Abstract
Background
Decrease of dual-task (DT) ability is known to be one of the risk factors for falls. We developed a new game concept, Dual-Task Tai Chi (DTTC), using Microsoft’s motion-capture device Kinect, and demonstrated that the DTTC test can quantitatively evaluate various functions that are known risk factors for falling in elderly adults. Moreover, DT training has been attracting attention as a way to improve balance and DT ability. However, only a few studies have reported that it improves cognitive performance.
Objective
The purpose of this study was to demonstrate whether or not a 12-week program of DTTC training would effectively improve cognitive functions.
Methods
This study examined cognitive functions in community-dwelling older adults before and after 12 weeks of DTTC training (training group [TG]) or standardized training (control group [CG]). Primary end points were based on the difference in cognitive functions between the TG and the CG. Cognitive functions were evaluated using the trail-making test (part A and part B) and verbal fluency test.
Results
A total of 41 elderly individuals (TG: n=26, CG: n=15) participated in this study and their cognitive functions were assessed before and after DTTC training. Significant differences were observed between the two groups with significant group × time interactions for the executive cognitive function measure, the delta-trail-making test (part B−part A; F 1,36=4.94, P=.03; TG: pre mean 48.8 [SD 43.9], post mean 42.2 [SD 29.0]; CG: pre mean 49.5 [SD 51.8], post mean 64.9 [SD 54.7]).
Conclusions
The results suggest that DTTC training is effective for improving executive cognitive functions.
Trial Registration
Japan Medical Association Clinical Trial Registration Number: JMA-IIA00092; https://dbcentre3.jmacct.med.or.jp/jmactr/App/JMACTRS06/JMACTRS06.aspx?seqno=2682 (Archived by WebCite at http://www.webcitation.org/6NRtOkZFh).
Keywords: fall prevention, cognitive function, dual-task, training, elderly
Introduction
Cognitive impairment among elderly individuals is a serious issue in many countries. Many investigators have developed different cognitive function training methods as countermeasures to prevent cognitive impairment and have reported their effects [1]. Other investigators also have reported the effects of physical exercise training on cognitive functions among elderly individuals [2,3]. Additionally, Hillman et al and Silsupado have indicated that executive cognitive functions, which are related to the control of goal-oriented actions and adaptive behaviors, are strongly impaired by aging and respond positively to exercise training [4,5].
Recently, dual-task (DT) ability, or the performance of simultaneous motor and cognitive tasks, has been receiving considerable attention [6]. DT training is now recognized as a fall prevention tool that enhances physical functions among elderly people [7].
With a focus on DT, we developed a new concept called the Dual-Task Tai Chi (DTTC) test [8]. This system was developed using Kinect (Microsoft, Redmond, WA, USA), a motion-capture device, and demonstrated that the DTTC test quantitatively evaluates compound functions, including DT, balance, and cognitive abilities in elderly people [9]. In unpublished data, we found that DTTC training was useful not only to assess but also to improve balance and mobility among elderly people [10].
Several investigators have reported the effects of DT training on balance, mobility, walking, and DT ability [11,12]. However, only a few have reported that DT training improves cognitive performance. We reported that Trail-Walking Exercise, which is similar to Trail-Making Test (TMT) under DT condition, improved executive cognitive functions [13]. According to this, we expected that DTTC training would improve cognitive functions as well, especially executive functions. Therefore, the purpose of this study was to reveal that training with the DTTC device affects cognitive performance in elderly individuals.
Methods
Participants
Community-dwelling elderly subjects (n=48) participated in this study. The subjects were recruited through an advertisement in the local press. The following selection criteria were used: age ≥65 years, community dwelling, independent ambulation, willingness to participate in the measurement of physical fitness, and minimal hearing and vision impairment. Exclusion criteria were as follows: inability to complete the tasks because of reduced cognitive functions, evaluated by Rapid Dementia Screening Test [14] scored 8 or greater; severe cardiac, pulmonary, or musculoskeletal disorders; pathologies associated with increased risk of falls, such as Parkinson’s disease or stroke; osteoporosis; and psychotropic drug use. We obtained written informed consent from each participant. This study was approved (protocol approval E- 880) by the Ethical Review Board of Kyoto University Graduate School of Medicine, Kyoto, Japan.
