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. 2012 Nov;8(11):776–778.

Gastrointestinal Bezoars: History and Current Treatment Paradigms

Katharine Eng 1,, Marsha Kay 1
PMCID: PMC3966178  PMID: 24672418

Gastrointestinal (GI) bezoars are aggregates of inedible or undigested material found in the GI tract. For many centuries, bezoars have been found in the digestive tracts of both humans and animals, and although bezoars are most commonly found in the stomach, they can be found anywhere in the GI tract.1 The term “bezoar” is thought to be derived from the Arabic word “badzehr” or the Persian word “panzehr,” both of which mean “counterpoison” or “antidote.” In ancient times, bezoars from animals were thought to have medicinal and magical properties, and they were considered antidotes to a variety of poisons and diseases. Bezoars were introduced to Europe from the Middle East during the 11th century, and they were popular as medicinal remedies; however, their use started to fall out of favor by the 18th century.2 In the 1500s, the famous surgeon Ambroise Paré tested the healing properties of a bezoar stone. A cook in the king’s court had been caught stealing fine silver and was sentenced to death by hanging. As an alternative, the cook was granted the opportunity to receive a poison followed by a bezoar as a potential antidote under the supervision of Paré. It was agreed that if the cook survived the poison, his life would be spared. The cook lived for only 7 hours; thus, Paré concluded that the bezoar stone could not cure all poisons.3 Currently, the term “bezoar” is not used to refer to an unsuccessful antidote but rather to a potentially serious medical problem that requires timely diagnosis and appropriate therapy.

The formation of bezoars can occur in individuals with normal GI physiology and anatomy. However, patients with altered GI anatomy and/or motility are at an increased risk for the development of bezoars. Risk factors for bezoar formation include a partial gastrectomy with or without a vagotomy, diabetes mellitus complicated by gastroparesis, or other systemic illnesses that may affect GI motility.4,5 Other predisposing factors include poor mastication, excessive intake of fiber, cystic fibrosis, or psychiatric illness.1,6,7

For successful management of bezoars, it is important to distinguish among their various types. Bezoars are typically grouped into 1 of 4 types according to their composition: phytobezoars (which are composed of indigestible food particles that are found in vegetable or fruit fibers), trichobezoars (which are composed of a conglomeration of hair and food particles), lactobezoars (which are composed of milk protein), or pharmacobezoars (which are concretions of various medications).6 Phytobezoars are the most common type of bezoars, accounting for approximately 40% of all reported bezoars. Diospyrobezoars, a subset of phytobezoars, are composed of persimmons and can be particularly hard in consistency, as they are formed by the agglutination of tannins in fruit skins.1

The initial presentation of a bezoar often depends on its composition. Lactobezoars may present in premature infants or newborns with symptoms of feeding intolerance, abdominal distension, irritability, and/or vomiting. A physical examination may reveal a palpable abdominal mass in these patients.8 Pharmacobezoars can present with symptoms of gastric outlet obstruction, but these bezoars can also produce symptoms due to their pharmacologic properties. As a result, there is an increased potential for drug intoxication in these patients.9 Trichobezoars can take time to form—sometimes up to several years—and these bezoars may first present with subtle symptoms such as nausea or early satiety. However, as trichobezoars grow in size, they may present with epigastric pain, gastric outlet obstruction, ulceration, GI bleeding, and/or, potentially, perforation.6,10 Phytobezoars usually form more rapidly than trichobezoars. Phytobezoars can present with nausea, vomiting, and/or symptoms of gastric outlet obstruction. These symptoms are similar to those reported in the 3 patients described by Kramer and Pochapin.11 Complications from phytobezoars can include ulceration, bleeding, bowel obstruction, and/or perforation. Therefore, appropriate and prompt diagnosis is important in the care of patients with bezoars in order to prevent the development of potentially severe complications.

The diagnosis of a bezoar involves obtaining a thorough patient history, which includes screening patients for risk factors and questioning patients regarding their diet and medications. A physical examination may occasionally reveal a palpable abdominal mass. Halitosis may signify the presence of putrefying material in the stomach, and clinicians may observe patches of alopecia in patients with trichobezoars similar to those seen in individuals with trichotillomania (an impulse control disorder involving a compulsive urge to pull out one’s hair).

