et al., 1997). These mice also have deficits in hippocampal dendritic branching and cerebellar synaptogenesis (Lijam et al., 1997; Rosso et al., 2005). Forebrain-specific reduction of expression of β-catenin, the putative downstream signaling molecule for Dvl1, generates subtle behavioral changes in the tail suspension test, a depression-like endophenotype (Gould et al., 2008). The lack of similar behavioral deficits between the forebrain-specific β-catenin knockout and Dvl1-null mice could be due to the fact that the β-catenin knockout was limited to the forebrain, whereas the synaptic changes noted in Dvl1-null mice are primarily noted in hippocampus and cerebellum, or may be attributable to the multiplicity of downstream effectors of Wnt signaling. Another way to modulate Wnt signaling is by overexpressing Axin, a scaffolding protein that negatively regulates Wnt signaling. When mice overexpressing Axin are trained in a fear-conditioning paradigm, they exhibit an increase in freezing to contextual conditioning as well as changes in cued fear conditioning, suggestive that alterations in Wnt signaling could increase anxiety-related behaviors (Kim et al., 2011).
Wnts have been implicated in multiple genetic studies of human neuropsychiatric disease. Some data suggest that mutations in Wnt2 are linked with forms of autism with severe language deficits (Wassink et al., 2001), although not all studies have confirmed this association (McCoy et al., 2002). Interestingly, the CHD8 gene has been identified in multiple genetic studies of autism and related neurodevelopmental disorders (Neale et al., 2012; O'Roak et al., 2012a,b; Talkowski et al., 2012). The CHD8 protein binds β-catenin and negatively regulates Wnt/β-catenin signaling (Nishiyama et al., 2012). Wnts also can activate the retinoid-related orphan receptor alpha, RORA, which has been implicated by GWAS in several neuropsychiatric diseases, including autism (Nguyen et al., 2010; Sarachana and Hu, 2013), bipolar disorder (Le-Niculescu et al., 2009; but see McGrath et al., 2009), depression (Terracciano et al., 2010; Utge et al., 2010), and PTSD (Logue et al., 2013). Additionally, both lithium and valproic acid, medications commonly used to treat neuropsychiatric diseases, are known to inhibit GSK3β, a downstream effector of the canonical Wnt signaling pathway (Lucas and Salinas, 1997; Hall et al., 2002), and lithium treatment in mice activates Wnt signaling in various regions of the brain including amygdala and hippocampus (O'Brien et al., 2004).
Insulin-like growth factors and their receptors
IGFs are peptide growth factors identified based on their similarity to the peptide hormone, insulin. The family consists of two growth factor ligands (IGF1 and IGF2), two receptors (IGF1R and IGF2R), and multiple IGF binding proteins (IGFBPs) and IGFBP-related proteins (Fernandez and Torres-Aleman, 2012). IGF1 is a neurotrophic factor that enhances the survival of neurons in culture (Meyer-Franke et al., 1995; Arnaldez and Helman, 2012; O'Kusky and Ye, 2012). IGF2 has also been implicated in neurogenesis, synaptogenesis, myelination, and dendritic branching (Agis-Balboa et al., 2011; Fernandez and Torres-Aleman, 2012; Schmeisser et al., 2012). The mechanism of IGF1 action on neurons may be both endocrine and autocrine, as it circulates in the bloodstream and can cross the blood-brain barrier, in addition to being secreted locally by neurons (Nunez et al., 2003) (Figure 2). IGF2 may also serve a neurotrophic function, at least for young hippocampal neurons, since increasing IGF2/IGFBP7 signaling via a fear-conditioning paradigm in mice leads to enhanced survival of newborn hippocampal neurons (Agis-Balboa et al., 2011).
The primary physiologic receptor for the IGFs is IGF1R, although IGF1 can also bind the insulin receptor. Like many growth factor receptors, IGF1R is a receptor tyrosine kinase, and when bound by IGF1, can activate several different intracellular cascades (Arnaldez and Helman, 2012). IGF2R can bind IGF2, but not IGF1. IGF2R is thought primarily to sequester IGF2 at the cell surface, and in most cases this binding does not generate transmembrane signals. IGFBPs regulate IGF activity by binding to IGFs and IGF1R, and this binding can inhibit or facilitate the binding of IGFs to IGF1R, or prolong the half-life of IGFs, depending upon the IGF/IGFBP pair and the specific microenvironment (O'Kusky and Ye, 2012).
IGF1 is widely expressed throughout the brain throughout development (Garcia-Segura et al., 1991), and IGF1 is upregulated in neurons during the developmental periods associated with dendritic maturation and synapse formation (Bondy, 1991). Application of IGF1 to cultured cortical neurons causes an increase in puncta containing PSD-95 and synapsin, but not puncta containing gephyrin, suggestive that IGF1 treatment increases the number of excitatory rather than inhibitory synapses in the cortex (Corvin et al., 2012). Interestingly, in mice modeling a severe form of autism, Rett syndrome, treatment with an active IGF1 peptide fragment partially restores spine density, synaptic function, PSD-95 localization and levels, and synaptic plasticity (Tropea et al., 2009). IGF2 is expressed in neurons and may localize to synaptic sites, and application of IGF2 to cultured hippocampal neurons causes an increase in spine formation via an IGF2R-dependent mechanism (Schmeisser et al., 2012), in contrast to previous data suggesting that IGF2R functions only as a reservoir to bind IGF2 at the cell surface. IGF1R is found in both pre- and postsynaptic areas in certain hypothalamic nuclei and the cerebellum (Garcia-Segura et al., 1997), suggestive that IGF signaling may play roles in both pre- and postsynaptic organization. IGF2R also localizes to postsynaptic densities (Schmeisser et al., 2012).
Animal models have demonstrated the importance of IGFs in normal synaptogenesis as well as neuropsychiatric disease. In rat pups, environmental enrichment during youth is also known to reduce anxiety-like behaviors during adulthood, but this effect of environmental enrichment is lost when IGF1 activity is blocked by systemic injection of blocking peptide during environmental enrichment. Interestingly, IGF1 injection during youth mimics the anxiolytic effects of environmental enrichment when the rats reach adulthood (Baldini et al., 2013). Blockade of IGF1 during youth, and the concomitant increase in anxiety-like behaviors in adulthood, is correlated with increased hippocampal IGF1R expression at postnatal day 12 in rats and increased glucocorticoid receptor expression at postnatal day 60 (Baldini et al., 2013). Interestingly, IGF1 infusion into the CSF of adult rats improved their performance on both cognitive and affective reactivity tasks (Markowska et al., 1998).
There are limited data from humans on the potential role of IGF signaling in neuropsychiatric disease, but there are some lines of evidence that implicate IGF signaling may be important. Lithium is one of the most effective treatments available for bipolar disorder, and it is known to inhibit GSK3β (Hedgepeth et al., 1997; Chalecka-Franaszek and Chuang, 1999). In patient-derived lymphoblastoid cell lines, bipolar disorder patients who respond to lithium have higher levels of IGF1 than bipolar disorder patients who do not respond to lithium (Squassina et al., 2013). This suggests that IGF1 may act upstream of GSK3β in modulating lithium response (Cui et al., 1998; Chalecka-Franaszek and Chuang, 1999). There is also significant evidence that insulin and IGF signaling promote the aging process in many animals (Bartke, 2008; Kenyon, 2010), raising the intriguing possibility that age-related cognitive decline may be mediated by the effects of insulin and IGFs on transcription factors and synapse function.
Synaptogenic growth factor signaling pathways
There is significant crossover in the intracellular downstream signaling pathways activated by synaptogenic growth factors. These pathways include (a) the MAPK/ERK pathway, (b) the PI3K/Akt pathway, and (c) the PLC/IP3/CAMK pathway. Significantly, all of these pathways have been implicated in several different neuropsychiatric diseases. We will address the evidence linking each individual pathway to synaptogenesis and disease, and then present a model that may help explain how these systems are linked in disease pathogenesis.
The MAPK/ERK pathway
The MAPK/ERK pathway is a common signal transduction pathway for many synaptogenic growth factors, including BDNF, FGFs, some Wnts, and IGF1 (Easton et al., 1999; Perron and Bixby, 1999; Quevedo et al., 2000; Bikkavilli et al., 2008). This signaling cascade begins when a synaptogenic growth factor binds its receptor, often itself a receptor tyrosine kinase except in the case of some Wnt receptors, and activates it. This results in binding of intracellular signaling proteins, which ultimately activate MAPK, which activates ERK. ERK can activate multiple transcription factors, including CREB, RSK, and myc. There are many ways in which alterations in this signaling pathway can contribute to neuropsychiatric disease. A mutation in RSK2, one of the downstream effector molecules of this pathway, can cause Coffin-Lowry syndrome, an X-linked form of severe intellectual disability (Morice et al., 2013). Mutations of the RSK2 gene in humans are associated with smaller volumes of hippocampus, cerebellum and temporal lobe, while a mouse model of Coffin-Lowry syndrome lacking Rsk2 demonstrates defects in hippocampal spine morphology and hippocampus-dependent learning (Morice et al., 2013). There is also evidence that environmental stressors can alter the MAPK/ERK pathway. In rhesus monkeys who were abused or neglected by their mothers during childhood, decreased CSF serotonin metabolites were correlated with both activated p38 MAPK in serum monocytes as well as increased risk of anxiety behaviors, delayed social development and reduced exploration as adolescents (McCormack et al., 2006; Sanchez et al., 2007).
The PI3K/Akt pathway
Another critical intracellular signaling pathway, the PI3K/Akt pathway, is activated when synaptogenic growth factor receptors phosphorylate PI3K. PI3K activation then leads to phosphorylation of Akt. Akt can translocate into the nucleus to regulate other transcription factors, leading to changes in levels of synaptic proteins, and can also activate mTOR (mammalian target of rapamycin) and thereby indirectly influence the growth and survival of cells. In neurons, the PI3K/Akt pathway is activated by growth factors including BDNF and IGF1 (Stroppolo et al., 2001; Bondy and Cheng, 2004; Li and Thiele, 2007). One study suggests that exogenous FGF1 may activate this pathway in astrocytes (Ito et al., 2013), although whether this is also the case for neurons is unknown. There is some evidence that this pathway can be activated by FGFR2 in oligodendrocytes independent of any FGF ligand at all (Bryant et al., 2009). This pathway is also activated by FGF7 in lung tissue (Ray et al., 2003), but it is not known whether FGF7 can also activate this pathway in neurons. Environmental enrichment, which is known to have multiple beneficial effects on anxiety-like behaviors in rodents, upregulates the Akt pathway and leads to downregulation of GSK3β (Hu et al., 2013). Akt itself has been implicated as a risk factor for schizophrenia susceptibility, as a specific AKT1 haplotype causes decreased Akt levels and is associated with illness (Emamian et al., 2004). Another Akt family member, AKT3, has been shown to be important in some cases of brain malformation and epilepsy (Poduri et al., 2012b), linking this pathway to multiple aspects of brain development, including circuit formation, circuit activity, and neuronal survival. Finally, the specific serotonin reuptake inhibitor, fluoxetine, increases phosphorylation of Akt as well as ERK in rat neural stem cells (Kitagishi et al., 2012; Huang et al., 2013). The fact that fluoxetine and other medications in its class are useful for a wide variety of neuropsychiatric illnesses outside of depression lends further support to the idea that these illnesses may have common origins.