Device
The DTTC test [8-10] requires users to solve a number placement problem (Sudoku) by controlling a stick figure with the movement of their entire body. The user’s full-body motion is captured using Kinect and is translated into movements for the stick figure on a screen. The cognitive task is to fill in 3 boxes chosen at random from a 4 × 4 grid with digits ranging from 1 to 4. The user selects a digit using his or her right hand and left foot and points to a box with his or her left hand. In addition, the user must move his or her right hand to the left hand to fill the indicated box with the selected digit. As such, full-body motion, similar to Tai Chi Chuan movements, is required. We recorded the time taken to fill in all 3 boxes, as our evaluation index.
To begin with, the user stands 3 m in front of the Kinect sensor with his or her right foot in front of the sensor (Figure 1). The following instructions were provided:
Figure 1.
View of the Dual-Task Tai Chi (DTTC) test.
Reach a digit you need to use with your right hand to fill a blank you want to answer.
Step 50 cm laterally, with your left leg, to grip the digit in your right hand.
Select the blank you want to answer with your left hand, and move your right hand to your left one.
Intervention
All subjects participated in group training sessions lasting 75-80 minutes once a week for 12 weeks. The participants were divided into two training groups according to their participation in the exercise class: (1) the control group (CG), 75-minute standardized training, and (2) the training group (TG), 5-minute DTTC training, in addition to the standardized training [10].
The exercise classes were individualized for each group and were supervised by physical therapists. Each exercise class used a standardized format that included 15 minutes of moderate-intensity aerobic exercise, 15 minutes of progressive strength training, 10 minutes of flexibility and balance exercises, and 10 minutes of cool-down activities, followed by exercises known to improve muscle strength and balance [15,16]. In addition, the class included a 25-minute rhythmic stepping exercise involving cognitive ability, which is an exercise intended to improve DT ability [11], before cool-down.
The participants in the TG were additionally asked to solve DTTC problems and mirror-reversed DTTC problems, alternately, as many times possible in 5 minutes.
Outcome Measures
All participants underwent evaluation upon entry into the study (pre-intervention) and at the end of the study (post-intervention), using the results of 2 cognitive performance tests.
Cognitive functions were evaluated using the trail-making test (TMT) [17] and verbal fluency test (VFT) [18-20]. The TMT is a well-established psychomotor test originally developed as part of the Army Individual Test Battery. The TMT has been widely used in clinical evaluations to assess deficits in executive cognitive functions. The test consists of 2 parts: part A is a visual-scanning task and part B is a measure of cognitive flexibility. For this analysis, we used a different score defined as delta-TMT, calculated as the difference between the times for each part (part B-part A). The delta-TMT score is used to control for the effect of motor speed on TMT performance and is considered a more accurate measure of executive functions than performance on part B alone [20,21].
The VFT has a letter fluency component and a category fluency component. Participants were asked to think of as many animal names as possible in 1 minute (category fluency). Verbal fluency is an evaluation of expressive language ability and executive functions. The score was the number of successful words (except for some proper nouns).
Statistical Analysis
We compared baseline characteristics between the participants in each group to examine the comparability between the 2 groups using Student’s t test or the chi-square test. Repeated-measures, mixed-linear, two-way ANCOVA (analysis of covariance) was used to analyze the effect of exercise on outcome measurements while adjusting for each cognitive performance, at pre-intervention, as a covariate.
Data were entered and analyzed using the Statistical Package for the Social Sciences (Windows version 20.0, SPSS Inc., Chicago, IL, USA). For all analyses, P<.05 was considered statistically significant.
Results
Study Population
A total of 41 of the 48 selected subjects (85.4%) completed the study protocols and returned for their exit interviews and final testing (TG: n=26, CG: n=15). The participants’ baseline data did not differ significantly between the two groups. Thus, the groups were comparable and well matched with regard to their baseline characteristics.
Adherence to the Study Protocols
During the 12-week intervention phase, 10 exercise sessions were scheduled and all took place. Excluding the 4 participants who dropped out, the TG subjects had an overall attendance rate of 82% and the CG subjects had an overall attendance rate of 81% over the 12 weeks. No health problems, including cardiovascular or musculoskeletal complications, occurred during training sessions or testing. Moreover, almost all participants seemed to have enjoyed the DTTC training. They shared many positive opinions after each session and seemed to look forward to playing DTTC once a week.
