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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Synapse. 2013 Jul 27;67(12):875–881. doi: 10.1002/syn.21696

Figure 2.

Figure 2

Prior METH self-administration reduced the persistent but not acute serotonergic deficits in the cortex induced by a binge exposure to METH 1 d after the start of the last self-administration session. No protection was afforded by prior self-administration when the binge exposure occurred 15 d after the last self-administration session. Rats self-administered METH (0.12 mg/infusion) or saline (10 µl/infusion) for 7 d (8 h/d), received a binge exposure to METH 1 d after the start of the last self-administration session, and were sacrificed 7 d (Panel A and D; Panel A- Saline/Saline NE: 9.22±0.47 pg/µg protein; Saline/Saline 5HT: 8.11±0.33 pg/µg protein) or 1 h (Panel B and E; Panel B-Saline/Saline NE: 8.40±0.55 pg/µg protein; Saline/Saline 5HT: 8.73±0.79 pg/µg protein) after the last injection. Rats in Panels C and F self-administered as described above, but received the binge exposure to METH 15 d after the last self-administration session and were sacrificed 7 d later (Panel C- Saline/Saline NE: 8.29±0.66 pg/µg protein; Saline/Saline 5HT: 5.97±0.49 pg/µg protein). *p<0.05 compared to Saline/Saline; **p<0.05 compared to all other groups. Panels D, E, and F are from McFadden et al., 2012B with permission.