The PLC/IP3/CAMK pathway
A third common signal transduction pathway activated by many synaptogenic growth factors and implicated in neuropsychiatric disease is the PLC/IP3/CAMK pathway. It is activated by BDNF, many FGFs, and some Wnts (Klint and Claesson-Welsh, 1999; Reichardt, 2006). It may be induced by IGF1, although it is unknown whether this is via direct IGFR1 activation of PLC or if this occurs indirectly (Chattopadhyay and Carpenter, 2002). In this pathway, activation of receptor tyrosine kinases by extracellular binding of synaptogenic growth factors leads to activation of phospholipase C (PLC, most commonly PLCγ1) and generation of the second messenger IP3. IP3 diffuses to the ER where it binds to its receptor, IP3R. IP3R is a calcium channel that releases calcium from the ER. When released into the cytosol, calcium can bind to a number of calcium-dependent proteins, such as calmodulin, which activates a number of important intracellular enzymes, including the calmodulin-dependent kinases (CAMKs). CAMKs are important effector molecules for a number of neuronal functions, including long-term potentiation (Sanhueza et al., 2007) and calcium-response element (CRE)-dependent transcription (Kang et al., 2001). One particular CAMK protein, Camk2B, is expressed widely in the CNS, and levels of CAMK2B mRNA were found to be upregulated 2-fold in the frontal cortex of post-mortem schizophrenia patient brains compared to control brains (Novak et al., 2000). In a single patient, a point mutation in CAMK2G (R29P) was associated with a number of phenotypic abnormalities, including severe intellectual disability (De Ligt et al., 2012). Mice lacking Camk4 have deficits in fear learning, with corresponding reductions in phosphorylated CREB in brain areas associated with fear memory after training (Wei et al., 2002). One of the upstream signaling factors in this pathway, PLCβ1, has been implicated in severe forms of epilepsy (Kurian et al., 2010; Poduri et al., 2012a). All of these lines of evidence point to the importance of this pathway in normal neural development and function, and there is clear evidence of synaptic dysfunction and behavioral phenotypes when these pathways are altered.
Crosstalk between signaling pathways
Most synaptogenic growth factors can activate multiple downstream signaling pathways depending on which receptor they bind, and in which cell type the receptor is expressed. Due to the fact that activated growth factor receptors can bind promiscuously to various intracellular second messengers, it is unlikely that any single growth factor signaling cascade will account for all of the phenotypes observed in a given neuropsychiatric disease. It is far more likely that the complex interplay of a number of signaling pathways will generate an observable phenotype, such as autism or depression. However, all three pathways described above have intermediary signaling molecules (ERK, Akt, and CaMKII) that can activate cAMP/calcium-response element binding protein (CREB) and lead to CRE-dependent transcription of genes (Figure 3). CREB-mediated transcription is critical for expression of a number of genes, including some synaptogenic growth factors as well as c-fos and other activity-dependent genes (Benito and Barco, 2010). CREB may serve as a key integrator of signals of neuronal activity, such as NMDA receptor activation-mediated calcium influx, with synaptogenic growth factor signaling (such as the cascades described above). Activation of CREB then leads to transcription of activity-dependent genes that play roles in synaptogenesis. One such activity-dependent gene is the L-type voltage-gated calcium channel (VGCC), which has recently been the focus of much interest as SNPs within the alpha subunit of one L-type VGCC has been implicated as a risk factor in multiple neuropsychiatric diseases (Andreassen et al., 2013; Cross-Disorder Group of the Psychiatric Genomics et al., 2013).
Another possible cellular focus for synaptogenic growth factor signal integration is the WAVE regulatory complex (WRC), a large five-subunit complex that controls actin cytoskeleton dynamics (Pollitt and Insall, 2009). Recently, two papers were published which describe how cell surface receptors containing a WRC interacting receptor sequence (WIRS) domain interact with the WRC and the actin cytoskeleton to direct synapse formation and changes in neuronal morphology including axonal branching (Chen et al., 2014; Chia et al., 2014). Many synaptic proteins have potential WIRS domains, including some synaptogenic growth factor receptors (Chen et al., 2014). The WAVE complex might be another major intergrator of synaptogenic growth factor signaling in neurons.
Crosstalk between multiple growth factor pathways occurs as well, further underlining how interconnected these systems are in the brain. For example, Wnt signaling triggers transcription of FGF4 in tooth development (Kratochwil et al., 2002), sequential signaling by Wnt3a and FGF8 are required to induce dorsalization during brain development (Gunhaga et al., 2003), and both FGF19 and Wnt8C signaling are required for successful inner ear development (Ladher et al., 2000). Cooperative signaling of the Wnt and FGF systems is also critical in spinal cord specification (Nordstrom et al., 2006). Recently, crosstalk between FGF and Wnt signaling in C. elegans sensory organs was described on a transcriptional level, where FGF activates the MAPK/ERK pathway and regulates a downstream Wnt effector molecule (Squarzoni et al., 2011). Therefore, it will be important to consider that modulation of a single synaptogenic growth factor or intracellular signaling pathway will likely affect other systems as well.
Conclusions and future directions
Growth factor signaling between pre- and postsynaptic neurons is critical for proper connections between individual neurons, and for the development of appropriate brain circuitry. Synaptogenic growth factors play a key role in ensuring that synapses develop properly and are modulated appropriately over time, so that suitable emotional and behavioral responses to the environment are generated when necessary. As described, dysregulation of these systems may lead to inappropriate emotional and behavioral responses to either internal or external stimuli, which is associated with functional decline. Modulation of synapses over time is also critical for learning and memory when the environment changes, and dysfunction in these processes likely contributes to cognitive impairment. Ongoing synaptogenic dysregulation caused by defects in growth factor signaling may cause these illnesses not to improve (as in autism) or worsen and become increasingly difficult to treat (such as schizophrenia) over a patient's lifetime. Complicating this picture is the possibility that the specific functions of growth factors may change throughout development. Conversely, at different times throughout the life cycle, different growth factors may be required for similar functions. For example, at the neuromuscular junction (NMJ), laminin-β2 is a critical presynaptic organizer in the neonate, whereas collagen IV performs this function in the adult (Nishimune et al., 2004; Fox et al., 2007). Therefore, it is possible that the mutations or abnormalities in growth factors may only be relevant at specific developmental times, or in different locations, for specific neuropsychiatric diseases. Additionally, many other genetic risk factors for neuropsychiatric diseases are associated with synapse-specific proteins, including the synaptic scaffolding Shank proteins (Guilmatre et al., 2014), the synaptic adhesion molecules contactin/caspr and neurexin/neuroligin (Sudhof, 2008; Vernes et al., 2008; Kenny et al., 2013; Zuko et al., 2013), and proteins in the mTOR pathway, which is critical for synapse-specific protein synthesis (Hoeffer and Klann, 2010; Russo et al., 2012; Wong, 2013). These molecules and pathways may interact with the growth factor pathways (Patzke and Ernsberger, 2000; Iki et al., 2005; Hoeffer and Klann, 2010; Williams and Casanova, 2011; Russo et al., 2012; Wong, 2013; Bennett and Lagopoulos, 2014). The myriad ways in which these pathways may be linked requires further exploration.
Nevertheless, since many receptors for synaptogenic growth factors act through common intracellular signal transduction pathways, it may be that modulation of one or a few of these pathways could lead to significant resolution of clinical symptoms. In addition, growth factor binding proteins often act as regulators of growth factor binding and localization, which have the added benefit of functioning in the extracellular space rather than intracellular compartments. This could significantly reduce the difficulty of getting treatments to their target sites. Additionally, in the case of FGFs, heparan sulfate proteoglycans (HSPGs) are required for binding of FGFs to their receptors at high affinity (Klint and Claesson-Welsh, 1999). Modulation of certain HSPGs could alter FGF binding to particular FGFRs. Such an approach may also be possible with other synaptogenic growth factors.
Conflict of interest statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
- Ades L. C., Sullivan K., Biggin A., Haan E. A., Brett M., Holman K. J., et al. (2006). FBN1, TGFBR1, and the Marfan-craniosynostosis/mental retardation disorders revisited. Am. J. Med. Genet. A 140, 1047–1058 10.1002/ajmg.a.31202 [DOI] [PubMed] [Google Scholar]
- Agis-Balboa R. C., Arcos-Diaz D., Wittnam J., Govindarajan N., Blom K., Burkhardt S., et al. (2011). A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories. EMBO J. 30, 4071–4083 10.1038/emboj.2011.293 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ahmad-Annuar A., Ciani L., Simeonidis I., Herreros J., Fredj N. B., Rosso S. B., et al. (2006). Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release. J. Cell Biol. 174, 127–139 10.1083/jcb.200511054 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Aliashkevich A. F., Yilmazer-Hanke D., Van Roost D., Mundhenk B., Schramm J., Blumcke I. (2003). Cellular pathology of amygdala neurons in human temporal lobe epilepsy. Acta Neuropathol. 106, 99–106 10.1007/s00401-003-0707-0 [DOI] [PubMed] [Google Scholar]
- Alsmadi O., Meyer B. F., Alkuraya F., Wakil S., Alkayal F., Al-Saud H., et al. (2009). Syndromic congenital sensorineural deafness, microtia and microdontia resulting from a novel homoallelic mutation in fibroblast growth factor 3 (FGF3). Eur. J. Hum. Genet. 17, 14–21 10.1038/ejhg.2008.141 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Andreassen O. A., Djurovic S., Thompson W. K., Schork A. J., Kendler K. S., O'donovan M. C., et al. (2013). Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. Am. J. Hum. Genet. 92, 197–209 10.1016/j.ajhg.2013.01.001 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Arauz R. F., Solomon B. D., Pineda-Alvarez D. E., Gropman A. L., Parsons J. A., Roessler E., et al. (2010). A hypomorphic allele in the FGF8 gene contributes to holoprosencephaly and is allelic to gonadotropin-releasing hormone deficiency in humans. Mol. Syndromol. 1, 59–66 10.1159/000302285 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Arnaldez F. I., Helman L. J. (2012). Targeting the insulin growth factor receptor 1. Hematol. Oncol. Clin. North Am. 26, 527–542, vii–viii. 10.1016/j.hoc.2012.01.004 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Association A. P. (2013). Diagnostic and Statistical Manual of Mental Disorders, 5th Edn. Arlington, VA: American Psychiatric Publishing [Google Scholar]