Evaluation Outcomes
Pre- and post-intervention group statistics and group × time interactions are shown in Table 1. There was a significant difference between the groups regarding the changes (intervention to baseline) in delta-TMT. There were no significant differences among the other measures.
Table 1.
Outcome measures by group at pre- and post-intervention.
| Measures | Pre-intervention, mean (SD) |
Post-intervention, mean (SD) |
Group × Time F value |
Degrees of freedom | P value | |
| VFT a |
|
|
||||
|
|
TGb | 11.96 (3.55) | 12.04 (3.26) | 0.09 | 1,38 | .76 |
|
|
CGc | 11.38 (4.21) | 11.38 (4.07) |
|
|
|
| TMT-A d |
|
|
||||
|
|
TG | 71.6 (23.8) | 68.4 (19.9) | 0.51 | 1,38 | .48 |
|
|
CG | 82.2 (27.1) | 70.0 (15.5) |
|
|
|
| TMT-B |
|
|
||||
|
|
TG | 120.3 (55.1) | 110.4 (39.2) | 2.73 | 1,38 | .11 |
|
|
CG | 131.8 (62.6) | 134.9 (61.1) |
|
|
|
| ΔTMT |
|
|
||||
|
|
TG | 48.8 (43.9) | 42.2 (29.0) | 4.94 | 1,36 | .03 |
|
|
CG | 49.5 (51.8) | 64.9 (54.7) |
|
|
|
aVFT: verbal fluency test
bTG: training group
cCG: control group
dTMT: trail-making test
Discussion
Principal Findings
The delta-TMT score was significantly improved after DTTC training. The results suggested that DTTC training was effective in improving executive cognitive functions. In our unpublished data, DTTC training was useful for improving balance ability and mobility among elderly people [10]. Thus, DTTC training has the capability of improving both physical and cognitive functions. Executive cognitive functions are closely related to DT performance and are good predictors of falling [20]. Thus, an improvement in executive functions, by DTTC training, has a positive impact on DT ability and the prevention of falling.
Conversely, the TMT-A and -B scores were not significantly improved. In the TMT-A, both groups improved similarly. On the other hand, in the TMT-B, only the TG had a tendency to improve the score, while CG showed little change. That is why the score of delta-TMT in CG increased and in TG decreased. The TMT-A and -B are used to assess visual scanning, cognitive flexibility, and executive functions [17]. The delta-TMT score is considered a more accurate measurement of executive functions [21,22]. That is, the results reflect specific improvement in executive cognitive functions. The reason is that DTTC training involves executive tasks that are the control of goal-oriented actions and adaptive behaviors. Additionally, VFT was also not significantly improved after DTTC training. It includes recalling tasks as their main elements; however, DTTC training does not involve recalling the task. This is considered the reason why the result of VFT was not significantly changed.
Previous studies reported that other “exergames,” based on Nintendo Wii Fit (Nintendo, Kyoto, Japan) or other devices, improved balance and leg muscle functions [23,24]. However, in these cases, the user needs control devices to capture motions and longer and more frequent exercise is required, compared with DTTC training, to obtain physical effects. DTTC overcomes these weaknesses and can offer comparable cognitive and physical benefits to users. Other previous studies have shown that a home-based dance device, using videogame technology, also improved the physical and cognitive parameters of fall risk in elderly people [25]. These home-based training tools are expected to increase the improvement of various functions and lead to fall prevention; our DTTC device is similar to these tools.
Limitations
There are several limitations to this study. First, the intervention effects in this study were not due solely to the DTTC training. That means the rhythmic stepping exercise involving cognitive ability in both groups also improves cognitive ability. Second, participants in both groups may have had higher motivation and interest in health issues and fall risk minimization than the general elderly population. An investigation into the effects of DTTC training on functions in frail, elderly adults is necessary, in the future.
Conclusions
In this study, the ANCOVA results of delta-TMT reveal that group × time interactions were statistically significant. They suggest that DTTC training is effective at improving executive cognitive functions in particular.
Acknowledgments
The authors thank the participants and are grateful to the department staff for helpful advice.
Abbreviations
- CG
control group
- DT
dual task
- DTTC
Dual-Task Tai Chi
- TG
training group
- TMT
trail-making test
- VFT
verbal fluency test
Footnotes
Conflicts of Interest: None declared.
