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. 2013 Nov 11;5(2):338–350. doi: 10.18632/oncotarget.1495

Table 3. Plasma concentrations of (S)-YK-4-279 at 20 minutes following IP injection of 200 mg/kg of YK-4-279 (racemic mixture) in various formulations to C57BL/6 mice.

Five mice were used for each formulation, and mean (±SD) concentrations of (S)-YK-4-279 are shown in the table

Vehicle % Lecithin % DMSO % Soybean Oil (S)-YK-4-279 Concentrations (¼M)
10% w/v sucrose, 1% v/v Tween 80, 5% v/v ethanol, lecithin (variable), soybean oil (variable), DMSO (variable) in DI water 0.25 0 0 10.5 ± 8.6
1.2 0 10 20.9 ± 22.8
2.5 0 10 19.8 ± 20.5
1.2 10 0 35.8 ± 45.0
1.2 10 10 39.1 ± 54.6
2.5 10 0 59.7 ± 58.6
2.5 10 10 21.3 ± 11.3