- Babic M., Zinsmaier K. E. (2011). Memory, synapse stability, and beta-adducin. Neuron 69, 1039–1041 10.1016/j.neuron.2011.03.004 [DOI] [PubMed] [Google Scholar]
- Baldini S., Restani L., Baroncelli L., Coltelli M., Franco R., Cenni M. C., et al. (2013). Enriched early life experiences reduce adult anxiety-like behavior in rats: a role for insulin-like growth factor 1. J. Neurosci. 33, 11715–11723 10.1523/JNEUROSCI.3541-12.2013 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barros C. S., Calabrese B., Chamero P., Roberts A. J., Korzus E., Lloyd K., et al. (2009). Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 106, 4507–4512 10.1073/pnas.0900355106 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bartke A. (2008). Insulin and aging. Cell Cycle 7, 3338–3343 10.4161/cc.7.21.7012 [DOI] [PubMed] [Google Scholar]
- Beenken A., Mohammadi M. (2009). The FGF family: biology, pathophysiology and therapy. Nat. Rev. Drug Discov. 8, 235–253 10.1038/nrd2792 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bendall S. C., Stewart M. H., Menendez P., George D., Vijayaragavan K., Werbowetski-Ogilvie T., et al. (2007). IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro. Nature 448, 1015–1021 10.1038/nature06027 [DOI] [PubMed] [Google Scholar]
- Benito E., Barco A. (2010). CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models. Trends Neurosci. 33, 230–240 10.1016/j.tins.2010.02.001 [DOI] [PubMed] [Google Scholar]
- Bennett M. R., Lagopoulos J. (2014). Stress and trauma: BDNF control of dendritic-spine formation and regression. Prog. Neurobiol. 112, 80–99 10.1016/j.pneurobio.2013.10.005 [DOI] [PubMed] [Google Scholar]
- Bikkavilli R. K., Feigin M. E., Malbon C. C. (2008). p38 mitogen-activated protein kinase regulates canonical Wnt-beta-catenin signaling by inactivation of GSK3beta. J. Cell Sci. 121, 3598–3607 10.1242/jcs.032854 [DOI] [PubMed] [Google Scholar]
- Blakely B. D., Bye C. R., Fernando C. V., Prasad A. A., Pasterkamp R. J., Macheda M. L., et al. (2013). Ryk, a receptor regulating Wnt5a-mediated neurogenesis and axon morphogenesis of ventral midbrain dopaminergic neurons. Stem Cells Dev. 22, 2132–2144 10.1089/scd.2013.0066 [DOI] [PubMed] [Google Scholar]
- Bondy C. A. (1991). Transient IGF-I gene expression during the maturation of functionally related central projection neurons. J. Neurosci. 11, 3442–3455 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bondy C. A., Cheng C. M. (2004). Signaling by insulin-like growth factor 1 in brain. Eur. J. Pharmacol. 490, 25–31 10.1016/j.ejphar.2004.02.042 [DOI] [PubMed] [Google Scholar]
- Bookout A. L., De Groot M. H., Owen B. M., Lee S., Gautron L., Lawrence H. L., et al. (2013). FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Nat. Med. 19, 1147–1152 10.1038/nm.3249 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Boucher T. J., Okuse K., Bennett D. L., Munson J. B., Wood J. N., McMahon S. B. (2000). Potent analgesic effects of GDNF in neuropathic pain states. Science 290, 124–127 10.1126/science.290.5489.124 [DOI] [PubMed] [Google Scholar]
- Brennand K. J., Simone A., Jou J., Gelboin-Burkhart C., Tran N., Sangar S., et al. (2011). Modelling schizophrenia using human induced pluripotent stem cells. Nature 473, 221–225 10.1038/nature09915 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brionne T. C., Tesseur I., Masliah E., Wyss-Coray T. (2003). Loss of TGF-beta 1 leads to increased neuronal cell death and microgliosis in mouse brain. Neuron 40, 1133–1145 10.1016/S0896-6273(03)00766-9 [DOI] [PubMed] [Google Scholar]
- Bryant M. R., Marta C. B., Kim F. S., Bansal R. (2009). Phosphorylation and lipid raft association of fibroblast growth factor receptor-2 in oligodendrocytes. Glia 57, 935–946 10.1002/glia.20818 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bulow B., Hagmar L., Orbaek P., Osterberg K., Erfurth E. M. (2002). High incidence of mental disorders, reduced mental well-being and cognitive function in hypopituitary women with GH deficiency treated for pituitary disease. Clin. Endocrinol. (Oxf.) 56, 183–193 10.1046/j.0300-0664.2001.01461.x [DOI] [PubMed] [Google Scholar]
- Cao L., Jiao X., Zuzga D. S., Liu Y., Fong D. M., Young D., et al. (2004). VEGF links hippocampal activity with neurogenesis, learning and memory. Nat. Genet. 36, 827–835 10.1038/ng1395 [DOI] [PubMed] [Google Scholar]
- Carnicella S., Kharazia V., Jeanblanc J., Janak P. H., Ron D. (2008). GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse. Proc. Natl. Acad. Sci. U.S.A. 105, 8114–8119 10.1073/pnas.0711755105 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carvalho O. P., Thornton G. K., Hertecant J., Houlden H., Nicholas A. K., Cox J. J., et al. (2011). A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy. J. Med. Genet. 48, 131–135 10.1136/jmg.2010.081455 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chalecka-Franaszek E., Chuang D. M. (1999). Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. Proc. Natl. Acad. Sci. U.S.A. 96, 8745–8750 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chattopadhyay A., Carpenter G. (2002). PLC-gamma1 is required for IGF-I protection from cell death induced by loss of extracellular matrix adhesion. J. Cell Sci. 115, 2233–2239 [DOI] [PubMed] [Google Scholar]
- Chen B., Brinkmann K., Chen Z., Pak C. W., Liao Y., Shi S., et al. (2014). The WAVE regulatory complex links diverse receptors to the actin cytoskeleton. Cell 156, 195–207 10.1016/j.cell.2013.11.048 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chen D. Y., Stern S. A., Garcia-Osta A., Saunier-Rebori B., Pollonini G., Bambah-Mukku D., et al. (2011). A critical role for IGF-II in memory consolidation and enhancement. Nature 469, 491–497 10.1038/nature09667 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chen J., Park C. S., Tang S. J. (2006a). Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation. J. Biol. Chem. 281, 11910–11916 10.1074/jbc.M511920200 [DOI] [PubMed] [Google Scholar]
- Chen Z. Y., Jing D., Bath K. G., Ieraci A., Khan T., Siao C. J., et al. (2006b). Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314, 140–143 10.1126/science.1129663 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chia P. H., Chen B., Li P., Rosen M. K., Shen K. (2014). Local F-actin network links synapse formation and axon branching. Cell 156, 208–220 10.1016/j.cell.2013.12.009 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cholfin J. A., Rubenstein J. L. (2007). Patterning of frontal cortex subdivisions by Fgf17. Proc. Natl. Acad. Sci. U.S.A. 104, 7652–7657 10.1073/pnas.0702225104 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chung K., Wallace J., Kim S. Y., Kalyanasundaram S., Andalman A. S., Davidson T. J., et al. (2013). Structural and molecular interrogation of intact biological systems. Nature 497, 332–337 10.1038/nature12107 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ciani L., Boyle K. A., Dickins E., Sahores M., Anane D., Lopes D. M., et al. (2011). Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca(2)(+)/Calmodulin-dependent protein kinase II. Proc. Natl. Acad. Sci. U.S.A. 108, 10732–10737 10.1073/pnas.1018132108 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Clarimon J., Xiromerisiou G., Eerola J., Gourbali V., Hellstrom O., Dardiotis E., et al. (2005). Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients. BMC Neurol. 5:11 10.1186/1471-2377-5-11 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Colvin J. S., Bohne B. A., Harding G. W., McEwen D. G., Ornitz D. M. (1996). Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nat. Genet. 12, 390–397 10.1038/ng0496-390 [DOI] [PubMed] [Google Scholar]
- Corvin A. P., Molinos I., Little G., Donohoe G., Gill M., Morris D. W., et al. (2012). Insulin-like growth factor 1 (IGF1) and its active peptide (1-3)IGF1 enhance the expression of synaptic markers in neuronal circuits through different cellular mechanisms. Neurosci. Lett. 520, 51–56 10.1016/j.neulet.2012.05.029 [DOI] [PubMed] [Google Scholar]
- Cosgaya J. M., Chan J. R., Shooter E. M. (2002). The neurotrophin receptor p75NTR as a positive modulator of myelination. Science 298, 1245–1248 10.1126/science.1076595 [DOI] [PubMed] [Google Scholar]
- Counts S. E., Nadeem M., Wuu J., Ginsberg S. D., Saragovi H. U., Mufson E. J. (2004). Reduction of cortical TrkA but not p75(NTR) protein in early-stage Alzheimer's disease. Ann. Neurol. 56, 520–531 10.1002/ana.20233 [DOI] [PubMed] [Google Scholar]
- Cross-Disorder Group of the Psychiatric. Genomics C., Smoller J. W., Craddock N., Kendler K., Lee P. H., Neale B. M., et al. (2013). Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 381, 1371–1379 10.1016/S0140-6736(12)62129-1 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cui H., Meng Y., Bulleit R. F. (1998). Inhibition of glycogen synthase kinase 3beta activity regulates proliferation of cultured cerebellar granule cells. Brain Res. Dev. Brain Res. 111, 177–188 [DOI] [PubMed] [Google Scholar]
- Davis E. K., Zou Y., Ghosh A. (2008). Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation. Neural Dev. 3, 32 10.1186/1749-8104-3-32 [DOI] [PMC free article] [PubMed] [Google Scholar]
- De A. (2011). Wnt/Ca2+ signaling pathway: a brief overview. Acta Biochim. Biophys. Sin. (Shanghai). 43, 745–756 10.1093/abbs/gmr079 [DOI] [PubMed] [Google Scholar]
- De Ligt J., Willemsen M. H., Van Bon B. W., Kleefstra T., Yntema H. G., Kroes T., et al. (2012). Diagnostic exome sequencing in persons with severe intellectual disability. N. Engl. J. Med. 367, 1921–1929 10.1056/NEJMoa1206524 [DOI] [PubMed] [Google Scholar]
- Dode C., Levilliers J., Dupont J. M., De Paepe A., Le Du N., Soussi-Yanicostas N., et al. (2003). Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome. Nat. Genet. 33, 463–465 10.1038/ng1122 [DOI] [PubMed] [Google Scholar]
- Doniach T. (1995). Basic FGF as an inducer of anteroposterior neural pattern. Cell 83, 1067–1070 [DOI] [PubMed] [Google Scholar]
- Dono R. (2003). Fibroblast growth factors as regulators of central nervous system development and function. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284, R867–R881 10.1152/ajpregu.00533.2002 [DOI] [PubMed] [Google Scholar]
- Dono R., Texido G., Dussel R., Ehmke H., Zeller R. (1998). Impaired cerebral cortex development and blood pressure regulation in FGF-2-deficient mice. EMBO J. 17, 4213–4225 10.1093/emboj/17.15.4213 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Easton J. B., Moody N. M., Zhu X., Middlemas D. S. (1999). Brain-derived neurotrophic factor induces phosphorylation of fibroblast growth factor receptor substrate 2. J. Biol. Chem. 274, 11321–11327 [DOI] [PubMed] [Google Scholar]
- Egan M. F., Kojima M., Callicott J. H., Goldberg T. E., Kolachana B. S., Bertolino A., et al. (2003). The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112, 257–269 10.1016/S0092-8674(03)00035-7 [DOI] [PubMed] [Google Scholar]
