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. 1996 Apr 16;93(8):3536–3541. doi: 10.1073/pnas.93.8.3536

cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes.

J Bodor 1, A L Spetz 1, J L Strominger 1, J F Habener 1
PMCID: PMC39645  PMID: 8622971

Abstract

Stimulation of the cAMP-dependent signaling pathway exerts an inhibitory effect on the proliferation and effector functions of T cells. The ability of T cells to form high intracellular levels of cAMP is acquired during development in the human thymus and is retained by the majority of mature peripheral T lymphocytes. Here we show that elevated cAMP levels in T cells correlate with the expression of the potent transcriptional repressor ICER (inducible cAMP early repressor) previously described in the hypothalamic-pituitary-gonadal axis. Further, in transcriptional assays in vivo, ICER inhibits calcineurin-mediated expression of the interleukin 2 promoter as well as Tax-mediated transactivation of the human T-lymphotropic virus type I (HTLV-I) promoter. Thus, the induction of ICER in T cells may play an important role in the cAMP-induced quiescence and the persistent latency of HTLV-I.

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Selected References

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