References
- 1.Kueider AM, Parisi JM, Gross AL, Rebok GW. Computerized cognitive training with older adults: a systematic review. PLoS One. 2012;7(7):e40588. doi: 10.1371/journal.pone.0040588. http://dx.plos.org/10.1371/journal.pone.0040588. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Kamegaya T, Long-Term-Care Prevention Team of Maebashi City. Maki Y, Yamagami T, Yamaguchi T, Murai T, Yamaguchi H. Pleasant physical exercise program for prevention of cognitive decline in community-dwelling elderly with subjective memory complaints. Geriatr Gerontol Int. 2012 Oct;12(4):673–9. doi: 10.1111/j.1447-0594.2012.00840.x. [DOI] [PubMed] [Google Scholar]
- 3.Kramer A, Hahn S, Cohen N, Banich M, McAuley E, Harrison C, Chason J, Vakil E, Bardell L, Boileau R, Colcombe A. Ageing, Fitness and Neurocognitive Function. Nature. 1999;400:418–419. doi: 10.1038/22682. [DOI] [PubMed] [Google Scholar]
- 4.Hillman CH, Erickson KI, Kramer AF. Be smart, exercise your heart: exercise effects on brain and cognition. Nat Rev Neurosci. 2008 Jan;9(1):58–65. doi: 10.1038/nrn2298. [DOI] [PubMed] [Google Scholar]
- 5.Silsupadol P, Shumway-Cook A, Lugade V, van Donkelaar P, Chou LS, Mayr U, Woollacott MH. Effects of single-task versus dual-task training on balance performance in older adults: a double-blind, randomized controlled trial. Arch Phys Med Rehabil. 2009 Mar;90(3):381–7. doi: 10.1016/j.apmr.2008.09.559. http://europepmc.org/abstract/MED/19254600. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 6.Lundin-Olsson L, Nyberg L, Gustafson Y. Attention, frailty, and falls: the effect of a manual task on basic mobility. J Am Geriatr Soc. 1998 Jun;46(6):758–61. doi: 10.1111/j.1532-5415.1998.tb03813.x. [DOI] [PubMed] [Google Scholar]
- 7.Yamada M, Aoyama T, Arai H, Nagai K, Tanaka B, Uemura K, Mori S, Ichihashi N. Dual-task walk is a reliable predictor of falls in robust elderly adults. J Am Geriatr Soc. 2011 Jan;59(1):163–4. doi: 10.1111/j.1532-5415.2010.03206.x. http://onlinelibrary.wiley.com/doi/10.1111/j.1532-5415.2010.03206.x/abstract;jsessionid=3DA7C7EF0E1E839C591F0982F39F79D9.f03t01. [DOI] [PubMed] [Google Scholar]
- 8.Okamoto H, Kayama M, Yamada M. The development of a system for the assessment of a dual-task performance based on a motion-capture device. 9th International Conference on Disability, Virtual Reality & Associated Technologies; Sept 10 - 12, 2012; Laval, France. 2012. p. 483. [Google Scholar]
- 9.Kayama H, Okamoto K, Nishiguchi S, Nagai K, Yamada M, Aoyama T. Concept software based on Kinect for assessing dual-task ability of elderly people. Games for Health Journal. 2012 Oct;1(5):348–352. doi: 10.1089/g4h.2012.0019. [DOI] [PubMed] [Google Scholar]
- 10.Kayama H, Okamoto K, Nishiguchi S, Yukutake T, Tanigawa T, Nagai K, Yamada M, Aoyama T. Efficacy of an exercise game based on Kinect in improving physical performances of fall risk factors in community-dwelling older adults. Games for Health Journal. 2013 Aug;2(4):247–252. doi: 10.1089/g4h.2013.0006. [DOI] [PubMed] [Google Scholar]
- 11.Yamada M, Tanaka B, Nagai K, Aoyama T, Ichihashi N. Rhythmic stepping exercise under cognitive conditions improves fall risk factors in community-dwelling older adults: Preliminary results of a cluster-randomized controlled trial. Aging Ment Health. 2011 Jul 1;15(5):647–53. doi: 10.1080/13607863.2010.551341. [DOI] [PubMed] [Google Scholar]
- 12.Melzer I, Oddsson LIe. Improving balance control and self-reported lower extremity function in community-dwelling older adults: a randomized control trial. Clin Rehabil. 2013 Mar;27(3):195–206. doi: 10.1177/0269215512450295. [DOI] [PubMed] [Google Scholar]