- Emamian E. S., Hall D., Birnbaum M. J., Karayiorgou M., Gogos J. A. (2004). Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat. Genet. 36, 131–137 10.1038/ng1296 [DOI] [PubMed] [Google Scholar]
- Eren-Kocak E., Turner C. A., Watson S. J., Akil H. (2011). Short-hairpin RNA silencing of endogenous fibroblast growth factor 2 in rat hippocampus increases anxiety behavior. Biol. Psychiatry 69, 534–540 10.1016/j.biopsych.2010.11.020 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Evans S. J., Choudary P. V., Neal C. R., Li J. Z., Vawter M. P., Tomita H., et al. (2004). Dysregulation of the fibroblast growth factor system in major depression. Proc. Natl. Acad. Sci. U.S.A. 101, 15506–15511 10.1073/pnas.0406788101 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fagan A. M., Garber M., Barbacid M., Silos-Santiago I., Holtzman D. M. (1997). A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo. J. Neurosci. 17, 7644–7654 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Falardeau J., Chung W. C., Beenken A., Raivio T., Plummer L., Sidis Y., et al. (2008). Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice. J. Clin. Invest. 118, 2822–2831 10.1172/JCI34538 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Farhadi H. F., Mowla S. J., Petrecca K., Morris S. J., Seidah N. G., Murphy R. A. (2000). Neurotrophin-3 sorts to the constitutive secretory pathway of hippocampal neurons and is diverted to the regulated secretory pathway by coexpression with brain-derived neurotrophic factor. J. Neurosci. 20, 4059–4068 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fernandez A. M., Torres-Aleman I. (2012). The many faces of insulin-like peptide signalling in the brain. Nat. Rev. Neurosci. 13, 225–239 10.1038/nrn3209 [DOI] [PubMed] [Google Scholar]
- Fiorentino H., Kuczewski N., Diabira D., Ferrand N., Pangalos M. N., Porcher C., et al. (2009). GABA(B) receptor activation triggers BDNF release and promotes the maturation of GABAergic synapses. J. Neurosci. 29, 11650–11661 10.1523/JNEUROSCI.3587-09.2009 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Flajolet M., Wang Z., Futter M., Shen W., Nuangchamnong N., Bendor J., et al. (2008). FGF acts as a co-transmitter through adenosine A(2A) receptor to regulate synaptic plasticity. Nat. Neurosci. 11, 1402–1409 10.1038/nn.2216 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fortress A. M., Schram S. L., Tuscher J. J., Frick K. M. (2013). Canonical Wnt signaling is necessary for object recognition memory consolidation. J. Neurosci. 33, 12619–12626 10.1523/JNEUROSCI.0659-13.2013 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fox M. A., Sanes J. R., Borza D. B., Eswarakumar V. P., Fassler R., Hudson B. G., et al. (2007). Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals. Cell 129, 179–193 10.1016/j.cell.2007.02.035 [DOI] [PubMed] [Google Scholar]
- Francomano C. A., McIntosh I., Wilkin D. J. (1996). Bone dysplasias in man: molecular insights. Curr. Opin. Genet. Dev. 6, 301–308 [DOI] [PubMed] [Google Scholar]
- Frenz D. A., Liu W., Cvekl A., Xie Q., Wassef L., Quadro L., et al. (2010). Retinoid signaling in inner ear development: a “Goldilocks” phenomenon. Am. J. Med. Genet. A 152A, 2947–2961 10.1002/ajmg.a.33670 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fukuchi-Shimogori T., Grove E. A. (2001). Neocortex patterning by the secreted signaling molecule FGF8. Science 294, 1071–1074 10.1126/science.1064252 [DOI] [PubMed] [Google Scholar]
- Garcia-Segura L. M., Perez J., Pons S., Rejas M. T., Torres-Aleman I. (1991). Localization of insulin-like growth factor I (IGF-I)-like immunoreactivity in the developing and adult rat brain. Brain Res. 560, 167–174 [DOI] [PubMed] [Google Scholar]
- Garcia-Segura L. M., Rodriguez J. R., Torres-Aleman I. (1997). Localization of the insulin-like growth factor I receptor in the cerebellum and hypothalamus of adult rats: an electron microscopic study. J. Neurocytol. 26, 479–490 [DOI] [PubMed] [Google Scholar]
- Garcia-Vargas A., Hafner C., Perez-Rodriguez A. G., Rodriguez-Rojas L. X., Gonzalez-Esqueda P., Stoehr R., et al. (2008). An epidermal nevus syndrome with cerebral involvement caused by a mosaic FGFR3 mutation. Am. J. Med. Genet. A 146A, 2275–2279 10.1002/ajmg.a.32429 [DOI] [PubMed] [Google Scholar]
- Geller B., Badner J. A., Tillman R., Christian S. L., Bolhofner K., Cook E. H., Jr. (2004). Linkage disequilibrium of the brain-derived neurotrophic factor Val66Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype. Am. J. Psychiatry 161, 1698–1700 10.1176/appi.ajp.161.9.1698 [DOI] [PubMed] [Google Scholar]
- Gigante A. D., Young L. T., Yatham L. N., Andreazza A. C., Nery F. G., Grinberg L. T., et al. (2011). Morphometric post-mortem studies in bipolar disorder: possible association with oxidative stress and apoptosis. Int. J. Neuropsychopharmacol. 14, 1075–1089 10.1017/S146114571000146X [DOI] [PubMed] [Google Scholar]
- Gogolla N., Galimberti I., Deguchi Y., Caroni P. (2009). Wnt signaling mediates experience-related regulation of synapse numbers and mossy fiber connectivities in the adult hippocampus. Neuron 62, 510–525 10.1016/j.neuron.2009.04.022 [DOI] [PubMed] [Google Scholar]
- Gould T. D., O'donnell K. C., Picchini A. M., Dow E. R., Chen G., Manji H. K. (2008). Generation and behavioral characterization of beta-catenin forebrain-specific conditional knock-out mice. Behav. Brain Res. 189, 117–125 10.1016/j.bbr.2007.12.028 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gripp K. W., Stolle C. A., McDonald-McGinn D. M., Markowitz R. I., Bartlett S. P., Katowitz J. A., et al. (1998). Phenotype of the fibroblast growth factor receptor 2 Ser351Cys mutation: Pfeiffer syndrome type III. Am. J. Med. Genet. 78, 356–360 [DOI] [PubMed] [Google Scholar]
- Guillemot F., Zimmer C. (2011). From cradle to grave: the multiple roles of fibroblast growth factors in neural development. Neuron 71, 574–588 10.1016/j.neuron.2011.08.002 [DOI] [PubMed] [Google Scholar]
- Guilmatre A., Huguet G., Delorme R., Bourgeron T. (2014). The emerging role of SHANK genes in neuropsychiatric disorders. Dev. Neurobiol. 74, 113–122 10.1002/dneu.22128 [DOI] [PubMed] [Google Scholar]
- Gunhaga L., Marklund M., Sjodal M., Hsieh J. C., Jessell T. M., Edlund T. (2003). Specification of dorsal telencephalic character by sequential Wnt and FGF signaling. Nat. Neurosci. 6, 701–707 10.1038/nn1068 [DOI] [PubMed] [Google Scholar]
- Hall A. C., Brennan A., Goold R. G., Cleverley K., Lucas F. R., Gordon-Weeks P. R., et al. (2002). Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neurons. Mol. Cell. Neurosci. 20, 257–270 10.1006/mcne.2002.1117 [DOI] [PubMed] [Google Scholar]
- Hall A. C., Lucas F. R., Salinas P. C. (2000). Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling. Cell 100, 525–535 10.1016/S0092-8674(00)80689-3 [DOI] [PubMed] [Google Scholar]
- Hall D., Dhilla A., Charalambous A., Gogos J. A., Karayiorgou M. (2003). Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. Am. J. Hum. Genet. 73, 370–376 10.1086/377003 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Han J. C., Liu Q. R., Jones M., Levinn R. L., Menzie C. M., Jefferson-George K. S., et al. (2008). Brain-derived neurotrophic factor and obesity in the WAGR syndrome. N. Engl. J. Med. 359, 918–927 10.1056/NEJMoa0801119 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hedgepeth C. M., Conrad L. J., Zhang J., Huang H. C., Lee V. M., Klein P. S. (1997). Activation of the Wnt signaling pathway: a molecular mechanism for lithium action. Dev. Biol. 185, 82–91 10.1006/dbio.1997.8552 [DOI] [PubMed] [Google Scholar]
- Hensler J. G., Ladenheim E. E., Lyons W. E. (2003). Ethanol consumption and serotonin-1A (5-HT1A) receptor function in heterozygous BDNF (+/-) mice. J. Neurochem. 85, 1139–1147 10.1046/j.1471-4159.2003.01748.x [DOI] [PubMed] [Google Scholar]
- Hoeffer C. A., Klann E. (2010). mTOR signaling: at the crossroads of plasticity, memory and disease. Trends Neurosci. 33, 67–75 10.1016/j.tins.2009.11.003 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hollway G. E., Suthers G. K., Battese K. M., Turner A. M., David D. J., Mulley J. C. (1998). Deafness due to Pro250Arg mutation of FGFR3. Lancet 351, 877–878 10.1016/S0140-6736(98)24012-8 [DOI] [PubMed] [Google Scholar]
- Hong E. J., McCord A. E., Greenberg M. E. (2008). A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition. Neuron 60, 610–624 10.1016/j.neuron.2008.09.024 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Houart C., Caneparo L., Heisenberg C., Barth K., Take-Uchi M., Wilson S. (2002). Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. Neuron 35, 255–265 10.1016/S0896-6273(02)00751-1 [DOI] [PubMed] [Google Scholar]
- Hu Y. S., Long N., Pigino G., Brady S. T., Lazarov O. (2013). Molecular mechanisms of environmental enrichment: impairments in Akt/GSK3beta, neurotrophin-3 and CREB signaling. PLoS ONE 8:e64460 10.1371/journal.pone.0064460 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Huang W., Zhao Y., Zhu X., Cai Z., Wang S., Yao S., et al. (2013). Fluoxetine upregulates phosphorylated-AKT and phosphorylated-ERK1/2 proteins in neural stem cells: evidence for a crosstalk between AKT and ERK1/2 pathways. J. Mol. Neurosci. 49, 244–249 10.1007/s12031-012-9822-5 [DOI] [PubMed] [Google Scholar]
- Iki J., Inoue A., Bito H., Okabe S. (2005). Bi-directional regulation of postsynaptic cortactin distribution by BDNF and NMDA receptor activity. Eur. J. Neurosci. 22, 2985–2994 10.1111/j.1460-9568.2005.04510.x [DOI] [PubMed] [Google Scholar]
- Irving C., Malhas A., Guthrie S., Mason I. (2002). Establishing the trochlear motor axon trajectory: role of the isthmic organiser and Fgf8. Development 129, 5389–5398 10.1242/dev.00117 [DOI] [PubMed] [Google Scholar]
- Issa G., Wilson C., Terry A. V., Jr., Pillai A. (2010). An inverse relationship between cortisol and BDNF levels in schizophrenia: data from human postmortem and animal studies. Neurobiol. Dis. 39, 327–333 10.1016/j.nbd.2010.04.017 [DOI] [PubMed] [Google Scholar]
- Itami C., Mizuno K., Kohno T., Nakamura S. (2000). Brain-derived neurotrophic factor requirement for activity-dependent maturation of glutamatergic synapse in developing mouse somatosensory cortex. Brain Res. 857, 141–150 10.1016/S0006-8993(99)02352-5 [DOI] [PubMed] [Google Scholar]
- Ito J., Nagayasu Y., Hoshikawa M., Kato K. H., Miura Y., Asai K., et al. (2013). Enhancement of FGF-1 release along with cytosolic proteins from rat astrocytes by hydrogen peroxide. Brain Res. 1522, 12–21 10.1016/j.brainres.2013.05.035 [DOI] [PubMed] [Google Scholar]
- Jeanblanc J., He D. Y., McGough N. N., Logrip M. L., Phamluong K., Janak P. H., et al. (2006). The dopamine D3 receptor is part of a homeostatic pathway regulating ethanol consumption. J. Neurosci. 26, 1457–1464 10.1523/JNEUROSCI.3786-05.2006 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jeffers M., Shimkets R., Prayaga S., Boldog F., Yang M., Burgess C., et al. (2001). Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis. Cancer Res. 61, 3131–3138 [PubMed] [Google Scholar]
