Table 1.

SNPs Examined and Allele Frequency

Gene	Chromosome	SNP	Function	RS#	Allele Frequency
					Observed	Reported†
GCK	7p15.3-p15.1	−515G>A	Promoter	rs1799884	0.194	0.203
		IVS1-11823G>A	Intron	rs2908292	0.209	0.2
		IVS1+6037T>C	Intron	rs758985	0.175	0.175
		IVS1+9652C>T	Intron	rs2300586	0.165	0.158
		IVS1+11382G>A	intron	rs2244164	0.445	0.45
		IVS3-1489C>T	Intron	rs2268572	0.184	0.175
		IVS6+87A>C	intron	rs2268573	0.479	0.457
GFPT1	2p13	IVS12-1764C>T	Intron	rs4625963	0.147	0.167
		IVS14-3094T>C	Intron	rs12466648	0.173	0.186
		Ex19-115G>T	3'UTR	rs2667	0.413	0.408
		*4058A>G	3'Flank	rs13751	0.39	0.408
GPI	19q13.1	IVS6-378T>C	Intron	rs8191376	0.072	0.07
		IVS9+2363C>G	Intron	rs7248411	0.177	0.181
		Ex6+3A>G	G163G	rs1801015	0.07	0.103
HK2	2p13	IVS1-6165G>A	Intron	rs680545	0.446	0.45
		IVS1+7072C>T	Intron	rs35902493	0.352	0.38
		IVS2+3581C>T	Intron	rs3771781	0.415	0.48
		Ex1+318A>G	5'UTR	rs656489	0.474	0.45
		Ex4+51A>T	Q142H	rs2229621	0.157	0.233
		Ex7+62T>C	D251D	rs2229622	0.216	0.237
		Ex15+41C>T	N692N	rs2229626	0.398	0.408
		Ex16-78A>G	L766L	rs10194657	0.373	0.35
		Ex17-79G>A	R844K	rs2229629	0.21	0.2
		Ex18+407T>G	3'UTR	rs943	0.458	0.455
OGT	Xq13	IVS8-72G>A	Intron	rs3736670	0.151	0.142
		IVS18-424A>G	Intron	rs6525489	0.43	0.45

SNP, single nucleotide polymorphism; RS#, reference SNP identification number; UTR, untranslated region.

^†The reported minor allele frequency was from NCBI dbSNP database.