Table 3. Plasma concentrations of (S)-YK-4-279 at 20 minutes following IP injection of 200 mg/kg of YK-4-279 (racemic mixture) in various formulations to C57BL/6 mice.
Vehicle | % Lecithin | % DMSO | % Soybean Oil | (S)-YK-4-279 Concentrations (¼M) |
---|---|---|---|---|
10% w/v sucrose, 1% v/v Tween 80, 5% v/v ethanol, lecithin (variable), soybean oil (variable), DMSO (variable) in DI water | 0.25 | 0 | 0 | 10.5 ± 8.6 |
1.2 | 0 | 10 | 20.9 ± 22.8 | |
2.5 | 0 | 10 | 19.8 ± 20.5 | |
1.2 | 10 | 0 | 35.8 ± 45.0 | |
1.2 | 10 | 10 | 39.1 ± 54.6 | |
2.5 | 10 | 0 | 59.7 ± 58.6 | |
2.5 | 10 | 10 | 21.3 ± 11.3 |