Table 4.
Gene-diet interaction effects on the plasma TG response.
| Gene | tSNP | Genotype | β (Interaction Term) 1 | P Genotype 2 | P Dietary Fat Intake 2 | P Interaction Effect 2 |
|---|---|---|---|---|---|---|
| Total fat intakes (%) | ||||||
| RXRA | rs11185660 | C/C | 3.70 ± 1.16 | 0.004 | 0.0009 | 0.004 |
| C/T | 1.02 ± 0.61 | |||||
| T/T | 0 | |||||
| Saturated fat intakes (%) | ||||||
| RXRA | rs10881576 | T/T | 8.52 ± 2.61 | 0.007 | 0.0004 | 0.004 |
| C/T | 1.84 ± 1.21 | |||||
| C/C | 0 | |||||
| rs12339187 | A/G + G/G | 3.20 ± 1.25 | 0.02 | 0.005 | 0.01 | |
| A/A | 0 | |||||
| rs11185660 | C/C | 9.39 ± 2.66 | 0.003 | <0.0001 | 0.002 | |
| C/T | 1.69 ± 1.23 | |||||
| T/T | 0 | |||||
| Polyunsaturated fat intakes (%) | ||||||
| ACOX1 | rs17583163 | C/C + C/T | 6.79 ± 2.34 | 0.02 | 0.09 | 0.004 |
| T/T | 0 | |||||
1 Homozygotes for the major allele is the reference group; 2 p-values were determined with an ANOVA using dietary fat intakes as continuous values adjusted for age, sex and BMI.