In terms of imaging, plain abdominal radiographs are often the initial modality for diagnosing bezoars. In 1 study, an abdominal radiograph raised suspicion for a bezoar in 56% of cases.12 Barium studies are also useful for identifying bezoars and estimating their size. However, barium studies can interfere with diagnostic and therapeutic endoscopic procedures by impeding visualization; this consequence should be carefully considered before the administration of oral contrast. Both ultrasound and computed tomography (CT) scans have been found to be reliable methods for diagnosing GI bezoars, although CT scans are more accurate and can more readily identify the presence of any additional GI bezoars that may be present.13 However, endoscopy remains the diagnostic method of choice for gastric bezoars because it enables visualization and tissue sampling of the bezoar; in addition, endoscopy can occasionally have therapeutic applications.14 Kramer and Pochapin used endoscopy to diagnose a phytobezoar in each of their patients.11

The goals of bezoar treatment are the removal of the bezoar and the prevention of bezoar recurrence. Knowing the type and location of the bezoar are important for determining appropriate management. Management strategies for gastric phytobezoars can be divided into 3 categories: lavage or dissolution, fragmentation, and/or retrieval. There are several methods for dissolving and/or retrieving bezoars, and these methods may be used in conjunction, depending on the type and location of the bezoar.1 As discussed by Kramer and Pochapin, phytobezoars were often treated surgically prior to the 1960s.11 Since then, a wider range of therapeutic options have been used, including acetylcysteine, papain, metoclopramide, cellulase, and instillation of Coca-Cola (The Coca-Cola Company), the latter of which was first reported in 2002.15-19 However, some of these agents are associated with adverse reactions; for example, case reports have found gastric ulceration, esophageal perforation, and hypernatremia with the use of papain, which is a proteolytic enzyme.20 Both cellulase and Coca-Cola have been better tolerated, without any adverse effects reported to date.19-24 A recent paper reviewing the medical management of bezoars reported on the administration of 3–5 g of cellulase enzyme that was dissolved in 300–500 mL of water and administered orally each day for 2–5 days.6 Coca-Cola administration has been performed by nasogastric lavage (NG) of 3 L of Coca-Cola over 12 hours, oral ingestion, as well as endoscopic injection and irrigation.19,23-25

Kramer and Pochapin reported the concomitant use of Diet Coke (The Coca-Cola Company) and cellulase ingestion for the dissolution of gastric phytobezoars in 3 patients.11 The patients were instructed to drink one 12-oz can of Diet Coke twice daily and to take 1 cellulase tablet twice daily until resolution of the bezoar could be endoscopically confirmed, a process that took 6–8 weeks.11 Tis case series is the first to report the combined use of cellulase and Diet Coke ingestion for dissolution of phytobezoars. Prior studies have examined the use of either cellulase or Coca-Cola over a shorter period of time. In particular, Coca-Cola has often been administered via NG lavage over 12 hours, a process that requires hospitalization. The treatment approach reported by Kramer and Pochapin is interesting, as it has the potential to eliminate the need for inpatient hospitalization and NG tube placement, thus increasing patient comfort.11 It is unclear how many endoscopic sessions are needed with this treatment approach; if the number of sessions is minimal, this approach may also be a less expensive option for treatment of gastric phytobezoars, as it avoids the cost of hospitalization. Another novel aspect of this case series is that it is one of the first studies to show longer-term use of cellulase without any adverse effects; most studies have reported the use of this agent for only 2–5 days.

In addition to the dissolution therapy described above, there are a variety of methods that can be used for the fragmentation and retrieval of bezoars. Endoscopic therapy has focused on mechanical disruption via a variety of instruments, including polypectomy snares, tripod forceps, water piks, neodymium yttrium aluminum garnet lasers, and bezotriptors (modified lithotripters that break up bezoars with shock waves).26,27 A new endoscopic technique involves the removal of gastric phytobezoars via suction through a large-channel endoscope. In a case series, this technique was found to be a safe, effective, and rapid method of removing large gastric phytobezoars.28 Although endoscopic therapy may be the procedure of choice in terms of fragmentation and retrieval, surgical removal should be considered in patients who fail medical therapy or who have complications such as significant bleeding, obstruction, and/or perforation.

Other types of bezoars require different management strategies, which will be briefly outlined here. Unlike phytobezoars, trichobezoars are often resistant to enzymatic dissolution; therefore, most trichobezoars are surgically removed, although endoscopic removal has been successful in some cases.6 On the other hand, lactobezoars are typically managed conservatively, with the most common treatment approach involving the patient being nil per mouth and receiving intravenous fluids alone or in combination with gastric lavage; however, endoscopy and surgery are occasionally needed.8 The treatment of pharmacobezoars depends on the pharmaceutical agent and the patient’s clinical status; treatment options can be quite varied and can range from gastric decontamination to dissolution therapy, bowel irrigation, or more aggressive interventions such as endoscopic or surgical removal.9

Summary

As GI bezoars are a potentially serious problem, it is important to be aware of their risk factors, as well as subtle clinical findings that may facilitate early investigation and diagnosis. Knowing the location and type of the bezoar are important, as this information influences patient management. Treatment of gastric phytobezoars has included lavage and dissolution therapy with a variety of dissolution products—including a novel and noninvasive combination technique reported by Kramer and Pochapin—as well as endoscopic fragmentation and retrieval, and surgery.11 Following removal of a bezoar, it is prudent to prevent future occurrences via dietary counseling, avoidance of certain medications, and correction of underlying motility problems if present.

Footnotes

The authors have no conflicts of interest to report.

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