- Johnson E. M., Craig E. T., Yeh H. H. (2007). TrkB is necessary for pruning at the climbing fibre-Purkinje cell synapse in the developing murine cerebellum. J. Physiol. 582, 629–646 10.1113/jphysiol.2007.133561 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Johnson-Venkatesh E. M., Umemori H. (2010). Secreted factors as synaptic organizers. Eur. J. Neurosci. 32, 181–190 10.1111/j.1460-9568.2010.07338.x [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kang H., Sun L. D., Atkins C. M., Soderling T. R., Wilson M. A., Tonegawa S. (2001). An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory. Cell 106, 771–783 10.1016/S0092-8674(01)00497-4 [DOI] [PubMed] [Google Scholar]
- Kenny E. M., Cormican P., Furlong S., Heron E., Kenny G., Fahey C., et al. (2013). Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders. Mol. Psychiatry. [Epub ahead of print]. 10.1038/mp.2013.127 [DOI] [PubMed] [Google Scholar]
- Kenyon C. J. (2010). The genetics of ageing. Nature 464, 504–512 10.1038/nature08980 [DOI] [PubMed] [Google Scholar]
- Kim H., Won S., Hwang D. Y., Lee J. S., Kim M., Kim R., et al. (2011). Downregulation of Wnt/beta-catenin signaling causes degeneration of hippocampal neurons in vivo. Neurobiol. Aging 32, 2316.e1–2316.e15 10.1016/j.neurobiolaging.2010.03.013 [DOI] [PubMed] [Google Scholar]
- Kitagishi Y., Kobayashi M., Kikuta K., Matsuda S. (2012). Roles of PI3K/AKT/GSK3/mTOR pathway in cell signaling of mental illnesses. Depress. Res. Treat. 2012:752563 10.1155/2012/752563 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Klint P., Claesson-Welsh L. (1999). Signal transduction by fibroblast growth factor receptors. Front. Biosci. 4, D165–D177 10.2741/Klint [DOI] [PubMed] [Google Scholar]
- Kramer A., Yang F. C., Snodgrass P., Li X., Scammell T. E., Davis F. C., et al. (2001). Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science 294, 2511–2515 10.1126/science.1067716 [DOI] [PubMed] [Google Scholar]
- Kratochwil K., Galceran J., Tontsch S., Roth W., Grosschedl R. (2002). FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice. Genes Dev. 16, 3173–3185 10.1101/gad.1035602 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Krieglstein K., Zheng F., Unsicker K., Alzheimer C. (2011). More than being protective: functional roles for TGF-beta/activin signaling pathways at central synapses. Trends Neurosci. 34, 421–429 10.1016/j.tins.2011.06.002 [DOI] [PubMed] [Google Scholar]
- Krylova O., Herreros J., Cleverley K. E., Ehler E., Henriquez J. P., Hughes S. M., et al. (2002). WNT-3, expressed by motoneurons, regulates terminal arborization of neurotrophin-3-responsive spinal sensory neurons. Neuron 35, 1043–1056 10.1016/S0896-6273(02)00860-7 [DOI] [PubMed] [Google Scholar]
- Kurian M. A., Meyer E., Vassallo G., Morgan N. V., Prakash N., Pasha S., et al. (2010). Phospholipase C beta 1 deficiency is associated with early-onset epileptic encephalopathy. Brain 133, 2964–2970 10.1093/brain/awq238 [DOI] [PubMed] [Google Scholar]
- Ladher R. K., Anakwe K. U., Gurney A. L., Schoenwolf G. C., Francis-West P. H. (2000). Identification of synergistic signals initiating inner ear development. Science 290, 1965–1967 10.1126/science.290.5498.1965 [DOI] [PubMed] [Google Scholar]
- Lai K. O., Wong A. S., Cheung M. C., Xu P., Liang Z., Lok K. C., et al. (2012). TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat. Neurosci. 15, 1506–1515 10.1038/nn.3237 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lako M., Lindsay S., Bullen P., Wilson D. I., Robson S. C., Strachan T. (1998). A novel mammalian wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain. Hum. Mol. Genet. 7, 813–822 [DOI] [PubMed] [Google Scholar]
- Larimore J. L., Chapleau C. A., Kudo S., Theibert A., Percy A. K., Pozzo-Miller L. (2009). Bdnf overexpression in hippocampal neurons prevents dendritic atrophy caused by Rett-associated MECP2 mutations. Neurobiol. Dis. 34, 199–211 10.1016/j.nbd.2008.12.011 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lee C. H., Javed D., Althaus A. L., Parent J. M., Umemori H. (2012). Neurogenesis is enhanced and mossy fiber sprouting arises in FGF7-deficient mice during development. Mol. Cell. Neurosci. 51, 61–67 10.1016/j.mcn.2012.07.010 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lee C. H., Umemori H. (2013). Suppression of epileptogenesis-associated changes in response to seizures in FGF22-deficient mice. Front. Cell. Neurosci. 7:43 10.3389/fncel.2013.00043 [DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted]
- Le-Niculescu H., Patel S. D., Bhat M., Kuczenski R., Faraone S. V., Tsuang M. T., et al. (2009). Convergent functional genomics of genome-wide association data for bipolar disorder: comprehensive identification of candidate genes, pathways and mechanisms. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B, 155–181 10.1002/ajmg.b.30887 [DOI] [PubMed] [Google Scholar]
- Levi-Montalcini R. (1987). The nerve growth factor 35 years later. Science 237, 1154–1162 [DOI] [PubMed] [Google Scholar]
- Li A. J., Suzuki S., Suzuki M., Mizukoshi E., Imamura T. (2002). Fibroblast growth factor-2 increases functional excitatory synapses on hippocampal neurons. Eur. J. Neurosci. 16, 1313–1324 10.1046/j.1460-9568.2002.02193.x [DOI] [PubMed] [Google Scholar]
- Li E., Kim D. H., Cai M., Lee S., Kim Y., Lim E., et al. (2011). Hippocampus-dependent spatial learning and memory are impaired in growth hormone-deficient spontaneous dwarf rats. Endocr. J. 58, 257–267 10.1507/endocrj.K11E-006 [DOI] [PubMed] [Google Scholar]
- Li Z., Thiele C. J. (2007). Targeting Akt to increase the sensitivity of neuroblastoma to chemotherapy: lessons learned from the brain-derived neurotrophic factor/TrkB signal transduction pathway. Expert Opin. Ther. Targets 11, 1611–1621 10.1517/14728222.11.12.1611 [DOI] [PubMed] [Google Scholar]
- Lichtenstein P., Carlstrom E., Rastam M., Gillberg C., Anckarsater H. (2010). The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood. Am. J. Psychiatry 167, 1357–1363 10.1176/appi.ajp.2010.10020223 [DOI] [PubMed] [Google Scholar]
- Lie D. C., Colamarino S. A., Song H. J., Desire L., Mira H., Consiglio A., et al. (2005). Wnt signalling regulates adult hippocampal neurogenesis. Nature 437, 1370–1375 10.1038/nature04108 [DOI] [PubMed] [Google Scholar]
- Lijam N., Paylor R., McDonald M. P., Crawley J. N., Deng C. X., Herrup K., et al. (1997). Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1. Cell 90, 895–905 [DOI] [PubMed] [Google Scholar]
- Lilley B. N., Pan Y. A., Sanes J. R. (2013). SAD kinases sculpt axonal arbors of sensory neurons through long- and short-term responses to neurotrophin signals. Neuron 79, 39–53 10.1016/j.neuron.2013.05.017 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lin T., Sandusky S. B., Xue H., Fishbein K. W., Spencer R. G., Rao M. S., et al. (2003). A central nervous system specific mouse model for thanatophoric dysplasia type II. Hum. Mol. Genet. 12, 2863–2871 10.1093/hmg/ddg309 [DOI] [PubMed] [Google Scholar]
- Liu G., Gu B., He X. P., Joshi R. B., Wackerle H. D., Rodriguiz R. M., et al. (2013). Transient inhibition of TrkB kinase after status epilepticus prevents development of temporal lobe epilepsy. Neuron 79, 31–38 10.1016/j.neuron.2013.04.027 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Liu R. J., Lee F. S., Li X. Y., Bambico F., Duman R. S., Aghajanian G. K. (2012). Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex. Biol. Psychiatry 71, 996–1005 10.1016/j.biopsych.2011.09.030 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Liu X., Ernfors P., Wu H., Jaenisch R. (1995). Sensory but not motor neuron deficits in mice lacking NT4 and BDNF. Nature 375, 238–241 10.1038/375238a0 [DOI] [PubMed] [Google Scholar]
- Loeys B. L., Chen J., Neptune E. R., Judge D. P., Podowski M., Holm T., et al. (2005). A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nat. Genet. 37, 275–281 10.1038/ng1511 [DOI] [PubMed] [Google Scholar]
- Logue M. W., Baldwin C., Guffanti G., Melista E., Wolf E. J., Reardon A. F., et al. (2013). A genome-wide association study of post-traumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus. Mol. Psychiatry 18, 937–942 10.1038/mp.2012.113 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lucas F. R., Salinas P. C. (1997). WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons. Dev. Biol. 192, 31–44 10.1006/dbio.1997.8734 [DOI] [PubMed] [Google Scholar]
- Lynch C. J., Uddin L. Q., Supekar K., Khouzam A., Phillips J., Menon V. (2013). Default mode network in childhood autism: posteromedial cortex heterogeneity and relationship with social deficits. Biol. Psychiatry 74, 212–219 10.1016/j.biopsych.2012.12.013 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lyons W. E., Mamounas L. A., Ricaurte G. A., Coppola V., Reid S. W., Bora S. H., et al. (1999). Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc. Natl. Acad. Sci. U.S.A. 96, 15239–15244 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ma L., Harada T., Harada C., Romero M., Hebert J. M., McConnell S. K., et al. (2002). Neurotrophin-3 is required for appropriate establishment of thalamocortical connections. Neuron 36, 623–634 10.1016/S0896-6273(02)01021-8 [DOI] [PubMed] [Google Scholar]
- Macleod R. J., Moores M. E., Beninger R. J. (2012). Amphetamine stimulates Wnt3 increases in rat nucleus accumbens. Neuroreport 23, 846–850 10.1097/WNR.0b013e328357d868 [DOI] [PubMed] [Google Scholar]
- Manji H. K., Drevets W. C., Charney D. S. (2001). The cellular neurobiology of depression. Nat. Med. 7, 541–547 10.1038/87865 [DOI] [PubMed] [Google Scholar]
- Mardy S., Miura Y., Endo F., Matsuda I., Sztriha L., Frossard P., et al. (1999). Congenital insensitivity to pain with anhidrosis: novel mutations in the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor. Am. J. Hum. Genet. 64, 1570–1579 10.1086/302422 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Margolis R. L., Chuang D. M., Post R. M. (1994). Programmed cell death: implications for neuropsychiatric disorders. Biol. Psychiatry 35, 946–956 [DOI] [PubMed] [Google Scholar]
- Markowska A. L., Mooney M., Sonntag W. E. (1998). Insulin-like growth factor-1 ameliorates age-related behavioral deficits. Neuroscience 87, 559–569 [DOI] [PubMed] [Google Scholar]
- Martin D. J., Smith D. J. (2013). Is there a clinical prodrome of bipolar disorder? A review of the evidence. Expert Rev. Neurother. 13, 89–98 10.1586/ern.12.149 [DOI] [PubMed] [Google Scholar]
- Martinez-Morales J. R., Del Bene F., Nica G., Hammerschmidt M., Bovolenta P., Wittbrodt J. (2005). Differentiation of the vertebrate retina is coordinated by an FGF signaling center. Dev. Cell 8, 565–574 10.1016/j.devcel.2005.01.022 [DOI] [PubMed] [Google Scholar]
- Mason I. (2007). Initiation to end point: the multiple roles of fibroblast growth factors in neural development. Nat. Rev. Neurosci. 8, 583–596 10.1038/nrn2189 [DOI] [PubMed] [Google Scholar]
- Mauceri D., Freitag H. E., Oliveira A. M., Bengtson C. P., Bading H. (2011). Nuclear calcium-VEGFD signaling controls maintenance of dendrite arborization necessary for memory formation. Neuron 71, 117–130 10.1016/j.neuron.2011.04.022 [DOI] [PubMed] [Google Scholar]
- McCormack K., Sanchez M. M., Bardi M., Maestripieri D. (2006). Maternal care patterns and behavioral development of rhesus macaque abused infants in the first 6 months of life. Dev. Psychobiol. 48, 537–550 10.1002/dev.20157 [DOI] [PubMed] [Google Scholar]
