Table 2.

Incidence of Hepatobiliary Cancers in Individuals With Acquired Immunodeficiency Syndrome (AIDS), 1980–2009^a

Cancer Histology Typeb	Observed Cases	Incidence Rate per 100,000 Person-Years	SIR [95% CI]
Hepatocellular carcinoma	366	16.9	3.8 [3.5–4.3]
Cholangiocarcinoma (cancer of the intrahepatic and extrahepatic bile duct)	22	1.02	1.4 [0.9–2.1]
Other liver and intrahepatic bile duct cancers (except cholangiocarcinoma)	27	1.25	3.3 [2.2–4.7]
Other extrahepatic bile duct cancers (except cholangiocarcinoma)	0	0.00	0.0 [0–4.5]
Gallbladder cancer	11	0.51	1.4 [0.7–2.5]

Abbreviations: CI, confidence interval; SIR, standardized incidence ratio.

^aThis analysis included patients who were diagnosed 4 to 120 months after their AIDS diagnosis.

^bHepatobiliary cancers were classified according to the International Classification of Diseases for Oncology (ICD-O3; 3rd edition) topography and morphology codes described elsewhere (for a detailed listing of the cancers included in these categories, please refer to the article by Altekruse SF, Devesa SS, Dickie LA, McGlynn KA, Kleiner DE. Histological classification of liver and intrahepatic bile duct cancers in SEER registries. J Registry Manag. 2011;38:201–205.¹⁴).