Table 1. Principal clinical and biologic characteristics of the patients of the cohort 1 and cohort 2.

	Cohort 1	Cohort 1
N of patients	28	71
M/F	16/12	49/22
Age mean yrs (range)	65 (50-91)	64 (38-86)
Stage (Binet) a/b/c	28/0/0	63/8/0
FISH neg/13q deletion	14/14	40/31
ZAP70 (>30%) neg/pos	22/5	61/10
IGHV mut/unmut	20/2	60/11
TP53 mut/unmut	0/18	0/69