- McCoy P. A., Shao Y., Wolpert C. M., Donnelly S. L., Ashley-Koch A., Abel H. L., et al. (2002). No association between the WNT2 gene and autistic disorder. Am. J. Med. Genet. 114, 106–109 10.1002/ajmg.10182 [DOI] [PubMed] [Google Scholar]
- McFarlane S., McNeill L., Holt C. E. (1995). FGF signaling and target recognition in the developing Xenopus visual system. Neuron 15, 1017–1028 [DOI] [PubMed] [Google Scholar]
- McGough N. N., He D. Y., Logrip M. L., Jeanblanc J., Phamluong K., Luong K., et al. (2004). RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addiction. J. Neurosci. 24, 10542–10552 10.1523/JNEUROSCI.3714-04.2004 [DOI] [PMC free article] [PubMed] [Google Scholar]
- McGrath C. L., Glatt S. J., Sklar P., Le-Niculescu H., Kuczenski R., Doyle A. E., et al. (2009). Evidence for genetic association of RORB with bipolar disorder. BMC Psychiatry 9:70 10.1186/1471-244X-9-70 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mei L., Xiong W. C. (2008). Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. Nat. Rev. Neurosci. 9, 437–452 10.1038/nrn2392 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mennerick S., Zorumski C. F. (2000). Neural activity and survival in the developing nervous system. Mol. Neurobiol. 22, 41–54 10.1385/MN:22:1-3:041 [DOI] [PubMed] [Google Scholar]
- Messer C. J., Eisch A. J., Carlezon W. A., Jr., Whisler K., Shen L., Wolf D. H., et al. (2000). Role for GDNF in biochemical and behavioral adaptations to drugs of abuse. Neuron 26, 247–257 10.1016/S0896-6273(00)81154-X [DOI] [PMC free article] [PubMed] [Google Scholar]
- Meyer R. M., Burgos-Robles A., Liu E., Correia S. S., Goosens K. A. (2013). A ghrelin-growth hormone axis drives stress-induced vulnerability to enhanced fear. Mol. Psychiatry. [Epub ahead of print]. 10.1038/mp.2013.135 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Meyer-Franke A., Kaplan M. R., Pfrieger F. W., Barres B. A. (1995). Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture. Neuron 15, 805–819 [DOI] [PubMed] [Google Scholar]
- Meyers E. N., Lewandoski M., Martin G. R. (1998). An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat. Genet. 18, 136–141 10.1038/ng0298-136 [DOI] [PubMed] [Google Scholar]
- Minichiello L. (2009). TrkB signalling pathways in LTP and learning. Nat. Rev. Neurosci. 10, 850–860 10.1038/nrn2738 [DOI] [PubMed] [Google Scholar]
- Minichiello L., Korte M., Wolfer D., Kuhn R., Unsicker K., Cestari V., et al. (1999). Essential role for TrkB receptors in hippocampus-mediated learning. Neuron 24, 401–414 [DOI] [PubMed] [Google Scholar]
- Miraoui H., Dwyer A. A., Sykiotis G. P., Plummer L., Chung W., Feng B., et al. (2013). Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. Am. J. Hum. Genet. 92, 725–743 10.1016/j.ajhg.2013.04.008 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Molina D. P., Ariwodola O. J., Weiner J. L., Brunso-Bechtold J. K., Adams M. M. (2013). Growth hormone and insulin-like growth factor-I alter hippocampal excitatory synaptic transmission in young and old rats. Age (Dordr.) 35, 1575–1587 10.1007/s11357-012-9460-4 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morice E., Farley S., Poirier R., Dallerac G., Chagneau C., Pannetier S., et al. (2013). Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin-Lowry syndrome. Neurobiol. Dis. 58, 156–168 10.1016/j.nbd.2013.05.016 [DOI] [PubMed] [Google Scholar]
- Muenke M., Gripp K. W., McDonald-McGinn D. M., Gaudenz K., Whitaker L. A., Bartlett S. P., et al. (1997). A unique point mutation in the fibroblast growth factor receptor 3 gene (FGFR3) defines a new craniosynostosis syndrome. Am. J. Hum. Genet. 60, 555–564 [PMC free article] [PubMed] [Google Scholar]
- Muinos-Gimeno M., Guidi M., Kagerbauer B., Martin-Santos R., Navines R., Alonso P., et al. (2009). Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders. Hum. Mutat. 30, 1062–1071 10.1002/humu.21005 [DOI] [PubMed] [Google Scholar]
- Mutoh T., Tachi M., Yano S., Mihara T., Yamamoto H. (2005). Impairment of Trk-neurotrophin receptor by the serum of a patient with subacute sensory neuropathy. Arch. Neurol. 62, 1612–1615 10.1001/archneur.62.10.1612 [DOI] [PubMed] [Google Scholar]
- Neale B. M., Kou Y., Liu L., Ma'ayan A., Samocha K. E., Sabo A., et al. (2012). Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature 485, 242–245 10.1038/nature11011 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Neves-Pereira M., Cheung J. K., Pasdar A., Zhang F., Breen G., Yates P., et al. (2005). BDNF gene is a risk factor for schizophrenia in a Scottish population. Mol. Psychiatry 10, 208–212 10.1038/sj.mp.4001575 [DOI] [PubMed] [Google Scholar]
- Neves-Pereira M., Mundo E., Muglia P., King N., Macciardi F., Kennedy J. L. (2002). The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study. Am. J. Hum. Genet. 71, 651–655 10.1086/342288 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nguyen A., Rauch T. A., Pfeifer G. P., Hu V. W. (2010). Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain. FASEB J. 24, 3036–3051 10.1096/fj.10-154484 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Niehrs C. (2012). The complex world of WNT receptor signalling. Nat. Rev. Mol. Cell Biol. 13, 767–779 10.1038/nrm3470 [DOI] [PubMed] [Google Scholar]
- Nikoletopoulou V., Lickert H., Frade J. M., Rencurel C., Giallonardo P., Zhang L., et al. (2010). Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not. Nature 467, 59–63 10.1038/nature09336 [DOI] [PubMed] [Google Scholar]
- Nishimune H., Sanes J. R., Carlson S. S. (2004). A synaptic laminin-calcium channel interaction organizes active zones in motor nerve terminals. Nature 432, 580–587 10.1038/nature03112 [DOI] [PubMed] [Google Scholar]
- Nishiyama M., Skoultchi A. I., Nakayama K. I. (2012). Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-beta-catenin signaling pathway. Mol. Cell. Biol. 32, 501–512 10.1128/MCB.06409-11 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nordstrom U., Maier E., Jessell T. M., Edlund T. (2006). An early role for WNT signaling in specifying neural patterns of Cdx and Hox gene expression and motor neuron subtype identity. PLoS Biol. 4:e252 10.1371/journal.pbio.0040252 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Novak G., Seeman P., Tallerico T. (2000). Schizophrenia: elevated mRNA for calcium-calmodulin-dependent protein kinase IIbeta in frontal cortex. Brain Res. Mol. Brain Res. 82, 95–100 10.1016/S0169-328X(00)00188-1 [DOI] [PubMed] [Google Scholar]
- Nunez A., Carro E., Torres-Aleman I. (2003). Insulin-like growth factor I modifies electrophysiological properties of rat brain stem neurons. J. Neurophysiol. 89, 3008–3017 10.1152/jn.00089.2003 [DOI] [PubMed] [Google Scholar]
- O'Brien W. T., Harper A. D., Jove F., Woodgett J. R., Maretto S., Piccolo S., et al. (2004). Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. J. Neurosci. 24, 6791–6798 10.1523/JNEUROSCI.4753-03.2004 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Okerlund N. D., Cheyette B. N. (2011). Synaptic Wnt signaling-a contributor to major psychiatric disorders? J. Neurodev. Disord. 3, 162–174 10.1007/s11689-011-9083-6 [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Kusky J., Ye P. (2012). Neurodevelopmental effects of insulin-like growth factor signaling. Front. Neuroendocrinol. 33, 230–251 10.1016/j.yfrne.2012.06.002 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Orefice L. L., Waterhouse E. G., Partridge J. G., Lalchandani R. R., Vicini S., Xu B. (2013). Distinct roles for somatically and dendritically synthesized brain-derived neurotrophic factor in morphogenesis of dendritic spines. J. Neurosci. 33, 11618–11632 10.1523/JNEUROSCI.0012-13.2013 [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Roak B. J., Vives L., Fu W., Egertson J. D., Stanaway I. B., Phelps I. G., et al. (2012a). Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders. Science 338, 1619–1622 10.1126/science.1227764 [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Roak B. J., Vives L., Girirajan S., Karakoc E., Krumm N., Coe B. P., et al. (2012b). Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature 485, 246–250 10.1038/nature10989 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ortega S., Ittmann M., Tsang S. H., Ehrlich M., Basilico C. (1998). Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2. Proc. Natl. Acad. Sci. U.S.A. 95, 5672–5677 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Paratcha G., Ledda F. (2008). GDNF and GFRalpha: a versatile molecular complex for developing neurons. Trends Neurosci. 31, 384–391 10.1016/j.tins.2008.05.003 [DOI] [PubMed] [Google Scholar]
- Park M., Shen K. (2012). WNTs in synapse formation and neuronal circuitry. EMBO J. 31, 2697–2704 10.1038/emboj.2012.145 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Patzke H., Ernsberger U. (2000). Expression of neurexin Ialpha splice variants in sympathetic neurons: selective changes during differentiation and in response to neurotrophins. Mol. Cell. Neurosci. 15, 561–572 10.1006/mcne.2000.0853 [DOI] [PubMed] [Google Scholar]
- Perez J. A., Clinton S. M., Turner C. A., Watson S. J., Akil H. (2009). A new role for FGF2 as an endogenous inhibitor of anxiety. J. Neurosci. 29, 6379–6387 10.1523/JNEUROSCI.4829-08.2009 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Perron J. C., Bixby J. L. (1999). Distinct neurite outgrowth signaling pathways converge on ERK activation. Mol. Cell. Neurosci. 13, 362–378 10.1006/mcne.1999.0753 [DOI] [PubMed] [Google Scholar]
- Petrik D., Lagace D. C., Eisch A. J. (2012). The neurogenesis hypothesis of affective and anxiety disorders: are we mistaking the scaffolding for the building? Neuropharmacology 62, 21–34 10.1016/j.neuropharm.2011.09.003 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Poduri A., Chopra S. S., Neilan E. G., Elhosary P. C., Kurian M. A., Meyer E., et al. (2012a). Homozygous PLCB1 deletion associated with malignant migrating partial seizures in infancy. Epilepsia 53, e146–e150 10.1111/j.1528-1167.2012.03538.x [DOI] [PMC free article] [PubMed] [Google Scholar]
- Poduri A., Evrony G. D., Cai X., Elhosary P. C., Beroukhim R., Lehtinen M. K., et al. (2012b). Somatic activation of AKT3 causes hemispheric developmental brain malformations. Neuron 74, 41–48 10.1016/j.neuron.2012.03.010 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pollitt A. Y., Insall R. H. (2009). WASP and SCAR/WAVE proteins: the drivers of actin assembly. J. Cell Sci. 122, 2575–2578 10.1242/jcs.023879 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Poon V. Y., Choi S., Park M. (2013). Growth factors in synaptic function. Front. Synaptic Neurosci. 5:6 10.3389/fnsyn.2013.00006 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Priolo M., Lerone M., Baffico M., Baldi M., Ravazzolo R., Cama A., et al. (2000). Pfeiffer syndrome type 2 associated with a single amino acid deletion in the FGFR2 gene. Clin. Genet. 58, 81–83 10.1034/j.1399-0004.2000.580116.x [DOI] [PubMed] [Google Scholar]
