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. Author manuscript; available in PMC: 2015 Feb 28.
Published in final edited form as: Neuroscience. 2013 Dec 16;260:171–184. doi: 10.1016/j.neuroscience.2013.12.018

Fig 10. A2AR Agonist CGS-21680 Increases mEPSP frequency and decreased median mEPSP amplitude.

Fig 10

A. Changes in the frequency of mEPSPs after application of selective adenosine receptor ligands (shown as % of control). Individual neurons are shown in grey, with averages denoted by black symbols. In N = 11 neurons, the A2AR agonist CGS-21680 (30 nM) increased the frequency of mEPSPs (black circle). In another N = 15 neurons, the A1R antagonist DPCPX (30nM) also increased the frequency of mEPSPs (black diamond). After application of DPCPX, subsequent addition of 30 nM CGS-21680 to these same neurons did not lead to further increase of mEPSP frequency (black triangle).

B. Changes in the amplitude of the median mEPSP after CGS-21680 application. In N = 11 neurons, the A2AR agonist CGS-21680 (30 nM) decreased the median mEPSP amplitude (black line). In N = 14 neurons, on the background of 30 nM DPCPX (grey line), 30nM CGS-21680 decreased the median mEPSP amplitude (grey line).