- 13.Yamada M, Tanaka B, Nagai K, Aoyama T, Ichihashi N. Trail-walking exercise and fall risk factors in community-dwelling older adults: preliminary results of a randomized controlled trial. J Am Geriatr Soc. 2010 Oct;58(10):1946–51. doi: 10.1111/j.1532-5415.2010.03059.x. [DOI] [PubMed] [Google Scholar]
- 14.Kalbe E, Calabrese P, Schwalen S, Kessler J. The Rapid Dementia Screening Test (RDST): a new economical tool for detecting possible patients with dementia. Dement Geriatr Cogn Disord. 2003;16(4):193–9. doi: 10.1159/000072802. [DOI] [PubMed] [Google Scholar]
- 15.Buchner DM, Cress ME, de Lateur BJ, Esselman PC, Margherita AJ, Price R, Wagner EH. The effect of strength and endurance training on gait, balance, fall risk, and health services use in community-living older adults. J Gerontol A Biol Sci Med Sci. 1997 Jul;52(4):M218–24. doi: 10.1093/gerona/52a.4.m218. [DOI] [PubMed] [Google Scholar]
- 16.Gardner M, Robertson M, Campbell A. Exercise in preventing falls and fall related injuries in older people: a review of randomised controlled trials. Br J Sports Med. 2000 Feb;34(1):7–17. doi: 10.1136/bjsm.34.1.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 17.War Department Adjutant General’s Office . Army Individual Test Battery. Washington DC: War Department; 1944. Manual of directions and scoring. [Google Scholar]
- 18.Benton AL. Differential behavioral effects in frontal lobe disease. Neuropsychologia. 1968 Mar;6(1):53–60. doi: 10.1016/0028-3932(68)90038-9. [DOI] [Google Scholar]
- 19.Nemoto T, Kashima H, Mizuno M. Contribution of divergent thinking to community functioning in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):517–24. doi: 10.1016/j.pnpbp.2006.12.001. [DOI] [PubMed] [Google Scholar]
- 20.Mirelman A, Herman T, Brozgol M, Dorfman M, Sprecher E, Schweiger A, Giladi N, Hausdorff JM. Executive function and falls in older adults: new findings from a five-year prospective study link fall risk to cognition. PLoS One. 2012;7(6):e40297. doi: 10.1371/journal.pone.0040297. http://dx.plos.org/10.1371/journal.pone.0040297. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 21.Lezak MD, Howieson DB, Bigler ED, Tranel DD. Neuropsychological Assessment. New York: Oxford University Press, USA; 2004. [Google Scholar]
- 22.Corrigan JD, Hinkeldey NS. Relationships between parts A and B of the Trail Making Test. J Clin Psychol. 1987 Jul;43(4):402–9. doi: 10.1002/1097-4679(198707)43:4<402::aid-jclp2270430411>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
- 23.Jorgensen MG, Laessoe U, Hendriksen C, Nielsen OB, Aagaard P. Efficacy of Nintendo Wii training on mechanical leg muscle function and postural balance in community-dwelling older adults: a randomized controlled trial. J Gerontol A Biol Sci Med Sci. 2013 Jul;68(7):845–52. doi: 10.1093/gerona/gls222. [DOI] [PubMed] [Google Scholar]
- 24.Sullivan B, Harding AG, Dingley J, Gras LZ. Improvements in dynamic balance using an adaptive snowboard with the Nintendo Wii. Games for Health Journal. 2012 Aug;1(4):269–273. doi: 10.1089/g4h.2012.0006. [DOI] [PubMed] [Google Scholar]
- 25.Schoene D, Lord SR, Delbaere K, Severino C, Davies TA, Smith ST. A randomized controlled pilot study of home-based step training in older people using videogame technology. PLoS One. 2013;8(3):e57734. doi: 10.1371/journal.pone.0057734. http://dx.plos.org/10.1371/journal.pone.0057734. [DOI] [PMC free article] [PubMed] [Google Scholar]