- Pyott S. M., Tran T. T., Leistritz D. F., Pepin M. G., Mendelsohn N. J., Temme R. T., et al. (2013). WNT1 mutations in families affected by moderately severe and progressive recessive osteogenesis imperfecta. Am. J. Hum. Genet. 92, 590–597 10.1016/j.ajhg.2013.02.009 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Qi X. R., Zhao J., Liu J., Fang H., Swaab D. F., Zhou J. N. (2013). Abnormal Retinoid and TrkB Signaling in the Prefrontal Cortex in Mood Disorders. Cereb. Cortex. [Epub ahead of print]. 10.1093/cercor/bht203 [DOI] [PubMed] [Google Scholar]
- Quevedo C., Alcazar A., Salinas M. (2000). Two different signal transduction pathways are implicated in the regulation of initiation factor 2B activity in insulin-like growth factor-1-stimulated neuronal cells. J. Biol. Chem. 275, 19192–19197 10.1074/jbc.M000238200 [DOI] [PubMed] [Google Scholar]
- Raile K., Klammt J., Schneider A., Keller A., Laue S., Smith R., et al. (2006). Clinical and functional characteristics of the human Arg59Ter insulin-like growth factor i receptor (IGF1R) mutation: implications for a gene dosage effect of the human IGF1R. J. Clin. Endocrinol. Metab. 91, 2264–2271 10.1210/jc.2005-2146 [DOI] [PubMed] [Google Scholar]
- Ramsey M. M., Adams M. M., Ariwodola O. J., Sonntag W. E., Weiner J. L. (2005). Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus. J. Neurophysiol. 94, 247–254 10.1152/jn.00768.2004 [DOI] [PubMed] [Google Scholar]
- Ray P., Devaux Y., Stolz D. B., Yarlagadda M., Watkins S. C., Lu Y., et al. (2003). Inducible expression of keratinocyte growth factor (KGF) in mice inhibits lung epithelial cell death induced by hyperoxia. Proc. Natl. Acad. Sci. U.S.A. 100, 6098–6103 10.1073/pnas.1031851100 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reardon W., Wilkes D., Rutland P., Pulleyn L. J., Malcolm S., Dean J. C., et al. (1997). Craniosynostosis associated with FGFR3 pro250arg mutation results in a range of clinical presentations including unisutural sporadic craniosynostosis. J. Med. Genet. 34, 632–636 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reichardt L. F. (2006). Neurotrophin-regulated signalling pathways. Philos. Trans. R. Soc. Lond. B Biol. Sci. 361, 1545–1564 10.1098/rstb.2006.1894 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ribases M., Gratacos M., Armengol L., De Cid R., Badia A., Jimenez L., et al. (2003). Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type. Mol. Psychiatry 8, 745–751 10.1038/sj.mp.4001281 [DOI] [PubMed] [Google Scholar]
- Ribases M., Gratacos M., Fernandez-Aranda F., Bellodi L., Boni C., Anderluh M., et al. (2004). Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations. Hum. Mol. Genet. 13, 1205–1212 10.1093/hmg/ddh137 [DOI] [PubMed] [Google Scholar]
- Rosch H., Schweigreiter R., Bonhoeffer T., Barde Y. A., Korte M. (2005). The neurotrophin receptor p75NTR modulates long-term depression and regulates the expression of AMPA receptor subunits in the hippocampus. Proc. Natl. Acad. Sci. U.S.A. 102, 7362–7367 10.1073/pnas.0502460102 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rosso S. B., Inestrosa N. C. (2013). WNT signaling in neuronal maturation and synaptogenesis. Front. Cell. Neurosci. 7:103 10.3389/fncel.2013.00103 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rosso S. B., Sussman D., Wynshaw-Boris A., Salinas P. C. (2005). Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development. Nat. Neurosci. 8, 34–42 10.1038/nn1374 [DOI] [PubMed] [Google Scholar]
- Russo E., Citraro R., Constanti A., De Sarro G. (2012). The mTOR signaling pathway in the brain: focus on epilepsy and epileptogenesis. Mol. Neurobiol. 46, 662–681 10.1007/s12035-012-8314-5 [DOI] [PubMed] [Google Scholar]
- Sanchez M. M., Alagbe O., Felger J. C., Zhang J., Graff A. E., Grand A. P., et al. (2007). Activated p38 MAPK is associated with decreased CSF 5-HIAA and increased maternal rejection during infancy in rhesus monkeys. Mol. Psychiatry 12, 895–897 10.1038/sj.mp.4002025 [DOI] [PubMed] [Google Scholar]
- Sanhueza M., McIntyre C. C., Lisman J. E. (2007). Reversal of synaptic memory by Ca2+/calmodulin-dependent protein kinase II inhibitor. J. Neurosci. 27, 5190–5199 10.1523/JNEUROSCI.5049-06.2007 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sarachana T., Hu V. W. (2013). Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder. Mol. Autism 4, 14 10.1186/2040-2392-4-14 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Scearce-Levie K., Roberson E. D., Gerstein H., Cholfin J. A., Mandiyan V. S., Shah N. M., et al. (2008). Abnormal social behaviors in mice lacking Fgf17. Genes Brain Behav. 7, 344–354 10.1111/j.1601-183X.2007.00357.x [DOI] [PubMed] [Google Scholar]
- Schmeisser M. J., Baumann B., Johannsen S., Vindedal G. F., Jensen V., Hvalby O. C., et al. (2012). IkappaB kinase/nuclear factor kappaB-dependent insulin-like growth factor 2 (Igf2) expression regulates synapse formation and spine maturation via Igf2 receptor signaling. J. Neurosci. 32, 5688–5703 10.1523/JNEUROSCI.0111-12.2012 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schmitt A. M., Shi J., Wolf A. M., Lu C. C., King L. A., Zou Y. (2006). Wnt-Ryk signalling mediates medial-lateral retinotectal topographic mapping. Nature 439, 31–37 10.1038/nature04334 [DOI] [PubMed] [Google Scholar]
- Schulz J., Sundin J., Leask S., Done D. J. (2014). Risk of adult schizophrenia and its relationship to childhood IQ in the 1958 British birth cohort. Schizophr. Bull. 40, 143–151 10.1093/schbul/sbs157 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schumacher J., Jamra R. A., Becker T., Ohlraun S., Klopp N., Binder E. B., et al. (2005). Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Biol. Psychiatry 58, 307–314 10.1016/j.biopsych.2005.04.006 [DOI] [PubMed] [Google Scholar]
- Sen S., Duman R., Sanacora G. (2008). Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol. Psychiatry 64, 527–532 10.1016/j.biopsych.2008.05.005 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sensi A., Ceruti S., Trevisi P., Gualandi F., Busi M., Donati I., et al. (2011). LAMM syndrome with middle ear dysplasia associated with compound heterozygosity for FGF3 mutations. Am. J. Med. Genet. A 155A, 1096–1101 10.1002/ajmg.a.33962 [DOI] [PubMed] [Google Scholar]
- Shin D. M., Korada S., Raballo R., Shashikant C. S., Simeone A., Taylor J. R., et al. (2004). Loss of glutamatergic pyramidal neurons in frontal and temporal cortex resulting from attenuation of FGFR1 signaling is associated with spontaneous hyperactivity in mice. J. Neurosci. 24, 2247–2258 10.1523/JNEUROSCI.5285-03.2004 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shotelersuk V., Ittiwut C., Srivuthana S., Mahatumarat C., Lerdlum S., Wacharasindhu S. (2002). Distinct craniofacial-skeletal-dermatological dysplasia in a patient with W290C mutation in FGFR2. Am. J. Med. Genet. 113, 4–8 10.1002/ajmg.10449 [DOI] [PubMed] [Google Scholar]
- Smeyne R. J., Klein R., Schnapp A., Long L. K., Bryant S., Lewin A., et al. (1994). Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 368, 246–249 10.1038/368246a0 [DOI] [PubMed] [Google Scholar]
- Smoller J. W., Finn C. T. (2003). Family, twin, and adoption studies of bipolar disorder. Am. J. Med. Genet. C Semin. Med. Genet. 123C, 48–58 10.1002/ajmg.c.20013 [DOI] [PubMed] [Google Scholar]
- Squarzoni P., Parveen F., Zanetti L., Ristoratore F., Spagnuolo A. (2011). FGF/MAPK/Ets signaling renders pigment cell precursors competent to respond to Wnt signal by directly controlling Ci-Tcf transcription. Development 138, 1421–1432 10.1242/dev.057323 [DOI] [PubMed] [Google Scholar]
- Squassina A., Costa M., Congiu D., Manchia M., Angius A., Deiana V., et al. (2013). Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients. Pharmacol. Res. 73, 1–7 10.1016/j.phrs.2013.04.004 [DOI] [PubMed] [Google Scholar]
- Stevens H. E., Smith K. M., Maragnoli M. E., Fagel D., Borok E., Shanabrough M., et al. (2010). Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits. J. Neurosci. 30, 5590–5602 10.1523/JNEUROSCI.5837-09.2010 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stockmeier C. A., Mahajan G. J., Konick L. C., Overholser J. C., Jurjus G. J., Meltzer H. Y., et al. (2004). Cellular changes in the postmortem hippocampus in major depression. Biol. Psychiatry 56, 640–650 10.1016/j.biopsych.2004.08.022 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stockmeier C. A., Rajkowska G. (2004). Cellular abnormalities in depression: evidence from postmortem brain tissue. Dialogues Clin. Neurosci. 6, 185–197 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stroppolo A., Guinea B., Tian C., Sommer J., Ehrlich M. E. (2001). Role of phosphatidylinositide 3-kinase in brain-derived neurotrophic factor-induced DARPP-32 expression in medium size spiny neurons in vitro. J. Neurochem. 79, 1027–1032 10.1046/j.1471-4159.2001.00651.x [DOI] [PubMed] [Google Scholar]
- Sudhof T. C. (2008). Neuroligins and neurexins link synaptic function to cognitive disease. Nature 455, 903–911 10.1038/nature07456 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sullivan P. F., Magnusson C., Reichenberg A., Boman M., Dalman C., Davidson M., et al. (2012). Family history of schizophrenia and bipolar disorder as risk factors for autism. Arch. Gen. Psychiatry 69, 1099–1103 10.1001/archgenpsychiatry.2012.730 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tabatadze N., Tomas C., McGonigal R., Lin B., Schook A., Routtenberg A. (2012). Wnt transmembrane signaling and long-term spatial memory. Hippocampus 22, 1228–1241 10.1002/hipo.20991 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Talkowski M. E., Rosenfeld J. A., Blumenthal I., Pillalamarri V., Chiang C., Heilbut A., et al. (2012). Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries. Cell 149, 525–537 10.1016/j.cell.2012.03.028 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tartaglia M., Valeri S., Velardi F., Di Rocco C., Battaglia P. A. (1997). Trp290Cys mutation in exon IIIa of the fibroblast growth factor receptor 2 (FGFR2) gene is associated with Pfeiffer syndrome. Hum. Genet. 99, 602–606 [DOI] [PubMed] [Google Scholar]
- Tavormina P. L., Bellus G. A., Webster M. K., Bamshad M. J., Fraley A. E., McIntosh I., et al. (1999). A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene. Am. J. Hum. Genet. 64, 722–731 10.1086/302275 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tekin M., Hismi B. O., Fitoz S., Ozdag H., Cengiz F. B., Sirmaci A., et al. (2007). Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia. Am. J. Hum. Genet. 80, 338–344 10.1086/510920 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tekin M., Ozturkmen Akay H., Fitoz S., Birnbaum S., Cengiz F. B., Sennaroglu L., et al. (2008). Homozygous FGF3 mutations result in congenital deafness with inner ear agenesis, microtia, and microdontia. Clin. Genet. 73, 554–565 10.1111/j.1399-0004.2008.01004.x [DOI] [PubMed] [Google Scholar]
