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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1985 Jan;82(2):479–482. doi: 10.1073/pnas.82.2.479

Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line.

M Wabl, P D Burrows, A von Gabain, C Steinberg
PMCID: PMC397062  PMID: 3918310

Abstract

Most cells in the well-known pre-B-lymphocyte line 18-81 have correctly assembled genes for both alleles at the immunoglobulin heavy chain locus. Only one allele is "active"; the other, "silent" allele contains an amber termination codon. The rate of reversion of this amber codon was determined to be 0.3-1 X 10(-4) per cell generation. This high rate is termed hypermutation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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