Changes in PPR plotted against changes in the EPSP1 amplitude. The changes in PPR and EPSP1 amplitude were correlated in all three groups of experiments: Experiments with the application of adenosine at different concentrations (5-50 μM, open circles, r = -0.62, n = 39, p < 0.001); experiments utilizing application of 20 μM adenosine on the background of different concentrations of DPCPX (1.5 - 150 nM, closed circles; r = -0.69, n = 52, p < 0.001); and the control group for these experiments, which utilized 20 μM adenosine but no DPCPX (grey circles, r = −0.55, n = 13, p < 0.05). The changes in EPSP amplitude and PPR are inversely related during all manipulations of A1R activation.