- Teng H. K., Teng K. K., Lee R., Wright S., Tevar S., Almeida R. D., et al. (2005). ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J. Neurosci. 25, 5455–5463 10.1523/JNEUROSCI.5123-04.2005 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Terauchi A., Johnson-Venkatesh E. M., Toth A. B., Javed D., Sutton M. A., Umemori H. (2010). Distinct FGFs promote differentiation of excitatory and inhibitory synapses. Nature 465, 783–787 10.1038/nature09041 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Terracciano A., Tanaka T., Sutin A. R., Sanna S., Deiana B., Lai S., et al. (2010). Genome-wide association scan of trait depression. Biol. Psychiatry 68, 811–817 10.1016/j.biopsych.2010.06.030 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Terwisscha Van Scheltinga A. F., Bakker S. C., Kahn R. S. (2010). Fibroblast growth factors in schizophrenia. Schizophr. Bull. 36, 1157–1166 10.1093/schbul/sbp033 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tesseur I., Zou K., Esposito L., Bard F., Berber E., Can J. V., et al. (2006). Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology. J. Clin. Invest. 116, 3060–3069 10.1172/JCI27341 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thompson Ray M., Weickert C. S., Wyatt E., Webster M. J. (2011). Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders. J. Psychiatry Neurosci. 36, 195–203 10.1503/jpn.100048 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Toydemir R. M., Brassington A. E., Bayrak-Toydemir P., Krakowiak P. A., Jorde L. B., Whitby F. G., et al. (2006). A novel mutation in FGFR3 causes camptodactyly, tall stature, and hearing loss (CATSHL) syndrome. Am. J. Hum. Genet. 79, 935–941 10.1086/508433 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tripp A., Oh H., Guilloux J. P., Martinowich K., Lewis D. A., Sibille E. (2012). Brain-derived neurotrophic factor signaling and subgenual anterior cingulate cortex dysfunction in major depressive disorder. Am. J. Psychiatry 169, 1194–1202 10.1176/appi.ajp.2012.12020248 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tropea D., Giacometti E., Wilson N. R., Beard C., McCurry C., Fu D. D., et al. (2009). Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice. Proc. Natl. Acad. Sci. U.S.A. 106, 2029–2034 10.1073/pnas.0812394106 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tropea D., Kreiman G., Lyckman A., Mukherjee S., Yu H., Horng S., et al. (2006). Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex. Nat. Neurosci. 9, 660–668 10.1038/nn1689 [DOI] [PubMed] [Google Scholar]
- Turner C. A., Akil H., Watson S. J., Evans S. J. (2006). The fibroblast growth factor system and mood disorders. Biol. Psychiatry 59, 1128–1135 10.1016/j.biopsych.2006.02.026 [DOI] [PubMed] [Google Scholar]
- Turner C. A., Lewis M. H., King M. A. (2003). Environmental enrichment: effects on stereotyped behavior and dendritic morphology. Dev. Psychobiol. 43, 20–27 10.1002/dev.10116 [DOI] [PubMed] [Google Scholar]
- Turner C. A., Watson S. J., Akil H. (2012). The fibroblast growth factor family: neuromodulation of affective behavior. Neuron 76, 160–174 10.1016/j.neuron.2012.08.037 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Uddin L. Q., Supekar K., Lynch C. J., Khouzam A., Phillips J., Feinstein C., et al. (2013). Salience network-based classification and prediction of symptom severity in children with autism. JAMA Psychiatry 70, 869–879 10.1001/jamapsychiatry.2013.104 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Umemori H. (2009). Weaving the neuronal net with target-derived fibroblast growth factors. Dev. Growth Differ. 51, 263–270 10.1111/j.1440-169X.2008.01079.x [DOI] [PubMed] [Google Scholar]
- Umemori H., Linhoff M. W., Ornitz D. M., Sanes J. R. (2004). FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain. Cell 118, 257–270 10.1016/j.cell.2004.06.025 [DOI] [PubMed] [Google Scholar]
- Utge S. J., Soronen P., Loukola A., Kronholm E., Ollila H. M., Pirkola S., et al. (2010). Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance. PLoS ONE 5:e9259 10.1371/journal.pone.0009259 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Uusitalo M., Heikkila M., Vainio S. (1999). Molecular genetic studies of Wnt signaling in the mouse. Exp. Cell Res. 253, 336–348 10.1006/excr.1999.4710 [DOI] [PubMed] [Google Scholar]
- Van Amerongen R., Berns A. (2006). Knockout mouse models to study Wnt signal transduction. Trends Genet. 22, 678–689 10.1016/j.tig.2006.10.001 [DOI] [PubMed] [Google Scholar]
- Van Der Walt J. M., Noureddine M. A., Kittappa R., Hauser M. A., Scott W. K., McKay R., et al. (2004). Fibroblast growth factor 20 polymorphisms and haplotypes strongly influence risk of Parkinson disease. Am. J. Hum. Genet. 74, 1121–1127 10.1086/421052 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Van Kesteren R. E., Gagatek J. S., Hagendorf A., Gouwenberg Y., Smit A. B., Syed N. I. (2008). Postsynaptic expression of an epidermal growth factor receptor regulates cholinergic synapse formation between identified molluscan neurons. Eur. J. Neurosci. 27, 2043–2056 10.1111/j.1460-9568.2008.06189.x [DOI] [PubMed] [Google Scholar]
- Varela-Nallar L., Alfaro I. E., Serrano F. G., Parodi J., Inestrosa N. C. (2010). Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses. Proc. Natl. Acad. Sci. U.S.A. 107, 21164–21169 10.1073/pnas.1010011107 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vernes S. C., Newbury D. F., Abrahams B. S., Winchester L., Nicod J., Groszer M., et al. (2008). A functional genetic link between distinct developmental language disorders. N. Engl. J. Med. 359, 2337–2345 10.1056/NEJMoa0802828 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vicario-Abejon C., Collin C., McKay R. D., Segal M. (1998). Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons. J. Neurosci. 18, 7256–7271 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vyssotski A. L., Dell'omo G., Poletaeva I. I, Vyssotsk D. L., Minichiello L., Klein R., et al. (2002). Long-term monitoring of hippocampus-dependent behavior in naturalistic settings: mutant mice lacking neurotrophin receptor TrkB in the forebrain show spatial learning but impaired behavioral flexibility. Hippocampus 12, 27–38 10.1002/hipo.10002 [DOI] [PubMed] [Google Scholar]
- Wang G., Van Der Walt J. M., Mayhew G., Li Y. J., Zuchner S., Scott W. K., et al. (2008). Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. Am. J. Hum. Genet. 82, 283–289 10.1016/j.ajhg.2007.09.021 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wassink T. H., Piven J., Vieland V. J., Huang J., Swiderski R. E., Pietila J., et al. (2001). Evidence supporting WNT2 as an autism susceptibility gene. Am. J. Med. Genet. 105, 406–413 10.1002/ajmg.1401 [DOI] [PubMed] [Google Scholar]
- Wei F., Qiu C. S., Liauw J., Robinson D. A., Ho N., Chatila T., et al. (2002). Calcium calmodulin-dependent protein kinase IV is required for fear memory. Nat. Neurosci. 5, 573–579 10.1038/nn855 [DOI] [PubMed] [Google Scholar]
- Wider C., Dachsel J. C., Soto A. I., Heckman M. G., Diehl N. N., Yue M., et al. (2009). FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression. Mov. Disord. 24, 455–459 10.1002/mds.22442 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Williams E. L., Casanova M. F. (2011). Above genetics: lessons from cerebral development in autism. Transl. Neurosci. 2, 106–120 10.2478/s13380-011-0016-3 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Williamson W. R., Hiesinger P. R. (2008). Synaptic patterning by morphogen signaling. Sci. Signal. 1:pe20 10.1126/stke.118pe20 [DOI] [PubMed] [Google Scholar]
- Wong M. (2013). Mammalian target of rapamycin (mTOR) pathways in neurological diseases. Biomed. J. 36, 40–50 10.4103/2319-4170.110365 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wurdak H., Ittner L. M., Lang K. S., Leveen P., Suter U., Fischer J. A., et al. (2005). Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome. Genes Dev. 19, 530–535 10.1101/gad.317405 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wyss-Coray T., Borrow P., Brooker M. J., Mucke L. (1997). Astroglial overproduction of TGF-beta 1 enhances inflammatory central nervous system disease in transgenic mice. J. Neuroimmunol. 77, 45–50 [DOI] [PubMed] [Google Scholar]
- Wyss-Coray T., Lin C., Yan F., Yu G. Q., Rohde M., McConlogue L., et al. (2001). TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. Nat. Med. 7, 612–618 10.1038/87945 [DOI] [PubMed] [Google Scholar]
- Xie C. W., Sayah D., Chen Q. S., Wei W. Z., Smith D., Liu X. (2000). Deficient long-term memory and long-lasting long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene. Proc. Natl. Acad. Sci. U.S.A. 97, 8116–8121 10.1073/pnas.140204597 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Xu B., Goulding E. H., Zang K., Cepoi D., Cone R. D., Jones K. R., et al. (2003). Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat. Neurosci. 6, 736–742 10.1038/nn1073 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yamanaka Y., Kitano A., Takao K., Prasansuklab A., Mushiroda T., Yamazaki K., et al. (2011). Inactivation of fibroblast growth factor binding protein 3 causes anxiety-related behaviors. Mol. Cell. Neurosci. 46, 200–212 10.1016/j.mcn.2010.09.003 [DOI] [PubMed] [Google Scholar]
- Yilmazer-Hanke D. M., Faber-Zuschratter H., Blumcke I., Bickel M., Becker A., Mawrin C., et al. (2007). Axo-somatic inhibition of projection neurons in the lateral nucleus of amygdala in human temporal lobe epilepsy: an ultrastructural study. Exp. Brain Res. 177, 384–399 10.1007/s00221-006-0680-7 [DOI] [PubMed] [Google Scholar]
- Yoshii A., Murata Y., Kim J., Zhang C., Shokat K. M., Constantine-Paton M. (2011). TrkB and protein kinase Mzeta regulate synaptic localization of PSD-95 in developing cortex. J. Neurosci. 31, 11894–11904 10.1523/JNEUROSCI.2190-11.2011 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yu H., Wang D. D., Wang Y., Liu T., Lee F. S., Chen Z. Y. (2012). Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants. J. Neurosci. 32, 4092–4101 10.1523/JNEUROSCI.5048-11.2012 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yu H., Wang Y., Pattwell S., Jing D., Liu T., Zhang Y., et al. (2009). Variant BDNF Val66Met polymorphism affects extinction of conditioned aversive memory. J. Neurosci. 29, 4056–4064 10.1523/JNEUROSCI.5539-08.2009 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zeev B. B., Bebbington A., Ho G., Leonard H., De Klerk N., Gak E., et al. (2009). The common BDNF polymorphism may be a modifier of disease severity in Rett syndrome. Neurology 72, 1242–1247 10.1212/01.wnl.0000345664.72220.6a [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zha X. M., Bishop J. F., Hansen M. R., Victoria L., Abbas P. J., Mouradian M. M., et al. (2001). BDNF synthesis in spiral ganglion neurons is constitutive and CREB-dependent. Hear. Res. 156, 53–68 10.1016/S0378-5955(01)00267-2 [DOI] [PubMed] [Google Scholar]
- Zhang X., Zhu J., Yang G. Y., Wang Q. J., Qian L., Chen Y. M., et al. (2007). Dishevelled promotes axon differentiation by regulating atypical protein kinase C. Nat. Cell Biol. 9, 743–754 10.1038/ncb1603 [DOI] [PubMed] [Google Scholar]
- Zintzaras E. (2007). Brain-derived neurotrophic factor gene polymorphisms and schizophrenia: a meta-analysis. Psychiatr. Genet. 17, 69–75 10.1097/YPG.0b013e32801119da [DOI] [PubMed] [Google Scholar]
- Zorner B., Wolfer D. P., Brandis D., Kretz O., Zacher C., Madani R., et al. (2003). Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than “depressive.” Biol. Psychiatry 54, 972–982 10.1016/S0006-3223(03)00418-9 [DOI] [PubMed] [Google Scholar]
- Zuko A., Kleijer K. T., Oguro-Ando A., Kas M. J., Van Daalen E., Van Der Zwaag B., et al. (2013). Contactins in the neurobiology of autism. Eur. J. Pharmacol. 719, 63–74 10.1016/j.ejphar.2013.07.016 [DOI] [PubMed] [Google Scholar]